Pharmacologyonline 1: (2010)
|
|
- Gerda Iversen
- 4 år siden
- Visninger:
Transkript
1 I FLUE CE OF TRA DOLAPRIL TREATME T WITH GLIPIZIDE O SERUM GLUCOSE A D POTASSIUM LEVELS I ORMAL A D DIABETIC RATS Md Shamsuddin Munawar 1, T.Shivaraj Gouda 1*,. Venkata Rao 1, Dr.Md.Shalam 1, Dr.S.M. Shantakumar 2 1. Department of Pharmacology, V.L. College of Pharmacy, Manikprabhu Temple Road, Raichur Department of Pharmachemistry, V.L. College of Pharmacy, Manikprabhu Temple Road, Raichur-843 * Corresponding Author T.Shivaraj Gouda, Asst. Professor Department of Pharmacology, V.L. College of Pharmacy, Raichur-843. Cell no shams_secrets@yahoo.co.in Summary The aim of the study was to assess the influence of trandolapril on glipizide action in normal and diabetic rats using single and repeated dose treatments of selected doses of trandolapril. In this study blood samples were collected from tail vein for estimation of serum glucose and potassium. Trandolapril significantly altered the peak effect and enhanced the hypoglycemic activity in both normal and diabetic rats at single and repeated dose treatment. It has also increased the serum potassium levels. This suggests that, the dose and frequency of glipizide must be readjusted when it is to be used concomitantly with trandolapril. Key words: Glipizide; trandolapril; glucose; potassium; hypoglycemic. 99
2 Introduction Diabetes mellitus is estimated to be the fifth leading cause of death globally and the risk of cardiovascular disease is higher in diabetic subjects compared to non-diabetics. Diabetes is a growing problem, in 3 it was estimated that approximately 194 million people had diabetes, in 7 the total was 246 million. Of these, the majority (9%) had type 2 diabetes mellitus (T2DM). By, the number is expected to rise to 38 million 1. Insulin resistance plays a causal role in hypertension and atherosclerosis, and thus is present to some degree in most patients with these diseases. About % of hypertensive individuals are hyperinsulinemic and up to 7% of people with type 2 diabetes have hypertension. Abnormal glucose metabolism is seen in approximately two of three patients presenting with an acute coronary syndrome (with about equal numbers of patients having impaired fasting glucose and overt diabetes) 2 Recent studies indicate that ACE inhibitors can improve insulin sensitivity during either short-term or long-term administration. Rett et al. reported that insulin sensitivity increased in normotensive patients with NIDDM about min after oral administration of captopril. Torlone et al. reported that a 2-day treatment with captopril improved insulin sensitivity in hypertensive NIDDM patients. Rett et al. have suggested the contribution of bradykinin, although this is still not widely accepted 3. An increased incidence of severe hypoglycemic episodes in patients with type 2 diabetes treated with ACE inhibitors was previously described in some case-control studies. Interestingly, the highest risk of severe hypoglycemia among all patients on oral antidiabetic agents observed was in those patients concomitantly treated with ACE inhibitors and oral hypoglycemic agents. Apart from systematic studies, a number of case reports seem to confirm an increased risk of hypoglycemia in patients with diabetes treated with ACE inhibitors. For example, Arauz-Pacheco and colleagues reported two patients with stable noninsulin dependent diabetes treated with sulfonylurea in whom hypoglycemic episodes occurred almost immediately after the initiation of ACE-inhibitor therapy for hypertension. Conversely, no episodes had occurred in these patients earlier, when on glibenclamide monotherapy. 991
3 The mechanisms leading to hypoglycemic episodes in the presence of ACE inhibitors are still a matter of debate. Some authors suggest an increase of insulin sensitivity in patients with type 2 diabetes due to ACE inhibitor use, but these findings are controversial. Furthermore, a randomized, controlled, doubleblind study investigating the effects of ACE inhibitors compared to placebo on insulin sensitivity remains to be published. Other than improved sensitivity to insulin, altered pharmacokinetic or pharmacodynamic properties of the antidiabetic drug might be another reason for the observed increased lowering of blood glucose levels. Therefore, the goal of this study was to evaluate whether pharmacokinetic or pharmacodynamic interactions exist when enalapril is coadministered with glibenclamide in healthy, normotensive volunteers. 4 Materials and Methods Animals: Wistar albino rats of either sex (17-g) were procured from Sri Venkateswara Enterprises, Bangalore, and were maintained under standard husbandry conditions (temperature of ± 1 C; RH 4 to % and 12: 12 light/dark cycle). Animals were on fasting for 18 hours before commencing the experiment. During this period, they were given water ad libitum. The fasting was continued till the completion of the experiment. The experiment was performed after prior approval of the study protocol by the institutional animal ethical committee of V.L. College of pharmacy, Raichur, India. The study was conducted in accordance with the guidelines provided by Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA). Drugs and Chemicals: Glipizide was obtained as a gift sample from Sun pharma ltd., Mumbai and Trandolapril as gift sample from Medreich Sterilab Ltd., Bangalore, Karnatataka, India. Streptozotocin was purchased from Sigma-Aldrich, Bangalore. Kit for biochemical estimation of glucose was procured from Span diagnostics Ltd. Sachin (Surat), India and estimation was carried by GOD/POD method using semi autoanalyser (ERBA mannheim, CHEM- plus v 2 ). Kit for biochemical estimation of potassium was procured 992
4 from Crest biosystems, Goa, India and estimation was carried by turbidometric method using semi autoanalyser (ERBA mannheim, CHEM- plus v 2 ). The percentage reduction in serum glucose and potassium levels at time t was calculated by using the following equation. Percentage reduction in serum glucose at time t t = A-B/A Where A is serum glucose concentration at time and B is serum glucose concentration at time t. Percentage increase in serum potassium at time t t = B-A/A Where A is serum potassium concentration at time and B is serum potassium concentration at time t. Experimental design: The whole study was divided into 3 phases. In I phase the effect of trandolapril (low dose, LD 2. mg/kg, intermediate dose, ID mg/kg, medium dose, MD mg/kg and high dose, HD 12 mg/kg p.o) and glipizide ( mg/kg, p.o) were established individually on the serum glucose and potassium levels in normal rats. In II phase effect of single day treatment of trandolapril (LD 2. mg/kg, ID mg/kg, MD mg/kg and HD 12 mg/kg, p.o) and repeated treatment of trandolapril (LD 2. mg/kg, ID mg/kg, MD mg/kg and HD 12 mg/kg, p.o) for 7 days on the serum glucose and potassium levels in normal rats were studied. In III phase the possibility of drug-drug interaction between trandolapril and glipizide in diabetic conditions were explored by following the above procedure using streptozotocin (STZ) induced diabetic rats. h blood samples were collected for fasting serum glucose and potassium levels estimation. Trandolapril (p.o) and Glipizide (p.o) was administered orally to all the rats and the blood samples were collected at prefixed time intervals i.e.., 1., 2., 4., 6., 8., 12., 18., 24. and 3. h and were analyzed for serum glucose and potassium levels. 993
