Using SAS Macros to Simplify Preparation of SDTM Data, Annotated CRFs and Define.xml. PhUse 2009, Basel. Niels Both Principal Consultant S-Cubed
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1 Using SAS Macros to Simplify Preparation of SDTM Data, Annotated CRFs and Define.xml PhUse 2009, Basel Niels Both Principal Consultant S-Cubed
2 Presentation - Overview ectd SDTM Generation Overall Architecture SDTM Step 1: Mapping Define.xml SDTM Step 2: Generic Macros Annotated CRF Conclusion
3 Background - ectd The study data specification
4 ectd Study Data Data Tabulation Datasets -SDTM Annotated Case Report Form Case Report Tabulation, data definition specification Define.xml Analysis Datasets -ADaM Subject Profiles Data Listings
5 ectd Study Data Data Tabulation Datasets -SDTM Annotated Case Report Form Case Report Tabulation, data definition specification Define.xml Analysis Datasets -ADaM
6 ectd Study Data Data Tabulation Datasets -SDTM Annotated Case Report Form Case Report Tabulation, data definition specification Define.xml
7 Presentation - Overview ectd SDTM Generation Overall Architecture SDTM Step 1: Mapping Define.xml SDTM Step 2: Generic Macros Annotated CRF Conclusion
8 Overall Architecture Unannotated CRF Annotated CRF Source Data SAS Metadata Engine Pre SDTM SAS SDTM Macros SDTM Mapping Specifications Define.xm l
9 Create Define.xml SDTM Traditional SAS metadata (variable names, dataset names etc). Define.xml Mapping Specifications CRF Page numbers, comments regarding mappings and derivations
10 Annotate CRF with SAS Unannotated CRF (PDF) Annotated CRF (PDF) CRF page numbers Annotations (FDF ascii file) Mapping Specifications MORE INFORMATION: Using SAS to Speed up Annotating Case Report Forms in PDF Format prepared by Dirk Spruck and Monika Kawohl (PharmaSug 2004 paper CC02)
11 Presentation - Overview ectd SDTM Generation Overall Architecture SDTM Step 1: Mapping Define.xml SDTM Step 2: Generic Macros Annotated CRF Conclusion
12 SDTM Generation Step 1 Step 2 Source Data SAS Metadata Engine Pre SDTM SAS SDTM Macros SDTM Mapping Specifications
13 SDTM Generation Step 1 Use ETL tool ie SAS (Clinical) Data Integration Studio Use traditional SAS code Use spreadsheet with mappings entered to auto-generate the transforming SAS program
14 SDTM Generation Step 2 Macro name %Usubjid %Domain %Dtc %Dy %Seq %LongChars %SuppqualCo Macro name %Relrec %Studyid %Bl %Stc %Res %SDTMify %PhysicalTransform
15 SDTM Generation Macros (1/14) %Usubjid Creates the USUBJID variable (Unique subject ID) as a concatenation of SUBJID and Study ID
16 SDTM Generation Macros (2/14) %Domain Creates the variable DOMAIN for all Pre SDTM datasets
17 SDTM Generation Macros (3/14) %DTC Creates all --DTC variables in ISO8601 format based on date/time components stored as individual variables in Pre SDTM
18 SDTM Generation Macros (4/14) %Dy Creates all --DY variables for each --DTC variable based on the RFSTDTC variable in the DM domain. The algorithm used is: --DY = (date portion of --DTC) - (date portion of RFSTDTC) + 1 if --DTC is on or after RFSTDTC --DY = (date portion of --DTC) - (date portion of RFSTDTC) if --DTC precedes RFSTDTC
19 SDTM Generation Macros (5/14) %Seq Sorts datasets and assigns --SEQ variables as a unique sequence number within each USUBJID
20 SDTM Generation Macros (6/14) %LongChars Identifies text strings longer than 200 characters and splits them up into multiple variables
21 SDTM Generation Macros (7/14) %SuppqualCo Creates supplementary datasets from extra columns on Pre SDTM datasets Also creates CO datasets where relevant
22 AE (Pre SDTM) SDTM Generation Macros (7/14) STUDYID DOMAIN USUBJID AESEQ AETERM AESER SQ_AESOTHC SCUB01 AE TRAUMA Y Neck Injury SUPPAE STUDYID RDOMAIN USUBJID IDVAR IDVARVAL QNAM QLABEL QVAL SCUB01 AE 123 AESEQ 1 AESOTHC Desc of Other Event Neck Injury AE (SDTM) STUDYID DOMAIN USUBJID AESEQ AETERM AESER SCUB01 AE TRAUMA Y
23 SDTM Generation Macros (8/14) %Relrec Creates RELREC dataset describing relationships between records in Pre SDTM datasets
24 SDTM Generation Macros (8/14) Relrec example: CM number 11&12 is related to AE number 3 RELREC STUDYID RDOMAIN USUBJID IDVAR IDVARVAL RELTYPE RELID SCUB01 AE 123 AESEQ 3 AECM1 SCUB01 CM 123 CMSEQ 11 AECM1 SCUB01 CM 123 CMSEQ 12 AECM1
25 SDTM Generation Macros (8/14) Relrec example: AE number 3 is related to CM number 11&12 Pre SDTM CM dataset: STUDYID DOMAIN USUBJID CMSEQ RELREC_AE... SCUB01 CM AESPID=3... SCUB01 CM AESPID= The macro identifies the variables starting with RELREC-, then finds the associated records in the AE datasets, and based on that creates the 3 RELREC records
26 SDTM Generation Macros (9/14) %Studyid Creates the variable STUDYID with the relevant study ID based on what is assigned in the Pre SDTM DM domain
27 SDTM Generation Macros (10/14) %Bl Creates the --BL variables, based on a defined algorithm (for example, by flagging the last assessement prior to RFSTDTC as the baseline value) Note: The existence of this statistically derived variable in the SDTM model is under review by the CDISC teams and the variable is expected to disappear from the SDTM model at some stage. Until that happens it is suggested to use a crude method like the above to set it and to note in the define document that it will not in all cases match the advanced baseline flags in the ADaM datasets.
28 SDTM Generation Macros (11/14) %Stc Creates the various results variables in the finding domains, based on the Pre SDTM variables --ORRES and --ORESSU (original result and unit)
29 SDTM Generation Macros (12/14) %Res Checks if the value of --STRESC is in fact numeric. In that case it is transferred to --STRESN
30 SDTM Generation Macros (13/14) %SDTMify Assigns labels and exact formats to all the variables in the created datasets and sorts dataset records and columns according to agreed rules
31 SDTM Generation Macros (14/14) %PhysicalTransform Turns the created SAS datasets into SAS transport files
32 Presentation - Overview ectd SDTM Generation Overall Architecture SDTM Step 1: Mapping Define.xml SDTM Step 2: Generic Macros Annotated CRF Conclusion
33 SDTM Generation Step 1 Step 2 Source Data SAS Metadata Engine Pre SDTM SAS SDTM Macros SDTM Mapping Specifications
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