Søgeprotokol for Nationale Kliniske Retningslinjer

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1 Søgeprotokol for Nationale Kliniske Retningslinjer Projekttitel/aspekt NKR for brug af antibiotika ved tandlægebehandling søgning på primærlitteratur Fagkonsulent /projektleder Bjarne Klausen / Christina Debes Helm, SST Søgespecialist Jette Frost Jepsen, Aalborg Universitetshospital, Medicinsk Bibliotek Senest opdateret 4. maj 2016 Baggrund Søgetermer Inklusions- og eksklusionskriterier PICO 1 Bør patienter med odontogene abscesser tilbydes antibiotika, hvis deres almentilstand ikke er påvirket af infektionen? PICO 2 Bør man anvende penicillin V alene eller i kombination med metronidazol ved behandling af odontogene abscesser hos personer, hvis almentilstand er påvirket af infektionen? PICO 3 Bør patienter tilbydes profylaktisk antibiotikum i forbindelse med indsættelse af implantater uden knogleopbygning? PICO 4 Bør patienter tilbydes profylaktisk antibiotikum i forbindelse med indsættelse af implantater med knogleopbygning? PICO 5 Bør patienter tilbydes profylaktisk antibiotikum i forbindelse med dentoalveolær kirurgi? PICO 6 Bør man i forbindelse med ekstraktioner og andre indgreb i kæbeknoglen tilbyde antibiotika til patienter i behandling med antiresorptive medikamenter? PICO 7 Bør man tilbyde antibiotika ved behandling af marginal parodontitis hos voksne patienter med sufficient mundhygiejne, hvis sygdommen ikke responderer på mekanisk infektionsbehandling? PICO 8 Bør man tilbyde antibiotika ved behandling af periimplantitis hos patienter, som har sufficient mundhygiejne, men responderer dårligt på mekanisk infektionsbehandling? PICO 9 Bør man anvende metronidazol alene eller i kombination med amoxicillin som supplement til mekanisk infektionsbehandling af marginal parodontitis hos voksne med sufficient mundhygiejne, hvis sygdommen ikke responderer på sufficient mekanisk infektionsbehandling? PICO 10 Bør man anvende amoxicillin alene eller i kombination med metronidazol som supplement til mekanisk infektionsbehandling af marginal parodontitis hos patienter med sufficient mundhygiejne, hvis sygdommen ikke responderer på sufficient mekanisk infektionsbehandling? Se søgestrategierne under de enkelte PICOs Sprog: Engelsk, dansk, norsk og svensk År: Sidste 10 år ( ) Publikationstype: controlled clinical trials, randomized controlled trials / RCT 1

2 Informationskilder DATABASE INTERFACE DATO FOR SØGNING OVID EMBASE OVID Søgningen til PICO 4 er foretaget 4. maj 2016 Note Søgetermer og inklusions- og eksklusionskriterier er tilpasset de enkelte databaser. Dubletter er så vidt muligt frasorteret ved hjælp af RefWorks. De fundne referencer overføres til Covidence (referenceværktøj) Fuldtekster præsenteres i Covidence i pdf-format Søgestrategi for hver enkelt database præsenteres hvis muligt vises det eksplicit hvor mange referencer den enkelte søgestreng genererer. 2

3 Søgestrategi primærlitteratur PICO 1 (89 referencer efter dubletsøgning) 1 Periodontal Abscess/ Periapical Abscess/ Pericoronitis/ periodontal abscess*.mp Periapical Abscess*.mp pericoronitis.mp (apical adj2 abscess*).mp dental abscess*.mp (tooth adj3 abscess*).mp (teeth adj3 abscess*).mp or/ exp Anti-Bacterial Agents/ Antibiotic Prophylaxis/ exp Penicillins/ exp Amoxicillin/ Metronidazole/ drug therapy.fs antibiotic*.mp anti-bacterial agent*.mp (antibiotic* adj3 prophyla*).mp penicillin*.mp amoxicillin.mp metronidazole.mp or/ and (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,sh. 27 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj2 (blind* or mask*))).ti,ab,kw,sh or and limit 25 to (controlled clinical trial or randomized controlled trial) or limit 31 to (yr="2006 -Current" and (danish or english or norwegian or swedish)) 15 Embase 1 periodontal abscess/ tooth abscess/ periodontal abscess*.mp Periapical Abscess*.mp pericoronitis.mp (apical adj2 abscess*).mp dental abscess*.mp