5 Induction of diabetes : Rats of either sex weighing (17-g) were selected and fasted for 18 hours prior to experiment and water supplied ad-libitum. The rats were administered with 6mg/kg of Streptozotocin i.p. which was prepared freshly at the time of administration in citrate buffer (ph 4.4,.1M) and was used within minutes of its preparation. After one week, the blood samples were collected and analyzed for serum glucose levels. Rats with serum glucose levels more than mg/dl were included in the experiment. In our experiment diabetes was characterized by weight loss and hyperglycemia and these animals were used for antidiabetic study. Statistical analysis: Results are expressed as mean ± SEM. Statistical differences between means were analyzed using one-way ANOVA followed by Dunnett s- t test and P<. was considered as significant. The statistical analysis was performed using demo version of Instat software (Graph pad Inc., Santabara, CA). Results In the first phase of the study in different groups of normal rats the effect of single dose treatment of trandolapril LD, ID, MD and HD and glipizide ( mg/kg, p.o) on serum glucose levels were studied. Trandolapril 2. mg/kg, p.o. (LD), mg/kg, p.o. (ID) when administered as single doses to normal rats it has significantly reduced serum glucose levels at 2, 4, 6, 8 12 and 18 th h of the experimental study. Trandolapril with MD and HD i.e. mg/kg, p.o. and mg/kg HD, p.o when administered as single doses have significantly reduced the serum glucose levels through out the experimental study except at. h. Glipizide has produced a significant hypoglycemic effect and the peak hypoglycemic effect was observed at 6 th h. Trandolapril LD, ID, MD and HD have not altered the onset of action of glipizide, but slightly increased peak effect with no change in duration of glipizide in normal rats. After repeated treatment with trandolapril LD, ID, MD and HD for 7 days it has not altered the onset of hypoglycemic action of glipizide but with a positive influence on the peak hypoglycemic effect and a significant enhancement in the duration of action. 994
6 Repeated treatment of Trandolapril LD and ID administered for 7 days followed by single dose of glipizide has not altered the hypoglycemic activity of glipizide upto 1 h but later there was a significant decrease in the serum glucose levels at 2, 6, 8, 12 th h. Similarly, repeated Trandolapril MD treated group had shown significant serum glucose reduction from 2 to 18 th h and also at 24 th h of the study period and HD had shown its significant hypoglycemic effect on glipizide from 2 nd h till the end of the experimental period (fig 1 and 2). In diabetic rats, glipizide as a single dose exhibited significant serum glucose reduction from. to 18 h of experimental study and the peak antidiabetic effect was at observed at 6 th h. Single dose of trearment of Trandolapril (LD) in diabetic rats has produced significant decrease in serum glucose levels from 2 to 12 th h, ID from 1 to 12 th h, MD from 2 to 12 th h and HD produced significant decrease in serum glucose levels from 1 to 18 th h of experimental study. In case of diabetic rats, single dose treatment of Trandolapril LD followed by single dose of glipizide has shown significant increase in the antidiabetic effect of glipizide at 2, 4, 12, 24 and 3 th h. Trandolapril ID single dose followed by single dose of glipizide had produced significant increase in antidiabetic activity of glipizide from 2 nd hour to the end of the study period except at 8 h. Trandolapril MD and HD as single doses followed by single dose of Glipizide has shown significant antidiabetic activity of glipizide from 1st h of administration of glipizide to the end of the study period (fig 3). In case of repeated treatment of various doses of Trandolapril, LD has shown significant increase in antidiabetic activity of glipizide through out the study period except at 1 and 3 th h. Repeated administration of ID for 7 days has significantly increased the antidiabetic effect of glipizide through out the study period except at 18 th h. Similarly, repeated treatment of MD and HD for 7 days has significantly altered antidiabetic effect of single dose of glipizide through out the study period (fig 4). In normal rats single doses of Trandolapril LD, ID, MD and HD followed by single dose of glipizide treatment significantly increased the serum potassium levels from 4 th h till the completion of the study. In this case Trandolapril LD has increased at 4, 6, 8, 12 and 24 th h, ID and MD at 4, 6, 8, 12, 18 and 24 th h and HD at 4, 6, 8, 12 and 18 th h (fig ). 99
7 Repeated dose treatment of Trandolapril LD, ID, MD and HD followed by single dose of glipizide treated groups have shown significant increase in the potassium levels from 4 th h till the end of experimental study (fig 6). In diabetic rats single doses of Trandolapril LD, ID and MD followed by single dose of glipizide treatment significantly increased the serum potassium levels at 2, 4, 6, 12, 18 and 24 th h, HD has increased at 1, 2, 6, 12, 18 and 24 th h. In repeated dose treatment of Trandolapril LD, ID, MD and HD followed by single dose of glipizide treated groups there was significant increase in the potassium levels from 1 st h till the end of experimental study (fig 7 and 8). This reveales a positive interaction between glipizide and trandolapril with concomitant treatment as the potassium levels were significantly elevated both in single and repeated dose treatment of trandolapril along with single dose of glipizide. 6 GLIPIZIDE ( mg/kg ) % REDUCTIO I SERUM GLUCOSE Fig.1. Percentage reduction in serum glucose with single dose treatment of Trandolapril (2.,, and mg/kg) + glipizide ( mg/kg) in normal rats 996
8 6 6 % REDUCTIO I SERUM GLUCOSE GLIPIZIDE ( mg/kg) Fig.2. Percentage reduction in serum glucose with repeated treatment of Trandolapril (2.,, and mg/kg) + single dose of glipizide( mg/kg) in normal rats % REDUCTIO I SERUM GLUCOSE GLIPIZIDE ( mg/kg) Fig. 3. Percentage reduction in serum glucose with single dose treatment of Trandolapril (2.,, and mg/kg) + single dose of glipizide (mg/kg) in diabetic rats. 997
9 % REDUCTIO I SERUM GLUCOSE GLIPIZIDE ( mg/kg) Fig. 4. Percentage reduction in serum glucose with repeated treatment of Trandolapril (2.,, and mg/kg) + single dose of glipizide ( mg/kg) in diabetic rats. % I CREASE I SERUM POTASSIUM. GLIPIZIDE ( mg/kg) Fig.. Percentage increase in serum potassium with single dose treatment of Trandolapril (2.,, and mg/kg) + glipizide ( mg/kg) in normal rats. 998
10 % I CREASE I SERUM POTASSIUM GLIPIZIDE (mg/kg) Fig. 6. Percentage increase in serum potassium with repeated treatment of Trandolapril (2.,, and mg/kg) + glipizide ( mg/kg) in normal rats 3 % I CREASE I SERUM POTASSIUM GLIPIZIDE ( mg/kg) Fig. 7. Percentage increase in serum potassium with single dose treatment of Trandolapril (2.,, & mg/kg) + glipizide ( mg/kg) in diabetic rats. 999
11 4 GLIPIZIDE ( mg/kg) 3 % I CREASE I SERUM POTASSIUM fig. 8. percentage increase in serum potassium with repeated treatment of trandolapril (2.,, & mg/kg) + glipizide ( mg/kg) in diabetic rats. Discussion Ever since the discovery of insulin and sulfonylureas as clinically useful antidiabetic agents, control of blood sugar level with drug(s) has been the primary objective in diabetic patients. Simultaneous use of other drugs is the usual event in the life of these patients. So, drug interactions between antidiabetic agents and other classes of drugs, affecting the safety and/or efficacy of these drugs, are likely to occur. The severity of the situation is clearly reflected by data collected from the literature by Seltzer who recorded 473 cases of drug induced hypoglycemia of which 6 were fatal. The survey included 2 cases of hypoglycemia induced by sulfonylureas only of which were fatal. 6 The present study was under taken to verify the possible drug-drug interaction if any between single and repeated dose treatment of trandolapril on hypoglycemic and antidiabetic activity of glipizide in normal and diabetic rats. The effect of trandolapril on serum potassium levels after single and repeated dose treatment was also studied.
