NANOKEM Afrunding, perspektiver og diskussion. Anne Thoustrup Saber, Ismo Koponen, Karin Sørig Hougaard og Frank Fotel

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1 NANOKEM Afrunding, perspektiver og diskussion Anne Thoustrup Saber, Ismo Koponen, Karin Sørig Hougaard og Frank Fotel

2 Subproject 4: Model for risk assessment (DHI) NANOKEM ( ) Subproject 1: Exposure assessment (NRCWE) Subproject 2: Physical and chemical characterization (NRCWE) International expert group Subproject 3: Toxicological effects 3.1: Translocation (NRCWE, AU) 3.2: Genotoxic effects (NRCWE, CU) 3.3 Cardiovascular effects (NRCWE, CU) 3.4: Reproduction and embryogenicity (NRCWE) 3.5: Allergy (NRCWE) Industrial advisory board: The Danish Paint- and Lacquer Industry

3 Take home message - 1 Rene nanopartikler kan forårsage lungeinflammation (Hougaard et al., 2010; Saber et al, 2011) fremme allergisk sensibilisering (Larsen et al., 2009) medføre DNA-skade (Saber et al, 2011) inducere et akutfaserespons som er en risikofaktor for hjertekar sygdom (Halapannavar et al., 2011) måske påvirke udviklingen af fostrets nervesystem (Hougaard et al., 2010)

4 Take home message - 2 Generelt påvirkede tilsætning af nanopartikler til produkter ikke emissionen af partikler i nanostørrelse ved slibning sammenlignet med konventionelle produkter (Koponen et al., 2009, 2010) Støv fra nanopartikelholdige malinger var ikke mere farligt end støv fra konventionelle produkter (Saber et al, in press) Malematricen var af større betydning for de toksiske effekter end tilsætningen af nanopartikler (Saber et al, in press) Risikovurderingen viser, at grænseværdier for nanopartikler i arbejdsmiljøet bør være lavere end for bulkmaterialer

5 Perspektiver Har vejr og vind nogen betydning for frigørelsen af nanopartikler? Kan resultaterne fra nanopartikelholdige malinger og lakker generaliseres til andre produktgrupper?

6 Nyt projekt: NanoSustain ( ) Etableret følgegruppe med repræsentanter fra Den Danske Farve Lim Industri, som ligesom i Nanokem, deltager i regelmæssige møder Flügger har produceret testmalinger EU FP7 støttet projekt (247989)

7 Nanopartikler og livs-cyklus materialer i NanoSustain Reference materiale Nanopartikel indeholdende materiale Nanomateriale Epoxy CNT-containing epoxy (0,2%) MWCNT (NANOCYL TM NC7000) EpoCyl epoxy resin-based formulation (<20%) MWCNT (NANOCYL TM NC7000) ZnO powder (ZincoxTM 10) Glass sheet coated with polysiloxane matrix without NP Glass sheets coated with ZnO-containing polysiloxane matrix (30%)* ZnO dispersion (Nano-BPS 900) (40% ZnO) Glass sheets with no coating Final product (pro.glass Barrier 401) (5% ZnO) Paint with 20,3% TiO2 (100% Nabond TiO 2) Paint with 20,3% TiO 2 (33.3% NanoAmor TiO2/66.7% NaBond TiO 2 ) NaBond TiO 2 Paint with 20,3% TiO 2 (100% NanoAmor TiO 2 ) NabBond TiO 2 Paper with cellulose Paper with nanocellulose (0,2%) Nanocellulose Nanosustain-malinger fremstilles af Lars Find Andersen, Flügger Flügger står desuden for at udsætte de malede plader for weathering

8 Mere information Nanokem: /nanopartikler-i-farve-og-lakindustrien---nanokem Nanosustain: /development-of-sustainable-solutions-fornanotechnology-based-products---nanosustain

