SKABELON Foredragskonkurrence

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1 SKABELON Foredragskonkurrence Ahmed Jibril Abdi Fysiker ved Medicoteknik RSD Kløvervænget Odense C Tlf. nr.: ahmed.abdi2rsyd.dk Author: Ahmed Jibril Abdi, Medical Physicist, MSc in Medicine Clinical Engineering department, section of imaging, southern region of Denmark. Evaluation of patient dose saving in grid-less X-ray mammography acquisition compared with full field digital mammography (FFDMG) acquisition Purpose: To investigate the patient radiation dose saving of gridless X-ray mammography acquisitions compared with conventional full-field digital X-ray mammography (FFDMG). Methods and materials: The Siemens Inspiration MAMMOMAT PRIME system with Software Based Scatter Correction (SBSC) was used to investigate the dose saving in grid-less acquisition compared with conventional full-field digital mammography (FFDMG) acquisitions. A Piranha 657 solid-state detector was used to measure the entrance exposure. The entrance exposure was directly measured on different PMMA thicknesses of 20-70mm in steps of 10mm. The PMMA block thicknesses were then converted to an equivalent compressed breast tissue thicknesses. The average glandular dose (AGD) is calculated. Results: Dose reduction in both the directly measured entrance exposure and the calculated AGD is between 13% and 32% in the grid-less mammography acquisition. The contrast to noise ratio (CNR) calculated in the grid-less and the FFDMG acquisition also was the same. Conclusion: It was possible to save patient dose (13-32%) in gridless mammography acquisition without affecting the image quality. Abstrakt sendes til:

2 Foredragskonkurrence Forfatter/Kontakt person: Matteo Cesari Adresse: Rønnebærvej 26, 2840 Holte Tlf. nr.: ORAL PRESENTATION preferred. MATTEO CESARI 1, JESPER MEHLSEN 2, ANNE-BIRGITTE MEHLSEN 3 & HELGE BJARUP DISSING SORENSEN 1 1 Department of Electrical Engineering, Technical University of Denmark 2 Coordinating Research Centre, Frederiksberg Hospital 3 Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen APPLICATION OF A NEW ROBUST ECG T-WAVE DELINEATION ALGORITHM FOR THE EVALUATION OF THE AUTONOMIC INNERVATION OF THE MYOCARDIUM T-wave amplitude (TWA) is a well know index of the autonomic innervation of the myocardium. However, until now it has been evaluated only manually or with simple and inefficient algorithms. In this paper, we developed a new robust single-lead electrocardiogram (ECG) T-wave delineation algorithm that is able to detect the T-wave with a wavelet based method and automatically calculate the TWA. We evaluated the algorithm on the QT database, achieving a sensitivity of 99.92% for the T wave peak and 99.38% for the T wave end. In addition, the percentage of records automatically delineated with high precision was higher than previous published works. Finally, the algorithm was applied to study the influence of anticholinergic and antiadrenergic drugs (i.e. atropine and metoprolol) on the TWA. It was observed that atropine significantly decreased the TWA when compared to baseline level, that head-up tilt caused a decrease of TWA and that metoprolol blunted this decrease. Through the development of a robust algorithm, this study opens the way for further research on the T-wave analysis for the assessment of the autonomic innervation of the ventricular myocardium. Fig. 1: The error bars represent the mean and standard deviation for each result: (a) Comparison of the TWA in supine position during baseline and after 4 atropine boluses with continuous saline infusion ( =p<0.0001); (b) Normalized TWA with respect to the corresponding baseline levels obtained during baseline and during the first tilt up with continuous saline infusion and continuous metoprolol infusion ( =p<0.0001, *=p<0.001).

3 Foredragskonkurrence Forfatter/Kontakt person: Daniel Hansen Pedersen Adresse: Campusvej , 5230 Odense M Tlf. nr.: DANIEL HANSEN PEDERSEN Faculty of Engineering, University of Southern Denmark CONTROL INTERFACE FOR RAVEN SURGICAL ROBOT A simple and easy-to-use interface for robot controlling with base in a clinical setting is developed. The results are of interest to other stakeholders in the field of robotics where the user possess limited capabilities in robot controlling too. Initially the interface is developed and tested on the Raven II Surgical Robot but is with small modifications applicable in other contexts. The development contributes to the overall goal of developing a library of surgical procedures for clinical robots. The purpose is to enhance the training of surgeons and increase the degree of autonomy of robots during surgery. A drawing specifies the robots movement. See figure 1. It is possible to draw three dimensional and specify the orientation. The interface translates the path to coordinates and scales it according to specified workspace dimensions. The path can be interpolated to a specific resolution and sent to the robot. As an assessment, an application is developed with ability to draw and communicate with the control interface. The application is tested on 12 persons with pronounced positive results in regards to controlling a robot with a drawing, and the ease and intuitivity it was performed with. The thesis confirms the possibility to control a robot with both position and orientation from a drawing. This is evident for people with and without programming experience who found it equally easy. Fig. 1: A scenario of a surgeon indicating the movement of a robot through an interface by drawing a path. Abstrakt sendes til:

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5 SKABELON Foredragskonkurrence Forfatter/Kontakt person: Thomas Schmidt Adresse: Mærsk Mc-Kinney Møller Instituttet, SDU,Campusvej 55, 5230 Odense M Tlf. nr.: Slet eksempel og skriv abstrakt i testruden: Alle forfattere skal anføres; foredragsholderen skal understreges, max 250 ord: THOMAS SCHMIDT, UFFE KOCK WIIL The Maersk Mc-Kinney Moller Institute, University of Southern Denmark IDENTIFYING PATIENTS AT RISK OF DETERIORATION Identifying patients at risk of deterioration in emergency departments is challenging due to the variety of patients, their symptoms, issues with crowding, interdisciplinary work, and the open-ended nature of determining best treatment. Research has shown that as many as 31% of patients with normal vital values deteriorate with potentially high risk consequences. The purpose of our work is to mitigate this risk of undetected deterioration through an evaluation and design suggestions for better clinical decision support systems. Our approach takes its offset in action research based on collaboration with Fælles Akut Modtagelsen at Odense University Hospital. All vital values registered with the Philips IntelliVue monitors in the period October 2013 to September have been collected. This dataset provides unique insight into the utilization of patient monitoring in emergency departments, and we use this insight to design novel monitoring interfaces that boost the situational awareness of clinical staff. A total of aggregated vital signs were registered in the period based on 3-lead electrocardiography (respiration and heart rate), pulse oximetry (arterial oxygen saturation and pulse rate), and non-invasive cuffs (systolic and diastolic blood pressure). The results of our work are a number of actionable improvement proposals, insight into spatial and temporal characteristics of monitoring, and a prototype tored patients. Furthermore, we have devised novel monitoring metrics and assessed the potential for a multi-leveled monitoring architecture. Fig. 1: Screenshot of prototype Abstrakt sendes til:

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7 SKABELON Foredragskonkurrence Forfatter/Kontakt person: Søren Holmbjerg Schibler Adresse: Skt. Jørgens Gade 105, 1sal, 5000 Odense C Tlf. nr.: Slet eksempel og skriv abstrakt i testruden: Alle forfattere skal anføres; foredragsholderen skal understreges, max 250 ord: Søren Holmbjerg Schibler The Mærsk Mc-Kinney Møller Institute, University of Southern Denmark ONLINE TRACKING OF SURGICAL INSTRUMENTS This project has examined a method to develop a solution for tracking surgical instruments. Tracking of surgical instruments can be useful in many cases such as tele surgeries, and laparoscopy. Today surgeries such as laparoscopy, needs many resources, because the camera manually is controlled by a person, which gets the information of how to move the camera by communication with the surgeon. This often leads to incorrect movements of the camera due to loss of concentration. Therefore, this project has developed an online tracking system which is able by itself to follow the tools under a laparoscopy during an operation without human interfering. The development of the online tracking system is based on an investigation of what kind of tracking is most suitable for surgical procedures. Also, there had been spoken to surgeons who uses tracking systems during surgeries, what their considerations are about using a tracking system. The online tracking system developed during this project are able to follow the tools of the Raven 2 Surgical Robot with almost no delay, from when the tools starts to move, to when the online tracking system has centered the tools again in the image. For verification of the precision of the online tracking system, a series of trails were conducted. The results of the experiment shown great results in centering the surgical instrument. Abstrakt sendes til:

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9 SKABELON POSTERKONKURRENCE Forfatter/Kontaktperson: Laura Marie Uhrlund Jensen Adresse: Ansgargade 26, 3 sal, 5000 Odense Tlf.nr.: NINNA JENSEN, LAURA MARIE UHRLUND JENSEN BAD+ a/s, Holbæk, Studere velfærdsteknologi, Syddansk Universitet Odense. VELFÆRDTEKNOLOGI VURDERING AF DEN AUTOMATISKE BRUSEKABINE Den automatiske brusekabine fra BAD+ er en ny velfærdsteknologi i udviklingsfasen, hvor der indsamles observationer til forbedringer og videreudvikling af produktet. Den automatiske brusekabine er afprøvet i to sjællandske kommuner og der er udarbejdet en velfærdsteknologisk vurdering (VTV skabelon fra teknologisk institut). Ved implementeringen er der rejst problemstillinger omkring nedre hygiejne og ved personalets normale rutiner, ligeledes er det blevet klart, at borgernes nuværende baderutiner er på plejepersonalets præmisser. Borgerne har generelt taget godt imod den nye teknologi, demente borgere såvel som kognitivt velfungerende borger. Borgere der afprøvede prototype 1, havde svære kognitive og fysiske funktionsnedsættelser. Borgere vil have mulighed for at blive helt eller delvist selvhjulpne med teknologien, hvis deres funktionsnedsættelse er moderat og de har bevaret en del af den kognitive funktion. Medarbejderne giver udtryk for deres arbejdsmiljø forbedres, de har opnået bedre arbejdsstillinger, bliver ikke på samme måde svedige og våde som ved et normalt bad. Derudover vil den frigivne medarbejder tid kunne bruges til andre opgaver i hjemmet. De største udfordringer ved prototype 1 var tørrefunktionen ikke var varm nok til at borgerens ben og ryg blev tørre, den forbedrede funktion er nu klar til afprøvning i anden prototype. b indikere hvilke områder der er mulighed for forbedringer fra prototype 1 til prototype 2, som er for er klar til næste afprøvnings fase. Abstrakt sendes til:

10 Foredragskonkurrence Forfatter/Kontakt person: Rasmus Høegh Adresse: Stærevej 66, st. 14 Tlf. nr.: KRISTINE AAVILD JUHL & RASMUS M. TH. HØEGH Medicine and Technology, Hearing Systems, Department of Electrical Engineering, Technical University of Denmark (DTU) STRUCTURE OF SPEECH IN BINARY MASKING Speech is an essential part of human interaction, but the intelligibility of speech is impeded by noise. A recent approach for improving intelligibility is ideal binary masking. Ideal binary masks (IBMs) requires prior knowledge of the target speech and the noise, separately. To employ binary masking in practical applications, it is necessary to estimate the masks based on speech in conjunction with noise, resulting in estimated binary masks (EBMs). Estimation algorithms has been developed based on machine learning techniques such as Gaussian mixture models (GMM). Errors in the estimations are, however, detrimental to the efficiency of the technique. Also, structure in errors (a nonrandomly distribution of errors) further reduces the intelligibility. A novel approach to describe such structure is presented based on empirically determined probabilities. The structure of the EBMs are found to reflect the structure observed in IBMs, but to differ in characteristic manners and display a lower overall structure (Fig. 1). The description and analysis presented allows for modelling of the structure in EBMs, which enables systematic investigation of the implication of structure on intelligibility. This, in turns, allows for the development of better estimation algorithms. Lastly, the developed approach for describing structure also enables imposing of speech structure in the estimation, which could aid the efficiency of the binary masking technique. Fig. 1: Probability of observing a target-dominated unit at a given distance in time and ferquency for IBM and GMM respectively.

11 SKABELON Foredragskonkurrence Forfatter/Kontakt person: Mads Gleitze Smith Adresse: Øster Farigmagsgade 69C København Ø 2100 Tlf. nr.: Mads Gleitze Smith & Mathias Nørbæk Johansen Nanotech Department, DTU IN VITRO MODELS OF THE MECHANICAL AND CHEMICAL CELL MICROENVIRONMENT IN TISSUE Accurate in vitro models of human tissue are increasingly pursued for a wide range of applications including drug development, toxicology studies, personalized therapy, as well as fundamental biology research such as cancer research. The development of accurate in vitro models of cancer tumors could lead to an enhanced understanding of tumor navigation. Understanding different migration strategies employed by the individual tumor cells in complex microenvironments would contribute to the development of more accurate diagnostic techniques. The ability to predict cell migration in patients will thus provide methods for constraining tumor cell dissemination and halting metastasis formation. This presentation/poster will be based on our bachelor thesis, which worked towards creating an in vitro model of soft tissue with embedded cell clusters by combining a natural and synthetic hydrogel. The development of a simple and replicable system, that provides spatial control of the cell clusters, while allowing single cell migration in a 3D environment, will also be included. Sterolithography has been utilized to fabricate unique 3D structures with two main purposes being cell cluster formation and positioning. Furthermore a quantitative method will be introduced in order to examine the spatial distribution of cells and cell clusters. The method seeks to provide a reproducible and consistent analysis of entire 3D structures. Introducing such a tool allows investigations of various biophysical or biochemical stimuli and how they influence the spatial distribution and migration of single cells and cell clusters. Abstrakt sendes til:

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