Søgeprotokol for Nationale Kliniske Retningslinjer

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1 Søgeprotokol for Nationale Kliniske Retningslinjer Projekttitel/aspekt NKR 46 for Behandling af Anorexia Nervosa (primærlitteratur) Fagkonsulent /projektleder Tine Pedersen og Mette Bentz / Marie Jakobsen Søgespecialist Karen Tølbøl Sigaard Senest opdateret Baggrund PICO 1: Bør døgnbehandling af patienter med anoreksi være af kortere varighed, således at patienterne overgår til intensiv behandling i ambulant regi efter påbegyndt vægtindhentning ved selvstændig spisning? PICO 2: Bør patienter med anoreksi tilbydes psykoterapeutisk behandling i gruppe eller individuel psykoterapeutisk behandling som førstevalgsbehandling? PICO 3: Bør man skifte behandlingsform/øge intensiteten af behandlingen af patienter med anoreksi, som efter 6-12 sessioner/1-3 måneder ikke har effekt af førstevalgsbehandlingen? PICO 4: Bør behandlingen af patienter med anoreksi fokusere på kernesymptomerne ved anoreksi? PICO 5: Bør behandlingen af patienter med anoreksi indeholde specifikke mål for vægtindhentning? PICO 6: Bør behandlingen af patienter med anoreksi stile mod, at voksne patienter opnår BMI over 20, og at børn og unge opnår en vægt over 25-percentilen på højde-vægtkurven? PICO 7: Bør børn og unge med anoreksi tilbydes familiebaseret behandling eller individuel behandling som førstevalgsbehandling? PICO 8: Bør voksne med anoreksi tilbydes en behandlingsform, som inddrager de pårørende/netværket aktivt i behandlingen? PICO 9: Bør patienter med anoreksi tilbydes måltidsstøtte som supplement til vanlig behandling i ambulant regi? PICO 10: Bør patienter med anoreksi tilbydes fysisk

2 aktivitet under vejledning i vægtøgningsfasen som supplement til vanlig behandling? Søgetermer Inklusions- og eksklusionskriterier Se søgestrategierne under de enkelte PICOs Sprog: Engelsk, dansk, norsk og svensk År: Sidste 10 år ( ) Publikationstyper: Primærlitteratur (RCT) Informationskilder DATABASE INTERFACE DATO FOR SØGNING Medline OVID EMBASE OVID CINAHL EBSCO PSYCINFO OVID Note Søgetermer og inklusions- og eksklusionskriterier er tilpasset de enkelte databaser. Dubletter er så vidt muligt frasorteret ved hjælp af RefWorks. De fundne referencer overføres til Covidence (referenceværktøj) Fuldtekster præsenteres i Covidence i pdf-format Søgestrategi for hver enkelt database præsenteres hvis muligt vises det eksplicit hvor mange referencer den enkelte søgestreng genererer Til PICO 5 og 8 er søgningen udvidet til også også at omfatte søgning efter observationelle studier Søgestrategi Indhold PICO PICO PICO PICO PICO PICO 5 observationelle studier PICO PICO PICO

3 PICO 8 observationelle studier PICO PICO PICO 1 Database(s): Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) 1946 to Present Søgt d Search Strategy: # Searches Results 1 anorexia nervosa/ eating disorder*.mp "Feeding and Eating Disorders of Childhood"/ (restrict* and eat*).mp "Feeding and Eating Disorders"/ ("eating and feeding disorder" or "eating and feeding disorders").mp. 9 7 appetite disorder*.mp Anorexia/ anorex*.mp or/ treatment delivery.ti,ab,kw treatment setting*.ti,ab,kw stepped care.ti,ab,kw multimodal.ti,ab,kw exp "Referral and Consultation"/ (referral* or referred or referring).ti,ab,kw hospital discharge.ti,ab,kw inpatient treatment.ti,ab,kw inpatient unit.ti,ab,kw exp Hospitalization/ (hospitaliz* or hospitalis*).ti,ab,kw residential care.ti,ab,kw Residential Treatment/ residential treatment.ti,ab,kw residential unit.ti,ab,kw Day Care, Medical/ 4847