12 In the present study in normal animals the effect of trandolapril on the hypoglycemic and antidiabetic activity of glipizide was studied and parameters considered for the study were onset and duration of hypoglycemic action of glipizide. After repeated dose treatment of trandolapril followed by single dose treatment of glipizide, it has shown significant hypoglycemia in all the animals, exhibited by reduced activity (movement), confined to a single place with signs of depression which was further confirmed by significant increase in duration of hypoglycemic activity of glipizide and slight alteration in peak effect after trandolapril pre treatment. The results have indicated that trandolapril has influenced the absorption phase of glipizide. Since the peak effect and duration of hypoglycemia induced by glipizide were enhanced, so it can be concluded that trandolapril appears primarily to interfere with the absorption, protein binding or metabolism, excretion, increase in micro and macro vascular circulation to pancreas and decreased insulin resistance. Hypertension and diabetes mellitus are two common chronic conditions which frequently coexist and can significantly affect individual health care needs 7. The prevalence of hypertension increases with age and is common in both cases of insulindependent diabetes mellitus (IDDM) and non insulin-dependent diabetes mellitus (NIDDM) conditions. Hypertension appears to be critically important in diabetes mellitus, not only because of its increased prevalence, but also it accelerates both the micro vascular and macro vascular complications of diabetes. Combination of hypertension and diabetes mellitus produces greater myocardial dysfunction and is associated with significant mortality rates. Hence controlling blood pressure in diabetics is positively more beneficial as far as progressions of diabetic complications are concerned. ACE inhibitors can help people with diabetes by reducing their risk of heart attack, stroke and premature deaths and also delay the onset and progression of kidney disease. In addition, ACE inhibitors can help to reduce other complications of diabetes such as foot ulcers and eye damage (retinopathy), as retinopathy is the leading cause of blindness for people with diabetes. People who take ACE inhibitors run a slightly increased risk of low blood sugar. Therefore, people with diabetes, should closely monitor blood sugar levels for the first few weeks after starting with ACE inhibitor, or 1
13 during an increase in the dosage of ACE inhibitor. ACE inhibitor therapy appears to improve insulin sensitivity and glucose metabolism. Improvement in insulin sensitivity was achieved by addition of an ACE inhibitor to a tissue culture system, suggesting effects independent of the microcirculation. This improvement in insulin sensitivity at a cellular level is indicated by an increase in glucose transporter 4 protein and activity of hexokinase, a key enzyme in glucose metabolism in the skeletal muscle of obese rats treated with an ACE inhibitor. Several studies have shown that ACE inhibitors and ARBs (angiotensin receptor blockers) decrease the incidence of new-onset type 2 diabetes. A possible protective effect of ARBs and ACE inhibitors on the pancreatic β-cell through inhibiting the vasoconstrictive effect of angiotensin II in the pancreas and increasing islet blood flow, which could improve insulin release by β-cells 2. ACE inhibitors increases potassium levels in the body and the same in diabetes mellitus increases effect of insulin on control of blood sugar. Concurrent use of ACE inhibitors and hypoglycemic agents usually appears to be uneventful but hypoglycemia, marked in some instances and has occurred in small number of diabetic patients taking insulin or sulfonylurea when treated with ACE inhibitors. This has been attributed, but not proved, to be due to an interaction. The problem was solved in some cases by reducing the dosage of hypoglycemic agent. Clinically ACE inhibitors are one of the drugs of choice in patients who are diabetic with mild to severe hypertension. Concomitant administration of ACE inhibitors with oral hypoglycemic agents or insulin therapy has been reported. At the same time the risk of hypoglycemia was increased 3.- flod in patients taking insulin or hypoglycemic agent with ACE inhibitors. ACE inhibitors could improve the blood circulation in skeletal muscles, thus favoring peripheral insulin action, but also in the pancreas, thus promoting insulin secretion. Conclusion The present study suggests that during simultaneous treatment for hypertension and diabetes with lisinopril and glipizide the dose and frequency of glipizide has to be readjusted accordingly to avoid severe hypoglycemia. 2
14 Acknowledgements The authors wish to thank all management members, AME s V.L. College of Pharmacy, Raichur (Karnataka) for providing the necessary facility to carryout this research work with great ease and precission. References 1. Digital comprehensive summaries of uppsala dissertations From the faculty of pharmacy 71 Safety and efficacy modelling in Anti-diabetic drug development Bengt hamrén. 2. Hussam Abuissa, MD, Philip G. Jones, MS, Steven P. Marso, MD, James H. O Keefe, JR, MD Kansas City, Missouri. Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers for Prevention of Type 2 Diabetes. A Meta-Analysis of Randomized Clinical Trials. Journal of the American College of Cardiology Vol. 46, No., 3. M. Uehara, H. Kishikawa, S. Isami, K. Kisanuki, Y. Ohkubo, N. Miyamura, T. Miyata, T. Yano, M. Shichiri. Effect on insulin sensitivity of angiotensin converting enzyme inhibitors with or without a sulphydryl group:bradyk inin may improve insulin resistance in dogs and humans. Diabetologia (1994) 37: Klaus Rave1, Sabine Flesch, W. Nikolaus K uhn-velten, Beate C. Hompesch, Lutz Heinemann, Tim Heise. Enhancement of blood glucose lowering effect of a sulfonylurea when coadministered with an ACE inhibitor: results of a glucoseclamp study. Diabetes Metab Res Rev ; 21: Krishna Kumar K, Augasti KT and Vijayammal PL. Hypoglycaemic and antioxidant activity of Salacia oblonga Wall. Extract in Streptozotocin induced diabetic rats. Indian J Pharmacol 1999; 43(3): Gupta B, Jaju B P. Glucose homeostasis and dugs acting on CNS: Interactions with antidiabetic agents. Indian J Pharmacol 1994; 26: Herfindianal E J, Gourley D R. Text book of therapeutics. Drug and disease management. 7 th ed. Lippincott Williams and Wilkins;. 3
Basic statistics for experimental medical researchers
Basic statistics for experimental medical researchers Sample size calculations September 15th 2016 Christian Pipper Department of public health (IFSV) Faculty of Health and Medicinal Science (SUND) E-mail:
Læs mereapplies equally to HRT and tibolone this should be made clear by replacing HRT with HRT or tibolone in the tibolone SmPC.
