Hjertemedicinsk Afdeling B

Transkript

1 Hjertemedicinsk Afdeling B Forskningsenhed Kardiologi Forskningsleder Forskningslektor, dr. med. Hans Mickley Forskningsområder Hjertesvigt Kardiovaskulær farmakologi Elektrofysiologi og radiofrekvensablation Evaluering af synkope og behandling af neurokardiogen synkope Pacemaker- og ICD behandling (Dansk Pacemaker og ICD register) Præventiv kardiologi (specielt dyslipidæmi, hypertension, koronar kalk-score) Præhospital behandling, herunder akut koronart syndrom (diagnose og behandling) Endoteldysfunktion (intravaskulær ultralydsundersøgelse og revaskularisationsprocedure) Kronisk iskæmisk hjertesygdom (myokardie-og karvægs biomarkører, koronar kalk-score, hjerte-ct) Etablering af biobank under OPEN (patienter med mistænkt akut koronart syndrom; raske midaldrende) Humane ressourcer Antal professorer: 0 Antal forskningslektorer/adjunkter/post.doc.: 6 Antal ph.d.-studerende: 4

2 Antal publikationer i tidsskrifter med peer review: 32 Ph.d.-afhandlinger og igangværende ph.d.-projekter Afsluttede Jordi Sanchez Dahl: Reverse remodeling after aortic valve replacement in severe valvular aortic stenosis: Effect of blockade of the angiotensin-ii receptor Igangværende Rasmus Egede. ProjektCoronary Artery Remodelling in Diabetic and Non-Diabetic Patients Asswssed : Influence of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Plaque Composition Assessed by Virtual Histology in Patients with ST- Segment Elevation Acute Myocardial Infarction (VIRHISTAMI Lotte Saaby. Projekt: Konsekvenserne af den internationale 2007 Definition af AMI undersøgt prospektivt i en dansk, konsekutiv sygehuspopulation. Projekt DEF-AMI Susanne Hosbond. Projekt: Vesselwall biomarkers in ischemic heart disease Doktor Disputats Afsluttet Lisette Okkels Jensen: Coronary artery remodelling in diabetic and non-diabetic patients assessed by intravascular ultrasound Publikationer Aagaard, Jan ; Nissen, Henrik ; Geha, Alexander S. / Midterm evaluation of hemodynamics of the Top Hat supraannular aortic valve. I: Asian Cardiovascular & Thoracic Annals ; Vol. 18, Nr. 1, s Dahl, Jordi S ; Videbaek, Lars ; Poulsen, Mikael K ; Pellikka, Patricia A ; Veien, Karsten ; Andersen, Lars Ib ; Haghfelt, Torben ; Møller, Jacob Eifer. / Effect of candesartan treatment on left ventricular remodeling after aortic valve replacement for aortic stenosis. I: American Journal of Cardiology ; Vol. 106, Nr. 5, s Diederichsen, Axel C P ; Møller, Jacob E ; Thayssen, Per ; Videbæk, Lars ; Sækmose, Susanne G ; Barington, Torben ; Kassem, Moustapha. / Changes in left ventricular filling patterns after repeated injection of autologous bone marrow cells in heart failure patients. I: Scandinavian Cardiovascular Journal ; Vol. 44, Nr. 3, s Diederichsen, Axel ; Mickley, Hans. / Coronary artery calcium score and cardiovascular event prediction. I: J A M A: The Journal of the American Medical Association ; Vol. 304, Nr. 7, s. 741; author reply 742

