Søgeprotokol til PICO 2

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1 Søgeprotokol til PICO 2 Dette arbejdspapir kan anvendes i forbindelse med litteratursøgningerne på de emner, der indgår i retningslinjen. Se evt. eksempel på udfyldt skema eller kontakt Retningslinjesekretariatet for bistand til udfyldelsen Emne Udfyld ét arbejdspapir for hvert emne. Titel (på retningslinje) DMCG Kontakt med metodespecialist Farmakologiske interventioner til lindring af refraktær dyspnø hos voksne kræftpatienter i sen eller terminal palliativ fase DMCG-PAL Alle litteratursøgninger er foretaget af Tina Harmer Lassen, metodekonsulent i DMCG-PAL. Senest udfyldt Afgrænsning af emne Baggrund Opdatering af klinisk retningslinje om behandling af dyspnø hos patienter med uhelbredelig kræft. Inklusionskriterier: Studiepopulation: Cancerpatienter med dyspnø Inklusions- og eksklusionskriterier Publikationsdato (periode): fra 2010 og frem (guidelines) og fra 2016 og frem (systematiske reviews og randomiserede kontrollerede forsøg). Se nedenstående bilag for afgrænsninger i de specifikke søgninger. Sprog: Engelsk, dansk, svensk, norsk, tysk Publikationstyper: systematiske reviews, meta-analyser, randomiserede kontrollerede forsøg. Emneord Specifikke søgeord fremgår endvidere af bilag for de enkelte søgninger indsat nedenfor. Population Neoplasms OR adenocarcinoma*) OR carcinoma*) OR cancer*) OR tumor*) OR tumour*) OR malignan* Dyspnea OR dyspn* OR breathless* OR "shortness of breath" OR "breathing difficulties 1

2 Intervention PICO 2: benzodiazepine* OR BenzodiazepinesOR adinazolam OR alprazolam OR bentazepam OR bromazepam OR brotizolam OR chlordiazepoxide OR cinolazepam OR clobazam OR clonazepam OR clorazepate OR clotiazepam OR cloxazolam OR delorazepam OR demoxepam OR desmethyldiazepam OR diazepam OR estazolam OR etizolam OR etizolam OR fludiazepam OR flunitrazepam OR flurazepam OR flutoprazepam OR halazepam OR haloxazolam OR ketazolam OR loprazolam OR lorazepam OR lormetazepam OR medazepam OR metaclazepam OR mexazolam OR midazolam OR nimetazepam OR nitrazepam OR nordazepam OR oxazepam OR oxazolam OR pinazepam OR prazepam OR quazepam OR temazepam OR tetrazepam OR tofisopam OR triazolam Søgning efter guidelines Databaser (Guidelines) Dato for søgning (Turning Research Into Practice) (NICE UK) (National Guideline Clearinghouse) (Scottish Intercollegiate Guidelines Network (SIGN)) (HTA Database) (The Cochrane Collaboration) (The Joanna Briggs Institute) (SBU, Sverige) (Socialstyrelsen, Sverige) (Kunnskapscenteret, Norge) (Helsedirektoratet, Norge) Søgning efter systematiske reviews 2

3 Til PICO 2: Databaser (systematiske reviews) Dato for søgning Cochrane Library Medline EMBASE CINAHL Søgning efter primærlitteratur (randomiserede kontrollerede forsøg) Til PICO 2: Databaser (primær litteratur) Dato for søgning Medline EMBASE THE COCHRANE LIBRARY CINAHL

4 Søgestrategier (kopieret ind) For hver database der søges i, kopieres selve søgningen ind herunder. Søgning på guidelines Database (Turning Research Into Practice) Dato for Søgeord søgning (dyspnea cancer) from:2010 (breathlessness cancer) from: (NICE UK) Dyspnea Dyspnoea (National Guideline Clearinghouse) (Scottish Intercollegiate Guidelines Network (SIGN)) (HTA Database) Breathlessness Dyspnea Dyspnoea Breathlessness Dyspnea Dyspnoea Breathlessness (dyspnea) AND (cancer) FROM 2010 TO 2018 (dyspnoea) AND (cancer) FROM 2010 TO 2018 (breathlessness) AND (cancer) FROM 2010 TO (The Cochrane Collaboration) (The Joanna Briggs Institute) ID Search #1 Dyspnea #2 Dyspnoea #3 Breathlessness #4 #1 or #2 or #3 #5 MeSH descriptor: [Neoplasms] explode all trees #6 cancer #7 #5 or #6 #8 #4 and # breathlessness AND cancer Dyspnea (SBU, Sverige) Andfåddhet Andnöd Dyspné (Socialstyrelsen, Sverige) (Kunnskapscenteret, Norge) (Helsedirektoratet, Norge) Andfåddhet cancer Andnöd cancer Dyspné Kortpustethet tungpustethet dyspné åndenød kortpustethet tungpustethet dyspné åndenød 4