Annex I English wording to be implemented SmPC The texts of the 3 rd revision of the Core SPC for HRT products, as published on the CMD(h) website, should be included in the SmPC. Where a statement in
Læs mereCell Physiol Biochem 2015;37: DOI: / Published online: September 11, 2015
www.karger.com/cpb 719 1421-9778/15/0372-0719$39.50/0 Qi Accepted: et al.: JMJD2A August Inhibition 06, 2015 Attenuates Neointimal Hyperplasia in Diabetic Rats Original Paper This is an Open Access article
Læs mereVina Nguyen HSSP July 13, 2008
Vina Nguyen HSSP July 13, 2008 1 What does it mean if sets A, B, C are a partition of set D? 2 How do you calculate P(A B) using the formula for conditional probability? 3 What is the difference between
Læs mereN Engl J Med 2011;365:518-26
N Engl J Med 2011;365:518-26 Introduction Pleural infection more than 65,000 patients/year in US and UK mortality: 10~20% 1/3 failed for drainage + antibiotics surgical hospital stay: 12~15 days cost:
Læs mereGeneralized Probit Model in Design of Dose Finding Experiments. Yuehui Wu Valerii V. Fedorov RSU, GlaxoSmithKline, US
Generalized Probit Model in Design of Dose Finding Experiments Yuehui Wu Valerii V. Fedorov RSU, GlaxoSmithKline, US Outline Motivation Generalized probit model Utility function Locally optimal designs
Læs mereStatistik for MPH: 7
Statistik for MPH: 7 3. november 2011 www.biostat.ku.dk/~pka/mph11 Attributable risk, bestemmelse af stikprøvestørrelse (Silva: 333-365, 381-383) Per Kragh Andersen 1 Fra den 6. uges statistikundervisning:
Læs mereGusset Plate Connections in Tension
Gusset Plate Connections in Tension Jakob Schmidt Olsen BSc Thesis Department of Civil Engineering 2014 DTU Civil Engineering June 2014 i Preface This project is a BSc project credited 20 ECTS points written
Læs mereProject Step 7. Behavioral modeling of a dual ported register set. 1/8/ L11 Project Step 5 Copyright Joanne DeGroat, ECE, OSU 1
Project Step 7 Behavioral modeling of a dual ported register set. Copyright 2006 - Joanne DeGroat, ECE, OSU 1 The register set Register set specifications 16 dual ported registers each with 16- bit words
Læs mereOn the complexity of drawing trees nicely: corrigendum
Acta Informatica 40, 603 607 (2004) Digital Object Identifier (DOI) 10.1007/s00236-004-0138-y On the complexity of drawing trees nicely: corrigendum Thorsten Akkerman, Christoph Buchheim, Michael Jünger,
Læs mereKvant Eksamen December 2010 3 timer med hjælpemidler. 1 Hvad er en continuous variable? Giv 2 illustrationer.
Kvant Eksamen December 2010 3 timer med hjælpemidler 1 Hvad er en continuous variable? Giv 2 illustrationer. What is a continuous variable? Give two illustrations. 2 Hvorfor kan man bedre drage konklusioner
Læs mereBilag. Resume. Side 1 af 12
Bilag Resume I denne opgave, lægges der fokus på unge og ensomhed gennem sociale medier. Vi har i denne opgave valgt at benytte Facebook som det sociale medie vi ligger fokus på, da det er det største
Læs mereVores mange brugere på musskema.dk er rigtig gode til at komme med kvalificerede ønsker og behov.
På dansk/in Danish: Aarhus d. 10. januar 2013/ the 10 th of January 2013 Kære alle Chefer i MUS-regi! Vores mange brugere på musskema.dk er rigtig gode til at komme med kvalificerede ønsker og behov. Og
Læs mereGeriatrisk selskab Ældre med hypertension og diabetes. Kent Lodberg Christensen Hjertemedicinsk afdeling B Århus Univ Hosp, Aarhus Sgh THG
Geriatrisk selskab Ældre med hypertension og diabetes Kent Lodberg Christensen Hjertemedicinsk afdeling B Århus Univ Hosp, Aarhus Sgh THG Metaanalyse af 39 studier med aktiv beh vs. placebo Død 10 %* CV-død
Læs mereUser Manual for LTC IGNOU
User Manual for LTC IGNOU 1 LTC (Leave Travel Concession) Navigation: Portal Launch HCM Application Self Service LTC Self Service 1. LTC Advance/Intimation Navigation: Launch HCM Application Self Service
Læs mereDiabetic Nephropathy
Diabetic Nephropathy Steno Diabetes Center The magnitude of the problem 2010 2030 Total number of people with diabetes (age 20-79) Prevalence of diabetes (age 20-79) 285 million 438 million 6.6 % 7.8 %
Læs mereX M Y. What is mediation? Mediation analysis an introduction. Definition
What is mediation? an introduction Ulla Hvidtfeldt Section of Social Medicine - Investigate underlying mechanisms of an association Opening the black box - Strengthen/support the main effect hypothesis
Læs mereMeasuring Evolution of Populations
Measuring Evolution of Populations 2007-2008 5 Agents of evolutionary change Mutation Gene Flow Non-random mating Genetic Drift Selection Populations & gene pools Concepts a population is a localized group
Læs mereLinear Programming ١ C H A P T E R 2
Linear Programming ١ C H A P T E R 2 Problem Formulation Problem formulation or modeling is the process of translating a verbal statement of a problem into a mathematical statement. The Guidelines of formulation
Læs mereAnvendelse af Lægemiddelstatistikregistret til forskning: Fra opstart af evidensbaseret behandling til compliance og lægemiddelsikkerhed
Anvendelse af Lægemiddelstatistikregistret til forskning: Fra opstart af evidensbaseret behandling til compliance og lægemiddelsikkerhed Gunnar H. Gislason overlæge, ph.d. Kardiologisk afdeling Gentofte
Læs mereStatistik for MPH: oktober Attributable risk, bestemmelse af stikprøvestørrelse (Silva: , )
Statistik for MPH: 7 29. oktober 2015 www.biostat.ku.dk/~pka/mph15 Attributable risk, bestemmelse af stikprøvestørrelse (Silva: 333-365, 381-383) Per Kragh Andersen 1 Fra den 6. uges statistikundervisning:
Læs mereEngelsk. Niveau C. De Merkantile Erhvervsuddannelser September 2005. Casebaseret eksamen. www.jysk.dk og www.jysk.com.