3 Diederichsen, Axel ; Mickley, Hans. / Screening for kalk hos asymptomatiske personer. I: Ugeskrift for Laeger ; Vol. 172, Nr. 15, s Diederichsen, Axel D; Moeller, Jesper E; Thayssen, Per; Videbaek, Lars; Saekmose, SG; Barington, T; Kassem, Moustafa. / Changes in left ventricular filling patterns after repeated injection of autologous bone marrow cells in heart failure patients. I: Scandinavian Cardiovascular Journal ; Vol. 44, Nr. 3. s Hallén, J; Jensen, Jesper K; Fagerland, MW; Jaffe, AS; Atar, Dan. / Cardiac troponin I for the prediction of functional recovery and left ventricular remodelling following primary percutaneous coronary intervention for ST-elevation myocardial infarction. I: Heart ; Vol. 96, Nr. 23. s Hassager, Christian ; Haastrup, Benedikte ; Thomsen, Kristian Korsgaard ; Hansen, Henrik Steen. / Pakkeforløb for livstruende hjertesygdomme. I: Ugeskrift for Laeger ; Vol. 172, Nr. 12, s. 939 Holme, Ingar; Fayyad, Rahid; Faergemann, Ole; Kastelein, John J; Olsson, Anders G; Tikkanen, Matti J; Larsen, Mogens Lytken; Lindahl, Christina; Holdaas, H; Pedersen, Terje R. / Cardiovascular outcomes and their relationships to lipoprotein components in patients with and without chronic kidney disease: Results from the IDEAL trial. I: Journal of Internal Medicine ; Vol. 267, Nr. 6. s Huisman, Jennifer ; Egede, Rasmus ; Rdzanek, Adam ; Böse, Dirk ; Erbel, Raimund ; Kochman, Janusz ; Jensen, Lisette Okkels ; van de Palen, Job ; Hartmann, Marc ; Mintz, Gary S ; von Birgelen, Clemens. / Between-centre reproducibility of volumetric intravascular ultrasound radiofrequency-based analyses in mild-to-moderate coronary atherosclerosis : an international multicentre study. I: EuroIntervention ; Vol. 5, Nr. 8, s Hvelplund, Anders ; Galatius, Søren ; Madsen, Mette ; Rasmussen, Jeppe N ; Rasmussen, Søren ; Madsen, Jan Kyst ; Sand, Niels P R ; Tilsted, Hans-Henrik ; Thayssen, Per ; Sindby, Eske ; Højbjerg, Søren ; Abildstrøm, Steen. / Women with acute coronary syndrome are less invasively examined and subsequently less treated than men. I: European Heart Journal ; Vol. 31, Nr. 6, s Jensen, Lisette Okkels ; Kaltoft, Anne ; Thayssen, Per ; Tilsted, Hans Henrik ; Christiansen, Evald Hoej ; Mikkelsen, Kirsten Vilain ; Maeng, Michael ; Hansen, Knud Noerregaard ; Villadsen, Anton Boel ; Madsen, Morten ; Lassen, Jens Flensted ; Pedersen, Knud Erik ; Thuesen, Leif. / Outcome in high risk patients with unprotected left main coronary artery stenosis treated with percutaneous coronary intervention. I: Catheterization and Cardiovascular Interventions ; Vol. 75, Nr. 1, s Jensen, Lisette Okkels ; Maeng, Michael ; Thayssen, Per ; Kaltoft, Anne ; Tilsted, Hans Henrik ; Lassen, Jens Flensted ; Hansen, Knud Noerregaard ; Bottcher, Morten ; Rasmussen, Klaus ; Madsen, Morten ; Johnsen, Søren Paaske ; Sørensen, Henrik Toft ; Thuesen, Leif. / Long-term outcomes after percutaneous coronary intervention in patients with and without diabetes mellitus in Western Denmark. I: American Journal of Cardiology ; Vol. 105, Nr. 11, s Jensen, Lisette Okkels ; Thayssen, Per ; Tilsted, Hans Henrik ; Ravkilde, Jan ; Junker, Anders ; Hansen, Henrik Steen ; Hansen, Knud Nørregaard ; Pedersen, Knud Erik ; Sørensen, Henrik Toft ; Thuesen, Leif ; Lassen, Jens Flensted. / Rationale and Design of a Randomized Clinical Comparison of Everolimus-Eluting (Xience V/Promus) and Sirolimus-Eluting (Cypher Select+) Coronary Stents in Unselected Patients with Coronary Heart Disease. I: Cardiology ; Vol. 116, Nr. 2, s