5 Sekundær og primær litteratursøgning: PICO 2 Dato Database Søgestreng Afgrænsning Pubmed Search ((((benzodiazepine*) OR "Benzodiazepines"[Mesh]) OR (adinazolam OR alprazolam OR bentazepam OR bromazepam OR brotizolam OR chlordiazepoxide OR cinolazepam OR clobazam OR clonazepam OR clorazepate OR clotiazepam OR cloxazolam OR delorazepam OR demoxepam OR desmethyldiazepam OR diazepam OR estazolam OR etizolam OR etizolam OR fludiazepam OR flunitrazepam OR flurazepam OR flutoprazepam OR halazepam OR haloxazolam OR ketazolam OR loprazolam OR lorazepam OR lormetazepam OR medazepam OR metaclazepam OR mexazolam OR midazolam OR nimetazepam OR nitrazepam OR nordazepam OR oxazepam OR oxazolam OR pinazepam OR prazepam OR quazepam OR temazepam OR tetrazepam OR tofisopam OR triazolam))) AND (((("Dyspnea"[Mesh]) OR dyspn*) OR "shortness of breath") OR "breathing difficulties") Publiceret fra EMBASE 1 (adinazolam or alprazolam or bentazepam or bromazepam or brotizolam or chlordiazepoxide or cinolazepam or clobazam or clonazepam or clorazepate or clotiazepam or cloxazolam or delorazepam or demoxepam or desmethyldiazepam or diazepam or estazolam or etizolam or etizolam or fludiazepam or flunitrazepam or flurazepam or flutoprazepam or halazepam or haloxazolam or ketazolam or loprazolam or lorazepam or lormetazepam or medazepam or metaclazepam or mexazolam or midazolam or nimetazepam or nitrazepam or nordazepam or oxazepam or oxazolam or pinazepam or prazepam or quazepam or temazepam or tetrazepam or tofisopam or triazolam).af. 2 benzodiazepine derivative/ or exp benzodiazepine/ or benzodiazepine$.mp. 3 1 or 2 4 exp dyspnea/ or dyspn$.mp. 5 breathless$.mp. 6 (short* adj2 breath).mp. 7 breathing difficult$.mp. 8 4 or 5 or 6 or and 8 Publiceret fra CINAHL Search ID# S12 Search Terms S6 AND S10 Publiceret fra S11 S6 AND S10 S10 S7 OR S8 OR S9 S9 adinazolam OR alprazolam OR bentazepam OR bromazepam OR brotizolam OR chlordiazepoxide OR cinolazepam OR clobazam OR clonazepam OR clorazepate OR clotiazepam OR cloxazolam OR delorazepam OR demoxepam OR desmethyldiazepam OR diazepam OR estazolam OR etizolam OR etizolam OR fludiazepam OR flunitrazepam OR flurazepam OR flutoprazepam OR halazepam OR haloxazolam OR ketazolam OR loprazolam OR lorazepam OR lormetazepam OR medazepam OR metaclazepam OR mexazolam OR midazolam OR nimetazepam OR nitrazepam S8 benzodiazepine* S7 (MH "Antianxiety Agents, Benzodiazepine+") 5

6 S6 S5 S4 S3 S2 S1 OR S2 OR S3 OR S4 OR S5 breathing difficult* "shortness of breath" breathless* dyspn* Cochrane library S1 (MH "Dyspnea+") #1 MeSH descriptor: [Dyspnea] explode all trees #2 dyspn* #3 (dyspn*):ti,ab,kw #4 (breathless*):ti,ab,kw #5 ((short* near/2 breath)):ti,ab,kw #6 (breathing difficult*):ti,ab,kw #7 #1 or #2 or #3 or #4 or #5 or #6 #8 MeSH descriptor: [Benzodiazepines] explode all trees #9 (benzodiazepine*):ti,ab,kw #10 (adinazolam OR alprazolam OR bentazepam OR bromazepam OR brotizolam OR chlordiazepoxide OR cinolazepam OR clobazam OR clonazepam OR clorazepate OR clotiazepam OR cloxazolam OR delorazepam OR demoxepam OR desmethyldiazepam OR diazepam OR estazolam OR etizolam OR etizolam OR fludiazepam OR flunitrazepam OR flurazepam OR flutoprazepam OR halazepam OR haloxazolam OR ketazolam OR loprazolam OR lorazepam OR lormetazepam OR medazepam OR metaclazepam OR mexazolam OR midazolam OR nimetazepam OR nitrazepam OR nordazepam OR oxazepam OR oxazolam OR pinazepam OR prazepam OR quazepam OR temazepam OR tetrazepam OR tofisopam OR triazolam):ti,ab,kw #11 #8 or #9 or #10 #12 #7 AND #11 Publiceret