4 8 (Teeth adj3 abscess*).mp (tooth adj3 abscess*).mp or/ exp antibiotic agent/ antibiotic prophylaxis/ exp penicillin derivative/ amoxicillin/ metronidazole/ drug therapy.fs antibiotic*.mp anti-bacterial agent*.mp (antibiotic* adj3 prophyla*).mp penicillin*.mp amoxicillin.mp metronidazole.mp or/ and limit 24 to (randomized controlled trial or controlled clinical trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,sh. 27 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj2 (blind* or mask*))).ti,ab,kw,sh or and or limit 30 to ((danish or english or norwegian or swedish) and yr="2006 -Current") 82 PICO 2 (0 referencer) 1 Periodontal Abscess/ Periapical Abscess/ Pericoronitis/ periodontal abscess*.mp periapical abscess*.mp pericoronitis.mp (apical adj2 abscess*).mp dental abscess*.mp ((tooth or teeth) adj3 abscess*).mp or/ Penicillin V/ penicillin v.mp or/ Metronidazole/ metronidazole.mp or/ and 13 and limit 17 to (controlled clinical trial or randomized controlled trial) 1 19 (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,sh. 20 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple)

5 adj2 (blind* or mask*))).ti,ab,kw,sh or and or limit 23 to (yr="2006 -Current" and (danish or english or norwegian or swedish)) 0 Embase 1 periodontal abscess/ tooth abscess/ periodontal abscess*.mp periapical abscess*.mp pericoronitis.mp (apical adj2 abscess*).mp dental abscess*.mp ((tooth or teeth) adj3 abscess*).mp or/ penicillin V/ penicillin v.mp or/ metronidazole/ metronidazole.mp or/ and 12 and limit 16 to (randomized controlled trial or controlled clinical trial) 0 18 (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,sh. 19 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj2 (blind* or mask*))).ti,ab,kw,sh or and or 21 0 PICO 3 (39 referencer efter dubletsøgning) 1 exp Dental Implantation/ Dental Implants/ dental implant*.mp (tooth adj3 implant*).mp or/ Antibiotic Prophylaxis/ prophyla*.mp or/ and limit 9 to (controlled clinical trial or randomized controlled trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw

6 13 ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or/ and or limit 16 to (yr="2006 -Current" and (danish or english or norwegian or swedish)) 36 Embase 1 tooth implant/ tooth implantation/ dental implant*.mp (tooth adj3 implant*).mp or/ antibiotic prophylaxis/ prophyla*.mp or/ and limit 9 to (randomized controlled trial or controlled clinical trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or/ and or limit 16 to ((danish or english or norwegian or swedish) and yr="2006 -Current") 26 PICO 4 (33 referencer efter dubletsøgning) 1 Sinus Floor Augmentation/ (sinus floor adj3 (elevat* or augment* or lift*)).mp or exp Anti-Bacterial Agents/ Antibiotic Prophylaxis/ exp Penicillins/ exp Amoxicillin/ Metronidazole/ drug therapy.fs antibiotic*.mp anti-bacterial agent*.mp (antibiotic* adj3 prophyla*).mp penicillin*.mp amoxicillin.mp metronidazole.mp or/ and limit 17 to (controlled clinical trial or randomized controlled trial) 3 19 (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or

7 20 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or/ and or limit 24 to (yr="2006 -Current" and (danish or english or norwegian or swedish)) 2 Embase 1 sinus floor augmentation/ (sinus floor adj3 (elevat* or augment* or lift*)).mp or exp antibiotic agent/ antibiotic prophylaxis/ exp penicillin derivative/ amoxicillin/ metronidazole/ drug therapy.fs antibiotic*.mp anti-bacterial agent*.mp (antibiotic* adj3 prophyla*).mp penicillin*.mp amoxicillin.mp metronidazole.mp or/ and limit 17 to (randomized controlled trial or controlled clinical trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or/ and or limit 24 to ((danish or english or norwegian or swedish) and yr="2006 -Current") 32 PICO 5 Der blev fundet et helt opdateret systematisk review, og det blev derfor ikke fundet nødvendigt at søge yderligere primærlitteratur. 7

8 PICO 6 (25 referencer efter dubletsøgning) 1 exp Surgery, Oral/ exp Oral Surgical Procedures/ Apicoectomy/ Tooth Extraction/ Molar, Third/su [Surgery] "Tooth Root"/su [Surgery] oral surgery.mp oral surgical procedur*.mp apicoectomy.mp dentoalveolar surgery.mp ((root* or tooth or teeth or molar*) adj3 (amputat* or surg* or remov* or extract* or impact*)).mp. 12 decoronation.mp or/ exp Anti-Bacterial Agents/ Antibiotic Prophylaxis/ exp Penicillins/ exp Amoxicillin/ Metronidazole/ drug therapy.fs antibiotic*.mp anti-bacterial agent*.mp (antibiotic* adj3 prophyla*).mp penicillin*.mp amoxicillin.mp metronidazole.mp or/ exp Diphosphonates/ exp Bone Density Conservation Agents/ Denosumab/ bisphosphonate*.mp diphosphonate*.mp antiresorptive*.mp bone resorption inhibit*.mp denosumab.mp or/ and 26 and limit 36 to (controlled clinical trial or randomized controlled trial) 6 38 (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or/ and or limit 43 to (yr="2008 -Current" and (danish or english or norwegian or swedish)) 7 8