4 27 day care.ti,ab,kw daycare.ti,ab,kw day unit.ti,ab,kw specialist treatment.ti,ab,kw specialized treatment.ti,ab,kw specialised treatment.ti,ab,kw treatment optimization.ti,ab,kw treatment optimisation.ti,ab,kw Inpatients/ (inpatient* or in patient*).ti,ab,kw or Outpatients/ (daypatient* or day patient* or outpatient* or out patient*).ti,ab,kw or and ((Weight or eating) adj5 restor*).ti,ab,kw (re-feed* or refeed*).ti,ab,kw (independen* adj5 eating).ti,ab,kw ((normaliz* or normalis*) adj5 (eating or behavior or behaviour or habit or pattern)).ti,ab,kw. 46 (sufficient adj5 (food intake or eating)).ti,ab,kw (Weight adj5 (normalization or normalisation)).ti,ab,kw length of stay.ti,ab,kw length of hospital stay.ti,ab,kw inpatient admission.ti,ab,kw (admission adj3 hospital).ti,ab,kw length of inpatient stay.ti,ab,kw hospital treatment.ti,ab,kw day clinic*.ti,ab,kw outpatient clinic*.ti,ab,kw clinical management.ti,ab,kw out patient clinic*.ti,ab,kw clinical support.ti,ab,kw day centre*.ti,ab,kw day center*.ti,ab,kw day treatment*.ti,ab,kw Residential.ti,ab,kw day hospital.ti,ab,kw or/11-34, and

5 66 limit 65 to (controlled clinical trial or randomized controlled trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or 68 or and or limit 72 to (yr="2014 -Current" and (danish or english or norwegian or swedish)) 51 Database(s): Embase 1974 to 2016 March 09 Søgt d Search Strategy: # Searches Results 1 eating disorder/ or anorexia nervosa/ eating disorder*.mp anorex*.mp ("eating and feeding disorder" or "eating and feeding disorders").mp feeding disorder/ anorexia/ appetite disorder/ appetite disorder*.mp (restrict* and eat*).mp or/ treatment delivery.ti,ab,kw treatment setting*.ti,ab,kw stepped care.ti,ab,kw multimodal.ti,ab,kw patient referral/ (referral* or referred or referring).ti,ab,kw hospital discharge/ hospital discharge.ti,ab,kw inpatient treatment.ti,ab,kw inpatient unit.ti,ab,kw hospitalization/ (hospitaliz* or hospitalis*).ti,ab,kw residential care/ day care/ day care.ti,ab,kw daycare.ti,ab,kw. 1381

6 27 day unit.ti,ab,kw specialist treatment.ti,ab,kw specialized treatment.ti,ab,kw specialised treatment.ti,ab,kw treatment optimization.ti,ab,kw treatment optimisation.ti,ab,kw exp hospital patient/ (inpatient* or in patient*).ti,ab,kw or outpatient/ (daypatient* or day patient* or outpatient* or out patient*).ti,ab,kw or and ((Weight or eating) adj5 restor*).ti,ab,kw (re-feed* or refeed*).ti,ab,kw (independen* adj5 eating).ti,ab,kw ((normaliz* or normalis*) adj5 (eating or behavior or behaviour or habit or pattern)).ti,ab,kw. 44 (sufficient adj5 (food intake or eating)).ti,ab,kw (Weight adj5 (normalization or normalisation)).ti,ab,kw "length of stay"/ length of stay.ti,ab,kw length of hospital stay.ti,ab,kw hospital admission/ inpatient admission.ti,ab,kw (admission adj3 hospital).ti,ab,kw length of inpatient stay.ti,ab,kw hospital treatment.ti,ab,kw day hospital/ day clinic*.ti,ab,kw outpatient department/ outpatient clinic*.ti,ab,kw clinical management.ti,ab,kw out patient clinic*.ti,ab,kw clinical support.ti,ab,kw day centre*.ti,ab,kw day center*.ti,ab,kw day treatment*.ti,ab,kw residential.ti,ab,kw day hospital.ti,ab,kw. 4507

7 66 or/11-32, and limit 67 to (randomized controlled trial or controlled clinical trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or 70 or and or limit 74 to ((danish or english or norwegian or swedish) and yr="2014 -Current") 126 Database(s): PsycINFO 1806 to March Week Søgt d Search Strategy: # Searches Results 1 eating disorders/ or anorexia nervosa/ eating disorder*.mp anorex*.mp feeding disorders/ ("eating and feeding disorder" or "eating and feeding disorders").mp appetite disorder*.mp (restrict* and eat*).mp or/ treatment setting*.mp treatment delivery.mp stepped care.mp multimodal.mp professional referral/ (referral* or referred or referring).mp. [mp=title, abstract, heading word, table of contents, key concepts, original title, tests & measures] exp Hospitalization/ partial hospitalization/ hospital discharge.mp inpatient treatment.mp inpatient unit.mp (hospitaliz* or hospitalis*).mp exp Residential Care Institutions/ day care centers/ day care.mp daycare.mp. 1210

