2/3. Study design RESULTS DISCUSSION. Ethical considerations. Analysis. Central

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2 Central Kordestani et al. (2016) such as polyurethane adhesive. Dressings used for high exuding wounds were changed every day, and those with medium or low exudate were changed every other day according to wound management protocols. A pre-instructed nurse was assigned to supervise the procedure out, recording the patient s wound grade, age, gender, and data regarding dressing changes. Ethical considerations Before being included in the study, eligible participants accepted to sign the informed consent. Each participant was allowed to withdraw from the study whenever he/she desired. All the treatment devices were provided for the participants free Analysis The picture manager software was used to compare the therapeutic effects of the bioactive dressings on DFUs before and after application. The followings were assessed at each dressing changes:wound size Wound grade Wound healing status Duration of healing Figure (1) illustrates study design. RESULTS A total of 30 patients were analyzed in this study. Table 1 (included as supplimentary data) illustrates wound condition and shows the results of using ChitoTech wound dressings. DISCUSSION extended healing procedure, infection, affecting general health amputation. In this study it was demonstrated that the use of advanced bioactive wound dressings would result in decreasing hospitalization, and in turn, reduced hospital costs. Furthermore, in many cases it avoided the need for use of various dressings and drugs. All of the wounds treated with advanced bioactive wound dressings healed faster and none of them developed infection. While advanced bioactive wound dressings are commonly used in many countries, some practitioners in a number of developing countries are still hesitant to stop using traditional methods of wound managements such as gauze. ChitoTech advanced bioactive wound dressings to treat diabetic foot ulcers. ChitoTech bioactive wound dressings have been used in Study design Figure 1 Flowchart of Study design. JSM Foot Ankle 1(1): 1004 (2016) 2/3

3 Central Kordestani et al. (2016) Iran in the last 12 years and the results are reproducible. It may be readily applied in hospitals or in home care. Li ewise, the methodology used in this study is easily replicable if used in national and international context, both in the private and public sectors, for hospitals, and home care. CONCLUSION Acceleration in the wound healing is the main outcomes of using advanced bioactive wound dressings. The indings of the present study exhibited that using advance bioactive wound dressings can improve the uality of life of patients and reduce the cost of health care. REFERENCES 1. Boulton AJ. The diabetic foot: from art to science. The 18 th Camillo Golgi lecture. Diabetologia. 2004; 47: Carrington AL, awdsley S, orley, incey J, Boulton AJ. Psychological status of diabetic people with or without lower limb disability. Diabetes Res Clin Pract. 1996; 32: Clayton W, Elcasy TA. A Review of the Pathophysiology, Classi ication and Treatment of Foot Ulcers in Diabetic Patients. Clin Diabetes. 2009; 27: Gupta S, oirala J, hardori R, hardori. Infections in Diabetes ellitus and yperglycemia. Infect Dis Clin orth Am. 2007; 21: adan SS, Pai DR. Charcot neuroarthropathy of the foot and an le. Orthop Surg. 2013; 5: Scimeca CL, Bharara, Fisher T, imbriel, Armstrong DG. ovel use of platelet-rich plasma to augment curative diabetic foot surgery. J Diabetes Sci Technol. 2010; 4: Illum L. Chitosan and its use as a pharmaceutical excipient. Pharm Res. 1998; 15: Ishihara, Ono, Sato, a anishi, Saito, ura, et al. Acceleration of wound contraction and healing with a photocrosslin able chitosan hydrogel. Wound Repair Regen. 2001; 9: Ishihara, a anishi, Ono, Sato, i uchi, Saito, et al. Photocrosslin able chitosan as a dressing for wound occlusion and accelerator in healing process. Biomaterials. 2002; 23: Ceren Alemdaroglu, elihagul Degim, evin Celebi, Fatih or, Serdar Oztur, Deniz Erdogan. An investigation on burn wound healing in rats with chitosan gel formulation containing epidermal growth factor. Burns. 2006; 32: azdanpanah L, asiri, Adarvishi S. Literature review on the management of diabetic foot ulcer. World J Diabetes. 2015; 6: ordestani S, Shahrezaee, Tahmasebi, a imahmodi, a i Ghasemali D, Abyaneh S. A randomized controlled trial on the effectiveness of an advanced wound dressing used in Iran. J Wound Care. 2008; 17: Cite this article Kordestani SS, NayebHabib F, Abyaneh MS (2016) The Role of Advanced Bioactive Wound Dressings in Treating Diabetic Foot Ulcers. JSM Foot Ankle 1(1): JSM Foot Ankle 1(1): 1004 (2016) 3/3

4 Table 1: Wound condition. Case number Mean of wound size- initial (cm 2 ) Picture Duration of healing Mean of wound size- final (cm 2 ) Picture

6 12 75 4 7 70 120 10 8 32.5 120 0 9 3 10 2.

5 (Granular (Necroti Tissue) c Tissue)

11200(Necrotic 20 96(Granular Tissue) Tissue) 12 10

6 11200(Necrotic 20 96(Granular Tissue) Tissue)

9 Mean ± ± ± ± (SD):

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