052430_EngelskC 08/09/05 13:29 Side 1 De Merkantile Erhvervsuddannelser September 2005 Side 1 af 4 sider Casebaseret eksamen Engelsk Niveau C www.jysk.dk og www.jysk.com Indhold: Opgave 1 Presentation
Læs mereEngelsk. Niveau D. De Merkantile Erhvervsuddannelser September Casebaseret eksamen. og
052431_EngelskD 08/09/05 13:29 Side 1 De Merkantile Erhvervsuddannelser September 2005 Side 1 af 4 sider Casebaseret eksamen Engelsk Niveau D www.jysk.dk og www.jysk.com Indhold: Opgave 1 Presentation
Læs mereFejlbeskeder i SMDB. Business Rules Fejlbesked Kommentar. Validate Business Rules. Request- ValidateRequestRegist ration (Rules :1)
Fejlbeskeder i SMDB Validate Business Rules Request- ValidateRequestRegist ration (Rules :1) Business Rules Fejlbesked Kommentar the municipality must have no more than one Kontaktforløb at a time Fejl
Læs mereATEX direktivet. Vedligeholdelse af ATEX certifikater mv. Steen Christensen stec@teknologisk.dk www.atexdirektivet.
ATEX direktivet Vedligeholdelse af ATEX certifikater mv. Steen Christensen stec@teknologisk.dk www.atexdirektivet.dk tlf: 7220 2693 Vedligeholdelse af Certifikater / tekniske dossier / overensstemmelseserklæringen.
Læs mereAfbestillingsforsikring
Afbestillingsforsikring Sygdomsafbestillingsforsikring ved akut sygdom, ulykke. Da afbestilling på grund af akut sygdom, ulykke m.m. ikke fritager deltagerne for betaling, kan det anbefales, at der tegnes
Læs mereEvaluating Germplasm for Resistance to Reniform Nematode. D. B. Weaver and K. S. Lawrence Auburn University
Evaluating Germplasm for Resistance to Reniform Nematode D. B. Weaver and K. S. Lawrence Auburn University Major objectives Evaluate all available accessions of G. hirsutum (TX list) for reaction to reniform
Læs mereSpecial VFR. - ved flyvning til mindre flyveplads uden tårnkontrol som ligger indenfor en kontrolzone
Special VFR - ved flyvning til mindre flyveplads uden tårnkontrol som ligger indenfor en kontrolzone SERA.5005 Visual flight rules (a) Except when operating as a special VFR flight, VFR flights shall be
Læs mereAktivering af Survey funktionalitet
Surveys i REDCap REDCap gør det muligt at eksponere ét eller flere instrumenter som et survey (spørgeskema) som derefter kan udfyldes direkte af patienten eller forsøgspersonen over internettet. Dette
Læs mereAgenda. The need to embrace our complex health care system and learning to do so. Christian von Plessen Contributors to healthcare services in Denmark
Agenda The need to embrace our complex health care system and learning to do so. Christian von Plessen Contributors to healthcare services in Denmark Colitis and Crohn s association Denmark. Charlotte
Læs mereOur Mission We have been in business for 19 years. We help people who have eye problems. Our custom tinted soft contact lenses change lives.
WE CHANGE LIVES Our Mission We have been in business for 19 years. We help people who have eye problems. Our custom tinted soft contact lenses change lives. Our Services Enhancement & Therapeutic Soft
Læs mereMeasuring the Impact of Bicycle Marketing Messages. Thomas Krag Mobility Advice Trafikdage i Aalborg, 27.08.2013
Measuring the Impact of Bicycle Marketing Messages Thomas Krag Mobility Advice Trafikdage i Aalborg, 27.08.2013 The challenge Compare The pilot pictures The choice The survey technique Only one picture
Læs merePortal Registration. Check Junk Mail for activation . 1 Click the hyperlink to take you back to the portal to confirm your registration
Portal Registration Step 1 Provide the necessary information to create your user. Note: First Name, Last Name and Email have to match exactly to your profile in the Membership system. Step 2 Click on the
Læs mereIndhold 1. INDLEDNING...4
Abstract This thesis has explored the hypothesis that emotional dysregulation may be involved in problems with non response and high dropout rates, which are characteristicofthecurrenttreatmentofposttraumatic,stressdisorder(ptsd).
Læs mereF o r t o l k n i n g e r a f m a n d a l a e r i G I M - t e r a p i
F o r t o l k n i n g e r a f m a n d a l a e r i G I M - t e r a p i - To fortolkningsmodeller undersøgt og sammenlignet ifm. et casestudium S i g r i d H a l l b e r g Institut for kommunikation Aalborg
Læs mereTrolling Master Bornholm 2013
Trolling Master Bornholm 2013 (English version further down) Tilmeldingen åbner om to uger Mandag den 3. december kl. 8.00 åbner tilmeldingen til Trolling Master Bornholm 2013. Vi har flere tilmeldinger
Læs mereSkriftlig Eksamen Kombinatorik, Sandsynlighed og Randomiserede Algoritmer (DM528)
Skriftlig Eksamen Kombinatorik, Sandsynlighed og Randomiserede Algoritmer (DM58) Institut for Matematik og Datalogi Syddansk Universitet, Odense Torsdag den 1. januar 01 kl. 9 13 Alle sædvanlige hjælpemidler
Læs mereCentral Statistical Agency.
Central Statistical Agency www.csa.gov.et 1 Outline Introduction Characteristics of Construction Aim of the Survey Methodology Result Conclusion 2 Introduction Meaning of Construction Construction may
Læs mereNOTIFICATION. - An expression of care
NOTIFICATION - An expression of care Professionals who work with children and young people have a special responsibility to ensure that children who show signs of failure to thrive get the wright help.