8 25 day unit.mp specialist treatment.mp specialized treatment.mp specialised treatment.mp treatment optimization.mp treatment optimisation.mp hospitalized patients/ (inpatient* or in patient*).mp or outpatients/ (daypatient* or day patient* or outpatient* or out patient*).mp or and ((Weight or eating) adj5 restor*).mp (re-feed* or refeed*).mp (independen* adj5 eating).mp ((normaliz* or normalis*) adj5 (eating or behavior or behaviour or habit or pattern)).mp (sufficient adj5 (food intake or eating)).mp (Weight adj5 (normalization or normalisation)).mp length of stay.mp length of hospital stay.mp inpatient admission.mp (admission adj3 hospital).mp length of inpatient stay.mp hospital treatment.mp day clinic*.mp outpatient clinic*.mp clinical management.mp out patient clinic*.mp clinical support.mp day centre*.mp day center*.mp day treatment*.mp residential.mp day hospital.mp or/9-30, and (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,id (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) 41159

9 adj (blind* or mask*))).ti,ab,id or and limit 65 to ((danish or english or norwegian or swedish) and yr="2014 -Current") 37 CINAHL Søgt d # Query Limiters/Expanders Results S68 S63 AND S67 S67 S64 OR S65 OR S66 S66 S65 TX (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) N1 (blind* or mask*))) TX (((random* or control#ed or crossover or crossover or blind* or mask*) N3 (trial* or study or studies or analy*)) or rct) S64 PT Randomized Controlled Trial S63 S8 AND S62 S62 S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S37 OR S38 OR S39 OR S40 OR S41 OR S42 OR S43 OR S44 OR S45 OR S46 OR S47 OR S48 OR S49 OR S50 OR S51 OR S52 OR S53 OR S54 OR S55 OR S56 OR S57 OR S58 OR S59 OR S60 OR S61 S61 "day hospital" S60 residential S59 "day treatment*" S58 "day center*" Limiters - Published Date: ; Language: Danish, English, Norwegian, Swedish S57 "day centre*" , , ,476 30,367 1, , ,

10 S56 "clinical support" S55 "out patient clinic*" S54 "clinical management" S53 "outpatient clinic*" S52 (MH "Outpatient Service") S51 "day clinic*" S50 "hospital treatment" S49 "length of inpatient stay" S48 (admission N3 hospital) S47 "inpatient admission" S46 "length of hospital stay" S45 "length of stay" S44 (MH "Length of Stay") S43 (Weight N5 (normalization or normalisation)) S42 (sufficient N5 ("food intake" or eating)) S41 ((normaliz* or normalis*) N5 (eating or behavior or behaviour or habit or pattern)) S40 (independen* N5 eating) S39 ("re-feed*" or refeed*) S38 ((Weight or eating) N5 restor*) S37 S35 AND S ,349 3,545 3, , ,216 22,199 18, ,913 S36 S33 OR S34 53,556

11 S35 S31 OR S32 S34 (daypatient* OR "day patient*" OR outpatient* OR "out patient*") S33 (MH "Outpatients") S32 (inpatient* OR "in patient*") S31 (MH "Inpatients") S30 "treatment optimisation" S29 "treatment optimization" S28 "day care" S27 "specialised treatment" S26 "specialized treatment" S25 "specialist treatment" S24 "day unit" S23 daycare S22 (MH "Day Care") S21 (MH "Residential Facilities+") S20 (MH "Residential Care") S19 (hospitaliz* or hospitalis*) S18 (MH "Hospitalization+") OR (MH "Patient Discharge+") OR (MH "Patient Admission") S17 "inpatient unit" S16 "inpatient treatment" 866,583 53,556 33, ,583 59, , ,874 20,525 4,217 43,817 62,367 S15 "hospital discharge" 4,

12 S14 (referral* or referred or referring) S13 (MH "Referral and Consultation+") S12 "multimodal" S11 "stepped care" S10 "treatment setting*" S9 "treatment delivery" S8 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 S7 ("eating and feeding disorder" or "eating and feeding disorders") S6 appetite disorder* S5 (restrict* and eat*) S4 (MH "Feeding and Eating Disorders of Childhood") S3 eating disorder* S2 anorex* S1 (MH "Eating Disorders") OR (MH "Anorexia Nervosa") OR (MH "Anorexia") 45,710 18,754 1, , , ,145 4,726 7,979 I alt 265 referencer, heraf 182 unikke. PICO 2 Database(s): Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) 1946 to Present