9 Embase 1 exp oral surgery/ tooth extraction/ molar tooth/su [Surgery] "tooth root"/su [Surgery] oral surgery.mp oral surgical procedur*.mp apicoectomy.mp dentoalveolar surgery.mp ((root* or tooth or teeth or molar*) adj3 (amputat* or surg* or remov* or extract* or impact*)).mp. 10 decoronation.mp or/ exp antibiotic agent/ antibiotic prophylaxis/ exp penicillin derivative/ amoxicillin/ metronidazole/ drug therapy.fs antibiotic*.mp anti-bacterial agent*.mp (antibiotic* adj3 prophyla*).mp penicillin*.mp amoxicillin.mp metronidazole.mp or/ exp bisphosphonic acid derivative/ bone density conservation agent/ denosumab/ bisphosphonate*.mp diphosphonate*.mp antiresorptive*.mp bone resorption inhibit*.mp denosumab.mp or/ and 24 and limit 34 to (randomized controlled trial or controlled clinical trial) 7 36 (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or/ and or limit 41 to ((danish or english or norwegian or swedish) and yr="2008 -Current") 22 9

10 PICO 7 (109 referencer efter dubletsøgning) 1 Periodontitis/ Aggressive Periodontitis/ Chronic Periodontitis/ periodontitis.mp ((refract* or aggressive or chronic*) adj2 periodont*).mp or/ exp Anti-Bacterial Agents/ Antibiotic Prophylaxis/ exp Penicillins/ exp Amoxicillin/ Metronidazole/ drug therapy.fs antibiotic*.mp anti-bacterial agent*.mp (antibiotic* adj3 prophyla*).mp penicillin*.mp amoxicillin.mp metronidazole.mp or/ and limit 20 to (controlled clinical trial or randomized controlled trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or/ and or limit 27 to (yr="2014 -Current" and (danish or english or norwegian or swedish)) 60 Embase 1 periodontitis/ aggressive periodontitis/ chronic periodontitis/ periodontitis.mp ((refract* or aggressive or chronic*) adj2 periodont*).mp or/ exp antibiotic agent/ antibiotic prophylaxis/ exp penicillin derivative/ amoxicillin/

11 11 metronidazole/ drug therapy.fs antibiotic*.mp anti-bacterial agent*.mp (antibiotic* adj3 prophyla*).mp penicillin*.mp amoxicillin.mp metronidazole.mp or/ and limit 20 to (randomized controlled trial or controlled clinical trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or/ and or limit 27 to ((danish or english or norwegian or swedish) and yr="2014 -Current") 84 PICO 8 (29 referencer efter dubletsøgning) 1 Peri-Implantitis/ peri-implantitis.mp periimplantitis.mp peri implantitis.mp or/ exp Anti-Bacterial Agents/ Antibiotic Prophylaxis/ exp Penicillins/ exp Amoxicillin/ Metronidazole/ drug therapy.fs antibiotic*.mp anti-bacterial agent*.mp (antibiotic* adj3 prophyla*).mp penicillin*.mp amoxicillin.mp metronidazole.mp or/ and limit 19 to (controlled clinical trial or randomized controlled trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,sh. 22 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj2 (blind* or mask*))).ti,ab,kw,sh or and or limit 25 to (yr="2012 -Current" and (danish or english or norwegian or swedish)) 22 11

12 Embase 1 periimplantitis/ peri-implantitis.mp periimplantitis.mp peri implantitis.mp or/ exp antibiotic agent/ antibiotic prophylaxis/ exp penicillin derivative/ amoxicillin/ metronidazole/ drug therapy.fs antibiotic*.mp anti-bacterial agent*.mp (antibiotic* adj3 prophyla*).mp penicillin*.mp amoxicillin.mp metronidazole.mp or/ and limit 19 to (randomized controlled trial or controlled clinical trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,sh. 22 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj2 (blind* or mask*))).ti,ab,kw,sh or and or limit 25 to ((danish or english or norwegian or swedish) and yr="2012 -Current") 24 PICO 9 og 10 (15 referencer efter dubletsøgning) 1 Periodontitis/ Aggressive Periodontitis/ Chronic Periodontitis/ periodontitis.mp ((refract* or aggressive or chronic*) adj2 periodont*).mp or/ exp Amoxicillin/ Metronidazole/ amoxicillin.mp metronidazol*.mp or/ and limit 12 to (controlled clinical trial or randomized controlled trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw

13 16 ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or/ and or limit 19 to (yr="2015 -Current" and (danish or english or norwegian or swedish)) 14 Embase 1 periodontitis/ aggressive periodontitis/ chronic periodontitis/ periodontitis.mp ((refract* or aggressive or chronic*) adj2 periodont*).mp or/ amoxicillin/ metronidazole/ amoxicillin.mp metronidazol*.mp or/ and limit 12 to (randomized controlled trial or controlled clinical trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or/ and or limit 19 to ((danish or english or norwegian or swedish) and yr="2015 -Current") 5 13