Læs mereRichter 2013 Presentation Mentor: Professor Evans Philosophy Department Taylor Henderson May 31, 2013
Richter 2013 Presentation Mentor: Professor Evans Philosophy Department Taylor Henderson May 31, 2013 OVERVIEW I m working with Professor Evans in the Philosophy Department on his own edition of W.E.B.
Læs mereBusiness Rules Fejlbesked Kommentar
Fejlbeskeder i SMDB Validate Business Request- ValidateRequestRegi stration ( :1) Business Fejlbesked Kommentar the municipality must have no more than one Kontaktforløb at a time Fejl 1: Anmodning En
Læs mereTo the reader: Information regarding this document
To the reader: Information regarding this document All text to be shown to respondents in this study is going to be in Danish. The Danish version of the text (the one, respondents are going to see) appears
Læs mereKey words: HSVE, Serological Diagnosis, ELISA
Key words: HSVE, Serological Diagnosis, ELISA Fig. 1 IgM and IgG antibody levels in acute phase CSF of patients with HSVE by age as determined by ELISA index at 1: 10 dilution of CSF age in years Fig.
Læs mereMedicinske komplikationer efter hofte- og knæalloplastik (THA and KA) med fokus på trombosekomplikationer. Alma B. Pedersen
Medicinske komplikationer efter hofte- og knæalloplastik (THA and KA) med fokus på trombosekomplikationer Alma B. Pedersen Outline Introduction to epidemiology of THA and KA Epidemiology of medical complications:
Læs mereTrolling Master Bornholm 2014
Trolling Master Bornholm 2014 (English version further down) Den ny havn i Tejn Havn Bornholms Regionskommune er gået i gang med at udvide Tejn Havn, og det er med til at gøre det muligt, at vi kan være
Læs mereDumped ammunition - an environmental problem for sediment management?
5th International SedNet Conference, 27th-29th May 2008, Oslo, Norway Dumped ammunition - an environmental problem for sediment management? Jens Laugesen, Det Norske Veritas Harald Bjørnstad, Forsvarsbygg
Læs mereThe use of instrumented gait analysis in interdisciplinary interventions for children with cerebral palsy
PhD thesis The use of instrumented gait analysis in interdisciplinary interventions for children with cerebral palsy Helle Mätzke Rasmussen Department of Clinical Research Faculty of Health Sciences University
Læs mereFejlbeskeder i Stofmisbrugsdatabasen (SMDB)
Fejlbeskeder i Stofmisbrugsdatabasen (SMDB) Oversigt over fejlbeskeder (efter fejlnummer) ved indberetning til SMDB via webløsning og via webservices (hvor der dog kan være yderligere typer fejlbeskeder).
Læs mereReexam questions in Statistics and Evidence-based medicine, august sem. Medis/Medicin, Modul 2.4.
Reexam questions in Statistics and Evidence-based medicine, august 2013 2. sem. Medis/Medicin, Modul 2.4. Statistics : ESSAY-TYPE QUESTION 1. Intelligence tests are constructed such that the average score
Læs mereAn expression of care Notification. Engelsk
An expression of care Notification Engelsk Kolding Kommune Senior- og Socialforvaltningen, Familierådgivningen Professionals who work with children and young have a special responsibility to ensure that
Læs mereThe X Factor. Målgruppe. Læringsmål. Introduktion til læreren klasse & ungdomsuddannelser Engelskundervisningen
The X Factor Målgruppe 7-10 klasse & ungdomsuddannelser Engelskundervisningen Læringsmål Eleven kan give sammenhængende fremstillinger på basis af indhentede informationer Eleven har viden om at søge og
Læs mereHealth surveys. Supervision (much more) from the patients perspective. Charlotte Hjort Head of dep., MD, ph.d., MPG
Health surveys Supervision (much more) from the patients perspective Charlotte Hjort Head of dep., MD, ph.d., MPG 8.10.2018 The story 2002 Act on surveys at all nursing homes (frequentbased surveys) 600-800
Læs mereDen nye Eurocode EC Geotenikerdagen Morten S. Rasmussen
Den nye Eurocode EC1997-1 Geotenikerdagen Morten S. Rasmussen UDFORDRINGER VED EC 1997-1 HVAD SKAL VI RUNDE - OPBYGNINGEN AF DE NYE EUROCODES - DE STØRSTE UDFORDRINGER - ER DER NOGET POSITIVT? 2 OPBYGNING
Læs mereTrolling Master Bornholm 2015
Trolling Master Bornholm 2015 (English version further down) Panorama billede fra starten den første dag i 2014 Michael Koldtoft fra Trolling Centrum har brugt lidt tid på at arbejde med billederne fra
Læs mereBiocide resistance in Salmonella Typhimurium
FACULTY OF HEALTH AND MEDICAL SCIENCES UNIVERSITY OF COPENHAGEN PhD thesis Mette Rørbæk Gantzhorn Biocide resistance in Salmonella Typhimurium Academic advisor: Line Elnif Thomsen This thesis has been
Læs mereSport for the elderly
Sport for the elderly - Teenagers of the future Play the Game 2013 Aarhus, 29 October 2013 Ditte Toft Danish Institute for Sports Studies +45 3266 1037 ditte.toft@idan.dk A growing group in the population
Læs mereResource types R 1 1, R 2 2,..., R m CPU cycles, memory space, files, I/O devices Each resource type R i has W i instances.
System Model Resource types R 1 1, R 2 2,..., R m CPU cycles, memory space, files, I/O devices Each resource type R i has W i instances. Each process utilizes a resource as follows: request use e.g., request
Læs merePARALLELIZATION OF ATTILA SIMULATOR WITH OPENMP MIGUEL ÁNGEL MARTÍNEZ DEL AMOR MINIPROJECT OF TDT24 NTNU
PARALLELIZATION OF ATTILA SIMULATOR WITH OPENMP MIGUEL ÁNGEL MARTÍNEZ DEL AMOR MINIPROJECT OF TDT24 NTNU OUTLINE INEFFICIENCY OF ATTILA WAYS TO PARALLELIZE LOW COMPATIBILITY IN THE COMPILATION A SOLUTION
Læs mereBias og confounding. Søren Kold, overlæge, ph.d., klinisk lektor Aalborg Universitetshospital
Bias og confounding Søren Kold, overlæge, ph.d., klinisk lektor Aalborg Universitetshospital Bias og confounding Kritisk litteraturlæsning Introduktion Øvelse Information 5 min. Gruppearbejde 20 min. Diskussion
Læs mereUnitel EDI MT940 June 2010. Based on: SWIFT Standards - Category 9 MT940 Customer Statement Message (January 2004)
Unitel EDI MT940 June 2010 Based on: SWIFT Standards - Category 9 MT940 Customer Statement Message (January 2004) Contents 1. Introduction...3 2. General...3 3. Description of the MT940 message...3 3.1.
