flutamide 7.5mg Control (2) (p<0.005) 2 Kdm5a Sertoli Leydig Kdm5a lysine (K)-specific demethylase 5A 3 18 RT-PCR Kdm5a 3 Western Blotting

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(3) H3K4 3 18 (4) GC-1 Kdm5a 1 RT-PCR (1) S-D 14-20

2 (3) H3K (4) GC-1 Kdm5a 1 RT-PCR (1) S-D flutamide 7.5mg 9 UDT Control (2) Kdm5alysine (K)-specific demethylase 5A3 18 Kdm5a RT-PCR Western Blotting 1GC-1 Kdm5a (1) 9 24 (2) 24 Kdm5a (p<0.005) 2Kdm5a Sertoli Leydig 3

3 5Kdm5a 2Kdm5a 3Kdm5a (3) 9 H3K4me2/me3 4 9 Kdm5a Kdm5a H3K4 H3K4 Kdm5a 4H3K4 (4) Kdm5a GC-1 Esr2Neurog3Pou5f1RetThy1 (p<0.005) Nishio H, Hayashi Y, Moritoki Y, Kamisawa H, Mizuno K, Kojima Y, Kohri K. Distinctive changes in histone H3K4 modification mediated via Kdm5a expression in spermatogonial stem cells of cryptorchid testes. J Urol. 191: , 2014 (doi: /j.juro ),

4 2. Hayashi Y, Mizuno K, Kurokawa S, Nakane A, Kamisawa H, Nishio H, Moritoki Y, Tozawa K, Kohri K, Kojima Y. Extravesical robot-assisted laparoscopic ureteral reimplantation for vesicoureteral reflux: Initial experience in Japan with the ureteral advancement technique. Int J Urol. 10: , 2014 (doi: /iju.12483), 3. Mizuno K, Kojima Y, Kamisawa H, Moritoki Y, Nishio H, Nakane A, Kurokawa S, Kohri K, Hayashi Y. Elucidation of distinctive genomic DNA structures in patients with 46,XX testicular disorders of sex development using genome-wide analyses. J Urol. 192: , 2014 (doi: /j.juro ), 4. Moritoki Y, Hayashi Y, Mizuno K, Kamisawa H, Nishio H, kurokawa S, Ugawa S, Kojima Y, Kohri K. Expression profiling of microrna in cryptorchid testes: mir-135a contributes to the maintenance of spermatogonial stem cells by regulating FoxO1. J Urol. 191: , 2014 (doi: /j.juro ), 5. Mizuno K, Kojima Y, Kamisawa H, Moritoki Y, Nishio H, Kohri K, Hayashi Y. Gene expression profile during testicular development in patients with SRY-negative 46,XX testicular disorder of sex development. Urology. 82: 1453.e1-7, 2013 (doi: /j.urology ), 6. Hayashi Y, Mizuno K, Moritoki Y, Nakane A, Kato T, Kurokawa S, Kamisawa H, Nishio H, Kohri K, Kojima Y. Can spongioplasty prevent fistula formation and correct penile curvature in TIP urethroplasty for hypospadias? Urology. 81: , 2013 (doi: /j.urology ), 7. Mizuno K, Hayashi Y, Kamisawa H, Nishio H, Moritoki Y, Kohri K. Expression analysis of the pluripotency marker UTF-1 for determining the applicability of testis-sparing surgery for prepubertal testis tumors. J Pediatr Surg. 1: , 2013, e/pii/s Nishio H, Mizuno K, Moritoki Y, Kamisawa H, Kojima Y, Mizuno H, Kohri K, Hayashi Y. Clinical features and testicular morphology in patients with Kallmann syndrome. Urology. 79: 684-6, 2012 (doi: /j.urology ), 9. Mizuno K, Kojima Y, Nishio H, Tozawa K, Mizuno H, Kohri K, Hayashi Y. Transumbilical laparoendoscopic single-site gonadectomy for Turner's syndrome with Y-chromosome mosaicism. J Pediatr Urol. 8: e39-42, 2012 (doi: /j.jpurol ), 10. Mizuno K, Kojima Y, Kamisawa H, Kurokawa S, Moritoki Y, Nishio H, Hayashi Y, Kohri K. Feasible etiology of vanishing testis regarding disturbance of testicular development: histopathological and

5 immunohistochemical evaluation of testicular nubbins. Int J Urol. 19: 450-6, 2012 (doi: /j x), 11. Hamamoto S, Tozawa K, Nishio H, Kawai N, Kohri K. Successful treatment of primary malignant lymphoma of the penis by organ-preserving rituximab-containing chemotherapy. Int J Clin Oncol. 17: 181-4, 2012 (doi: /s ), KDM5A. 103 ANA, ,, Kdm5a. 33,, Nishio H, Hayashi Y, Moritoki Y, Kamisawa H, Kurokawa S, Nakane A, Mizuno K, Maruyama T, Kojima Y, Kohri K. Distinctive changes in histone H3K4 modification mediated via Kdm5a expression in spermatogonial stem cells of cryptorchid testes. 109 th Annual Meeting of the American Urological Association, Orlando(USA), Nishio H, Hayashi Y, Moritoki Y, Kamisawa H, Kurokawa S, Nakane A, Mizuno K, Maruyama T, Kojima Y, Kohri K. Testosterone treatment prior to hypospadias surgery transiently upregulates VEGFA mediated via AR and causes histological changes in foreskin. 62 nd Annual Meeting of the Society for Pediatric Urology, Orlando(USA), H3K4 Kdm5a. 102,, Nishio H, Mizuno K, Kurokawa S, Kamisawa H, Imura M, Moritoki Y, Shibata Y, Nakane A, Kato T, Maruyama T, Kojima Y, Hayashi Y, Kohri K. Clinical features and testicular morphology in infantile patients with Kallmann syndrome. 108 th Annual Meeting of the American Urological Association, San Diego(USA), Nishio H, Mizuno K, Kurokawa S, Kamisawa H, Imura M, Moritoki Y, Shibata

6 Y, Nakane A, Kato T, Maruyama T, Kojima Y, Hayashi Y, Kohri K. Jarid1a regulates early stage spermatogenesis by demethylating histone H3 lysine st Annual Meeting of the Society for Pediatric Urology, San Diego(USA), HAYASHI Yutaro KOJIMA Yoshiyuki MIZUNO Kentaro KUROKAWA Satoshi KAMISAWA Hideyuki MORITOKI Yoshinobu 9. Nishio H, Kojima Y, Moritoki Y, Imura M, Kamisawa H, Okada A, Mizno K, Umemoto Y, Tozawa K, Hayashi Y, Kohri K. The role of Jarid1a in spermatogenesis: Evaluation of transcriptional regulation by histone H3K4 methylation. 107 th Annual Meeting of the American Urological Association, Atlanta(USA), Nishio H, Mizuno K, Moritoki Y, Imura M, Kamisawa H, Okada A, Umemoto Y, Kojima Y, Tozawa K, Hayashi Y, Kohri K. The histological reaction of foreskin after testosterone treatment prior to hypospadias surgery. 107 th Annual Meeting of the American Urological Association, Atlanta(USA), (1) NISHIO Hidenori (2) (3) (4) KOHRI Kenjiro

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