4 Jensen, Lisette Okkels ; Tilsted, Hans Henrik ; Thayssen, Per ; Kaltoft, Anne ; Maeng, Michael ; Lassen, Jens Flensted ; Hansen, Knud Noerregaard ; Madsen, Morten ; Ravkilde, Jan ; Johnsen, Søren Paaske ; Sørensen, Henrik Toft ; Thuesen, Leif. / Paclitaxel and sirolimus eluting stents versus bare metal stents: long-term risk of stent thrombosis and other outcomes. From the Western Denmark Heart Registry. I: EuroIntervention ; Vol. 5, Nr. 8, s Jensen, Jesper Khédri ; Ueland, T ; Gullestad, L ; Atar, D ; Mickley, H ; Aukrust, P ; Januzzi, J L. / Osteoprotegerin concentrations and prognosis in acute ischaemic stroke. I: Journal of Internal Medicine ; Vol. 267, Nr. 4, s Johansen, Marie E; Mattsson, Nick; Larsen, Mogens L. / Ekstrem hyperlipidæmi ved akut pankreatitis. I: Ugeskrift for Laeger vol. 172, Nr. 40. s Juhl, Claus B ; Højlund, Kurt ; Elsborg, Rasmus ; Poulsen, Mikael Kjaer ; Selmar, Peter E ; Holst, Jens Juul ; Christiansen, Claus ; Beck-Nielsen, Henning. / Automated detection of hypoglycemia-induced EEG changes recorded by subcutaneous electrodes in subjects with type 1 diabetes--the brain as a biosensor. I: Diabetes Research and Clinical Practice ; Vol. 88, Nr. 1, s Kofoed, Klaus F ; Madsen, Jan Kyst ; Grande, Peer ; Saunamäki, Kari ; Nielsen, Torsten Toftegård ; Kassis, Eli ; Thayssen, Per ; Rasmussen, Klaus. / Long-term effects of invasive treatment in patients with a post-thrombolytic Q-wave myocardial infarction. I: Scandinavian Cardiovascular Journal ; Vol. 44, Nr. 3, s Le V, Gill, Sabine. / Serious complications after infective endocarditis. I: Danish Medical Bulletin (Online) ; Vol. 57, Nr. 10, s. A4192 Maeng, M ; Kaltoft, A ; Tilsted, HH ; Ravkilde, J ; Jensen, Lisette Okkels ; Thayssen, Per ; Holm, N ; Christiansen, EH ; Krusell, LR ; Therkelsen, CJ ; Kristensen, SD ; Bøtker, HE ; Lassen, JF ; Thuesen, L. / Review of registry and randomised comparisons of Zotarolimuseluting and Sirolimus-eluting coronary stents in Western Denmark. I: European Journal of Cardiovascular Medicine ; Vol. 1, Nr. 2, s Nielsen, Lene H; Markenvard, John; Jensen, Jesper M; Mickley, Hans; Ovrehus, Kristian A; Noergaard, Bjarne L. / Frontline diagnostic evaluation of patients suspected of angina by coronary computed tomography reduces downstream ressource utilization when compared to conventional iscjemia testing I: International Journal of Cardiovascular Imaging. (Epub ahead Nov 2) Niemelä, Matti ; Kervinen, Kari ; Erglis, Andrejs ; Holm, Niels Ramsing ; Maeng, Michael ; Christiansen, Evald Høj ; Kumsars, Indulis ; Jegere, Sanda ; Dombrovskis, Andis ; Gunnes, Pål ; Stavnes, Sindre ; Steigen, Terje K ; Trovik, Thor ; Eskola, Markku ; Vikman, Saila ; Romppanen, Hannu ; Mäkikallio, Timo ; Hansen, Knud N ; Thayssen, Per ; Aberge, Lars ; Jensen, Lisette O ; Hervold, Anders ; Airaksinen, Juhani ; Pietilä, Mikko ; Frobert, Ole ; Kellerth, Thomas ; Ravkilde, Jan ; Aar Emptyset E, Jens ; Jensen, Jan S ; Helqvist, Steffen ; Sjögren, Iwar ; James, Stefan ; Miettinen, Heikki ; Lassen, Jens Flensted ; Thuesen, Leif ; for the Nordic-Baltic PCI Study Group. / Randomized Comparison of Final Kissing Balloon Dilatation Versus No Final Kissing Balloon Dilatation in Patients With Coronary Bifurcation Lesions Treated With Main Vessel Stenting: The Nordic-Baltic Bifurcation Study III. I: Circulation (Baltimore) ; Vol. 123, s (online) Nybo, Mads ; Hansen, Henrik Steen ; Siersted, Hans Christian ; Rasmussen, Finn. / No relationship between lung function and high-sensitive C-reactive protein in adolescence. I: Clinical Respiratory Journal ; Vol. 4, s