Læs mereAnalyseinstitut for Forskning
Analyseinstitut for Forskning CIS3 The Danish Non-response Analysis Peter S. Mortensen Notat 2003/1 fra Analyseinstitut for Forskning The Danish Institute for Studies in Research and Research Policy Finlandsgade
Læs mereObservation Processes:
Observation Processes: Preparing for lesson observations, Observing lessons Providing formative feedback Gerry Davies Faculty of Education Preparing for Observation: Task 1 How can we help student-teachers
Læs mereCohort of HBV and HCV Patients
Cohort of HBV and HCV Patients Emanuel K. Manesis, MD Professor of Medicine In 2003 the Hellenic Center for Disease Prevention & Control (HCDPC) started a cohort study of chronic HBV, HDV and HCV infection
Læs merePrivat-, statslig- eller regional institution m.v. Andet Added Bekaempelsesudfoerende: string No Label: Bekæmpelsesudførende
Changes for Rottedatabasen Web Service The coming version of Rottedatabasen Web Service will have several changes some of them breaking for the exposed methods. These changes and the business logic behind
Læs mereHelga Lara Halldorsdottier Et klædestykke med udgangspunkt i ubehag/gene for kroppen
Helga Lara Halldorsdottier Et klædestykke med udgangspunkt i ubehag/gene for kroppen Helga Lara Halldorsdottier Et klædestykke med udgangspunkt i ubehag/gene for kroppen Lili Uyen Thuy Pham, Shopaholic
Læs mereMorbidity and Mortality
There is a need for biomarkers in patients with multiple medical diseases Chronic Acute Complications Morbidity and Mortality supar = soluble form of upar D1 D1 upar D1 D2 D3 D3 D2 D3 D2 Immune cells Endothelial
Læs mereÅrsagsteori. Kim Overvad Afdeling for Epidemiologi Institut for Folkesundhed Aarhus Universitet April 2011
Årsagsteori Kim Overvad Afdeling for Epidemiologi Institut for Folkesundhed Aarhus Universitet April 2011 Årsager The cause of a disease event is an event, condition or characteristic that preceeded the
Læs mereEr implementering af 3R = Dyrevelfærd?
Er implementering af 3R = Dyrevelfærd? Dorte Bratbo Sørensen Det sundhedsvidenskabelige fakultet Institut for Veterinær- og Husdyrvidenskab 3R 3R Replace Reduce Refine Udfordringerne 3R Replace Reduce
Læs mereBasic Design Flow. Logic Design Logic synthesis Logic optimization Technology mapping Physical design. Floorplanning Placement Fabrication
Basic Design Flow System design System/Architectural Design Instruction set for processor Hardware/software partition Memory, cache Logic design Logic Design Logic synthesis Logic optimization Technology
Læs mereDendrokronologisk Laboratorium
Dendrokronologisk Laboratorium NNU rapport 14, 2001 ROAGER KIRKE, TØNDER AMT Nationalmuseet og Den Antikvariske Samling i Ribe. Undersøgt af Orla Hylleberg Eriksen. NNU j.nr. A5712 Foto: P. Kristiansen,
Læs mereHIV and Drug Prevention in Estonian Prisons
HIV and Drug Prevention in Estonian Prisons Maret Miljan The Division of Social Rehabilitation The Estonian Ministry of Justice Prisons in Estonia (3676 prisoners): Tallinn Prison ( 571 convicted male
Læs mereTrolling Master Bornholm 2014
Trolling Master Bornholm 2014 (English version further down) Ny præmie Trolling Master Bornholm fylder 10 år næste gang. Det betyder, at vi har fundet på en ny og ganske anderledes præmie. Den fisker,
Læs mereNews from the barn. by Nikolaj Stidsen and Michael Frederiksen. midtjysk svinerådgivning - vi flytter viden
News from the barn. by Nikolaj Stidsen and Michael Frederiksen Disposition The feed intake influence on farrowingrate and littersize Do I use to much sow food Polt feeding compared to age Number of born
Læs mereStatistical information form the Danish EPC database - use for the building stock model in Denmark
Statistical information form the Danish EPC database - use for the building stock model in Denmark Kim B. Wittchen Danish Building Research Institute, SBi AALBORG UNIVERSITY Certification of buildings
Læs mereBookingmuligheder for professionelle brugere i Dansehallerne 2015-16
Bookingmuligheder for professionelle brugere i Dansehallerne 2015-16 Modtager man økonomisk støtte til et danseprojekt, har en premieredato og er professionel bruger af Dansehallerne har man mulighed for
Læs mereBedømmelse af klinisk retningslinje foretaget af Enhed for Sygeplejeforskning og Evidensbasering Titel (forfatter)
Bedømmelse af klinisk retningslinje foretaget af Enhed for Sygeplejeforskning og Evidensbasering Titel (forfatter) Link til retningslinjen Resumé Formål Fagmålgruppe Anbefalinger Patientmålgruppe Implementering
Læs mereDENCON ARBEJDSBORDE DENCON DESKS
DENCON ARBEJDSBORDE Mennesket i centrum betyder, at vi tager hensyn til kroppen og kroppens funktioner. Fordi vi ved, at det er vigtigt og sundt jævnligt at skifte stilling, når man arbejder. Bevægelse
Læs mereDIVAR VIGTIGT! / IMPORTANT! MÅL / DIMENSIONS. The DIVAR wall lamp comes standard. with 2.4 m braided cord and a plug in power supply (EU or UK).