9 Formidling publicerede artikler (peer reviewed) Halappanavar S, Jackson P, Williams A, Jensen KA, Hougaard KS, Vogel U, Yauk CL, Wallin H Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in micrornas: A toxicogenomic study. Environ Mol Mutagen. Hougaard KS, Jackson P, Jensen KA, Sloth JJ, Loschner K, Larsen EH, Birkedal RK, Vibenholt A, Boisen AM, Wallin H Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice. Part Fibre Toxicol 7:16. Koponen IK, Jensen KA, Schneider T Sanding dust from nanoparticle-containing paints: physical characterisation. Journal of Physics:ConferenceSeries 151:1-9 Koponen IK, Jensen KA, Schneider T Comparison of dust released from sanding conventional and nanoparticle-doped wall and wood coatings. J Expo Sci Environ Epidemiol. Larsen ST, Roursgaard M, Jensen KA, Nielsen GD Nano titanium dioxide particles promote allergic sensitization and lung inflammation in mice. Basic Clin Pharmacol Toxicol 106: Roursgaard M, Jensen KA, Poulsen SS, Jensen NE, Poulsen LK, Hammer M, Nielsen GD, Larsen ST Acute and subchronic airway inflammation after intratracheal instillation of quartz and titanium dioxide agglomerates in mice. ScientificWorldJournal 11: Roursgaard M, Poulsen SS, Kepley CL, Hammer M, Nielsen GD, Larsen ST Polyhydroxylated C60 fullerene (fullerenol) attenuates neutrophilic lung inflammation in mice. Basic Clin Pharmacol Toxicol 103: Roursgaard M, Poulsen SS, Poulsen LK, Hammer M, Jensen KA, Utsunomiya S, Ewing RC, Balic-Zunic T, Nielsen GD, Larsen ST Time-response relationship of nano and micro particle induced lung inflammation. Quartz as reference compound. Hum Exp Toxicol. Saber AT, Jensen KA, Jacobsen NR, Birkedal RK, Mikkelsen L, Møller P, Loft S, Wallin H, Vogel U. 2011a. Inflammatory and genotoxic effects of nanoparticles designed for inclusion in paints and lacquers. Nanotoxicology Saber AT, Koponen IK, Jensen KA, Jacobsen NR, Mikkelsen L, Møller P, Loft S, Vogel U, Wallin H. 2011b. Inflammatory and genotoxic effects of sanding dust generated from nanoparticle-containing paints and lacquers. Nanotoxicology (in press).

10 Formidling rapporter og proceedings Mikkelsen L. PhD thesis: Cardiovascular health effects of paint dust with and without nanoparticles compared to the primary nanoparticles Faculty of Health Sciences, University of Copenhagen. Roursgaard M. PhD thesis: Inflammatory effects of nanoparticles in lungs of mice Faculty of Health Sciences. Saber AT, Jensen KA, Hougaard KS, Koponen IK, Larsen ST, Jacobsen NR, Birkedal RK, Fotel F, Roursgaard M, Mikkelsen Let al NANOKEM: Nanoparticles in the Paint and Lacquer Industry. Exposure and Toxic Properties. Cracow University of Technology pp. Kristensen HV, Hansen SBHGR, Jensen KA, Koponen IK, Saber AT, Nielsen SH, Wallin H Nanopartikler i arbejdsmiljøet Industriens Branchearbejdsmiljøråd, Branchearbejdsmiljørådet for Undervisning og Forskning, Universitets- og Bygningsstyrelsen. Saber AT et al., NANOKEM 2010: Nanoparticles in the paint- and lacquer industry. Exposure and toxic properties, Compendium of Projects in the European NanoSafety Cluster, Michael Riediker and Georgios Katalagarianakis (Eds.), Lausanne, Switzerland: Institute for Work and Health, pp. (

11 Tak til Farve-lak Anette Harbo Dahl (Danmarks Farve- og Limindustri) Lars Find Andersen, Flügger Thomas Sørensen, Beck & Jørgensen Steen Karlsen, Boesens Fabrikker Beth Gydesen, Akzo Dorthe Brejndahl, Teknos Per Langholz, Dyrup Arbejdsmiljøforskningsfonden NFA Håkan Wallin Ulla Vogel Keld Alstrup Jensen Ismo Kalevi Koponen Karin Sørig Hougaard Nicklas Raun Jacobsen Renie Birkedal Lourdes Pedersen Elzbieta Christiansen Michael Guldbrandsen Gitte Kristiansen Maria Hammer KU Lone Mikkelsen Steffen Loft Peter Møller DHI Frank Leck Fotel