5 Ovrehus, Kristian A ; Jensen, Jesper K ; Mickley, Hans ; Munkholm, Henrik ; Bøttcher, Morten ; Bøtker, Hans E ; Nørgaard, Bjarne L. / Comparison of usefulness of exercise testing versus coronary computed tomographic angiography for evaluation of patients suspected of having coronary artery disease. I: American Journal of Cardiology ; Vol. 105, Nr. 6, s Pedersen, TR ; Cater, Nilo B ; Faergeman, Ole ; Kastelein, John J P ; Olsson, Anders G ; Tikkanen, Matti J ; Holme, Ingar ; Larsen, Mogens Lytken ; Lindahl, Christina ; Szarek, Michael. / Comparison of atorvastatin 80 mg/day versus simvastatin 20 to 40 mg/day on frequency of cardiovascular events late (five years) after acute myocardial infarction (from the Incremental Decrease in End Points through Aggressive Lipid Lowering [IDEAL] trial). I: American Journal of Cardiology ; Vol. 106, Nr. 3, s Poulsen, Mikael Kjaer ; Henriksen, Jan Erik ; Dahl, Jordi ; Johansen, Allan ; Gerke, Oke ; Vach, Werner ; Haghfelt, Torben ; Høilund-Carlsen, Poul Fl. ; Beck-Nielsen, Henning ; Møller, Jacob Eifer. / Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus: Prevalence and Association with Myocardial and Vascular Disease. I: Circulation. Cardiovascular Imaging ; Vol. 3, s Poulsen, Mikael Kjær ; Henriksen, Jan Erik ; Vach, W ; Dahl, J ; Møller, Jacob Eifer ; Johansen, A ; Gerke, O ; Haghfelt, T ; Høilund-Carlsen, P F ; Beck-Nielsen, H. / Identification of asymptomatic type 2 diabetes mellitus patients with a low, intermediate and high risk of ischaemic heart disease: is there an algorithm?. I: Diabetologia ; Vol. 53, Nr. 4, s Rasmussen, Klaus ; Maeng, Michael ; Kaltoft, Anne ; Thayssen, Per ; Kelbaek, Henning ; Tilsted, Hans Henrik ; Abildgaard, Ulrik ; Christiansen, Evald Høj ; Engstrøm, Thomas ; Krusell, Lars Romer ; Ravkilde, Jan ; Hansen, Peter Riis ; Hansen, Knud Nørregaard ; Abildstrøm, Steen Zabell ; Aarøe, Jens ; Jensen, Jan Skov ; Kristensen, Steen Dalby ; Bøtker, Hans Erik ; Madsen, Morten ; Johnsen, Søren Paaske ; Jensen, Lisette Okkels ; Sørensen, Henrik Toft ; Thuesen, Leif ; Lassen, Jens Flensted. / Efficacy and safety of zotarolimus-eluting and sirolimus-eluting coronary stents in routine clinical care (SORT OUT III): a randomised controlled superiority trial. I: Lancet ; Vol. 375, Nr. 9720, s Terkelsen, Christian Juhl ; Sørensen, Jacob Thorsted ; Maeng, Michael ; Jensen, Lisette Okkels ; Hansen, Hans-Henrik Tilsted ; Trautner, Sven ; Vach, Werner ; Johnsen, Søren Paaske ; Thuesen, Leif ; Lassen, Jens Flensted. / System delay and mortality among patients with STEMI treated with primary percutaneous coronary intervention. I: J A M A: The Journal of the American Medical Association ; Vol. 304, Nr. 7, s Veien, Karsten Tange ; Jensen, Jesper Khédri ; Hildebrandt, Per ; Gøtze, Jens Peter ; Nielsen, Olav Wendelboe ; Køber, Lars Valeur. / Natriuretiske peptider som hjertemarkører i klinisk praksis. I: Ugeskrift for Laeger ; Vol. 172, Nr. 30, s Würtz, Morten ; Grove, Erik ; Wulff, Lise Nielsen ; Kaltoft, Anne ; Hansen, Hans-Henrik Tilsted ; Jensen, Lisette O ; Hvas, Anne-Mette ; Kristensen, Steen Dalby. / Patients with previous definite stent thrombosis have a reduced antiplatelet effect of aspirin and a larger fraction of immature platelets. I: J A C C: Cardiovascular Interventions ; Vol. 3, Nr. 8, s