DIVAR VIGTIGT! / IMPORTANT! VIGTIGT læs vores anvisninger før du bruger produktet. Har du problemer med den elektriske installation, skal du kontakte en elektriker. Sørg for at altid slukke for strømmen
Læs mereWander TDEV Measurements for Inexpensive Oscillator
Wander TDEV Measurements for Inexpensive Oscillator Lee Cosart Symmetricom Lcosart@symmetricom.com Geoffrey M. Garner SAMSUNG Electronics (Consultant) gmgarner@comcast.net IEEE 802.1 AVB TG 2009.11.02
Læs mereQuality indicators for clinical pharmacy services
Quality indicators for clinical pharmacy services Head of Quality and Improvement, Nordsjælland Hospital Dorthe Vilstrup Tomsen Assuring quality in clinical pharmacy services Following international, national
Læs mereDepartment of Public Health. Case-control design. Katrine Strandberg-Larsen Department of Public Health, Section of Social Medicine
Department of Public Health Case-control design Katrine Strandberg-Larsen Department of Public Health, Section of Social Medicine Case-control design Brief summary: Comparison of cases vs. controls with
Læs mereTidevandstabeller for danske farvande. Tide tables for Danish waters
devandstabeller for danske farvande de tables for anish waters 0 Indhold ontents - orklaring til tabeller Explanation of tables Havnefortegnelse ist of ports - Tabeller for høj- og lavvandstidspunkter
Læs mereLearnings from the implementation of Epic
Learnings from the implementation of Epic Appendix Picture from Region H (2016) A thesis report by: Oliver Metcalf-Rinaldo, oliv@itu.dk Stephan Mosko Jensen, smos@itu.dk Appendix - Table of content Appendix
Læs mereMicroRNA-150 Inhibits the Activation of Cardiac Fibroblasts by Regulating c-myb
Original Paper 2016 The Author(s). 2016 Published The Author(s) by S. Karger AG, Basel Published online: May May 17, 17, 2016 2016 Published by S. Karger AG, Basel 2103 1421-9778/16/0386-2103$39.50/0 Accepted:
Læs mereManuel behandling for patienter med hofteartrose
Manuel behandling for patienter med hofteartrose Muskel- og ledsygdomme er den vigtigste årsag til funktionsbegrænsning i Danmark En dansker mister i gennemsnit 7 år med god livskvalitet pga muskel- og
Læs mereDIVAR VIGTIGT! / IMPORTANT! MÅL / DIMENSIONS
DIVAR VIGTIGT! / IMPORTANT! VIGTIGT læs vores anvisninger før du bruger produktet. Har du problemer med den elektriske installation, skal du kontakte en elektriker. Sørg for at altid slukke for strømmen
Læs mereErektiv dysfunktion og ESWT
Erektiv dysfunktion og ESWT Lars Lund Professor, overlæge, dr.med. Urologisk Afdeling L Odense Universitetshospital Hvad er erektiv dysfunktion? ED er den manglende evne til at få eller beholde en erektion
Læs mereHvordan får vi bugt med det fedmefremmende samfund?
Hvordan får vi bugt med det fedmefremmende samfund? Forebyggelse af overvægt og fedme hos børn hvad ved vi fra kontrollerede randomiserede undersøgelser? Berit L Heitmann, Professor PhD Enheden for Epidemiologisk
Læs mereTrolling Master Bornholm 2012
Trolling Master Bornholm 1 (English version further down) Tak for denne gang Det var en fornøjelse især jo også fordi vejret var med os. Så heldig har vi aldrig været før. Vi skal evaluere 1, og I må meget
Læs mereSmall Autonomous Devices in civil Engineering. Uses and requirements. By Peter H. Møller Rambøll
Small Autonomous Devices in civil Engineering Uses and requirements By Peter H. Møller Rambøll BACKGROUND My Background 20+ years within evaluation of condition and renovation of concrete structures Last
Læs mereTilmelding sker via stads selvbetjening indenfor annonceret tilmeldingsperiode, som du kan se på Studieadministrationens hjemmeside
Research Seminar in Computer Science Om kurset Subject Activitytype Teaching language Registration Datalogi master course English Tilmelding sker via stads selvbetjening indenfor annonceret tilmeldingsperiode,
Læs mereDoodleBUGS (Hands-on)
DoodleBUGS (Hands-on) Simple example: Program: bino_ave_sim_doodle.odc A simulation example Generate a sample from F=(r1+r2)/2 where r1~bin(0.5,200) and r2~bin(0.25,100) Note that E(F)=(100+25)/2=62.5
Læs mereSustainable investments an investment in the future Søren Larsen, Head of SRI. 28. september 2016
Sustainable investments an investment in the future Søren Larsen, Head of SRI 28. september 2016 Den gode investering Veldrevne selskaber, der tager ansvar for deres omgivelser og udfordringer, er bedre
Læs mereAlfa-1-antitrysin mangel hos børn. Elisabeth Stenbøg, Afd.læge, PhD Børneafd. A, AUH
Alfa-1-antitrysin mangel hos børn Elisabeth Stenbøg, Afd.læge, PhD Børneafd. A, AUH Hvad er det? Alfa-1-antitrypsin Proteinstof Produceres i leveren Fungerer i lungerne Regulerer neutrofil elastase balancen
Læs mereExam questions in Statistics and evidence-based medicine, spring sem. Medis/Medicin, Modul 2.4.
Exam questions in Statistics and evidence-based medicine, spring 2012 2. sem. Medis/Medicin, Modul 2.4. Statistics : ESSAY-TYPE QUESTION 1. In order to estimate the effect of the drug Captopril on blood
Læs mereBILAG 8.1.B TIL VEDTÆGTER FOR EXHIBIT 8.1.B TO THE ARTICLES OF ASSOCIATION FOR
BILAG 8.1.B TIL VEDTÆGTER FOR ZEALAND PHARMA A/S EXHIBIT 8.1.B TO THE ARTICLES OF ASSOCIATION FOR ZEALAND PHARMA A/S INDHOLDSFORTEGNELSE/TABLE OF CONTENTS 1 FORMÅL... 3 1 PURPOSE... 3 2 TILDELING AF WARRANTS...
Læs mereTrolling Master Bornholm 2016 Nyhedsbrev nr. 5
Trolling Master Bornholm 2016 Nyhedsbrev nr. 5 English version further down Kim Finne med 11 kg laks Laksen blev fanget i denne uge øst for Bornholm ud for Nexø. Et andet eksempel er her to laks taget
Læs mereYNKB TEMA 6. Adventure Playgrounds Copenhagen 2003
YNKB TEMA 6 YNKB TEMA 6-2003 Baldersgade 70 st tv DK 2200 N tlf +45 35851037 fax +45 35851837 www.ynkb.dk ISSN 1602-2815 Adventure Playgrounds Copenhagen 2003 The idea for adventure playgrounds originated
Læs mereOSAS CPAP behandling Hvor meget er nok? Ole Hilberg Lungemedicinsk afdeling Århus Universitetshospital
OSAS CPAP behandling Hvor meget er nok? Ole Hilberg Lungemedicinsk afdeling Århus Universitetshospital Evolutionen Adherence - historie Hippokrates tid: Effekten af diverse miksturer bliver noteret! 1979:
Læs mereBrystkræftscreening og overdiagnostik hvordan forstår vi stigningen i incidens?
Brystkræftscreening og overdiagnostik hvordan forstår vi stigningen i incidens? Henrik Støvring stovring@ph.au.dk 1. December 2016 Institut for Folkesundhed, AU Institutseminar, Vingsted Screening forskningsområdet
Læs mere