13 Søgt d Search Strategy: # Searches Results 1 anorexia nervosa/ eating disorder*.mp anorex*.mp Anorexia/ ("eating and feeding disorder" or "eating and feeding disorders").mp. 9 6 appetite disorder*.mp (restrict* and eat*).mp "Feeding and Eating Disorders"/ "Feeding and Eating Disorders of Childhood"/ or/ exp Psychotherapy, Group/ (group adj3 therapy).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] (group adj3 psychotherapy).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] 14 group counselling.mp group counseling.mp group treatment.mp group setting.mp group based.mp or 12 or 13 or 14 or 15 or 16 or 17 or and (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,sh. (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj (blind* or mask*))).ti,ab,kw,sh exp controlled clinical trial/ or exp randomized controlled trial/ or/ and limit 20 to (controlled clinical trial or randomized controlled trial) or limit 27 to (yr="2005 -Current" and (danish or english or norwegian or swedish)) 121 Database(s): Embase 1974 to 2016 January 12 Søgt d Search Strategy: # Searches Results

14 1 eating disorder/ or anorexia nervosa/ eating disorder*.mp anorex*.mp (restrict* and eat*).mp appetite disorder*.mp appetite disorder/ anorexia/ feeding disorder/ ("eating and feeding disorder" or "eating and feeding disorders").mp or/ group therapy/ (group adj3 therapy).mp. [mp=title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] (group adj3 psychotherapy).mp. [mp=title, abstract, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] 14 group counselling.mp group counseling.mp group treatment.mp group setting.mp group based.mp or/ and (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,sh. (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj (blind* or mask*))).ti,ab,kw,sh exp controlled clinical trial/ or/ and limit 20 to (randomized controlled trial or controlled clinical trial) or limit 27 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 162 Database(s): PsycINFO 1806 to January Week Søgt d Search Strategy: # Searches Results

15 1 eating disorders/ or anorexia nervosa/ eating disorder*.mp anorex*.mp (restrict* and eat*).mp appetite disorder*.mp ("eating and feeding disorder" or "eating and feeding disorders").mp feeding disorders/ or/ exp Group Psychotherapy/ (group adj3 therapy).mp. [mp=title, abstract, heading word, table of contents, key concepts, original title, tests & measures] (group adj3 psychotherapy).mp. [mp=title, abstract, heading word, table of contents, key concepts, original title, tests & measures] group counseling.mp group counselling.mp group treatment.mp group setting.mp group based.mp or/ and (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,id,sh,md. (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj (blind* or mask*))).ti,ab,id,sh or/ and limit 18 to "2000 treatment outcome/clinical trial" or limit 24 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 58 CINAHL Søgt d # Query Limiters/Expanders Results S26 S24 OR S25 Limiters - Published Date: ; Language: Danish, English, Norwegian, Swedish S25 S13 AND S18 AND S S24 S13 AND S23 Limiters - Publication Type: Clinical Trial, Randomized Controlled Trial

16 S23 S4 OR S19 OR S20 OR S21 OR S22 10,705 S22 ("eating and feeding disorder" or "eating and feeding disorders") 2 S21 appetite disorder* 26 S20 (restrict* and eat*) 1,014 S19 (MH "Feeding and Eating Disorders of Childhood") 31 S18 S14 OR S15 OR S16 OR S17 176,137 S17 PT Randomized Controlled Trial 30,144 S16 (MH "Clinical Trials+") 132,852 S15 S14 S13 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) N1 (blind* or mask*))) (((random* or control#ed or crossover or cross-over or blind* or mask*) N3 (trial* or study or studies or analy*)) or rct) S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 45, ,832 41,240 S12 group based 7,923 S11 group setting 3,187 S10 group treatment 16,751 S9 group counseling 735 S8 group counselling 318 S7 (group N3 psychotherapy) 2,790 S6 (group N3 therapy) 4,126 S5 (MH "Psychotherapy, Group+") 12,395 S4 S1 OR S2 OR S3 10,077 S3 eating disorder* 7,092 S2 anorex* 4,698 S1 (MH "Eating Disorders") OR (MH "Anorexia Nervosa") OR (MH "Anorexia") 7,938 I alt 445 referencer, heraf 320 unikke. PICO 3 Database(s): Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) 1946 to Present

17 Søgt d Search Strategy: # Searches Results 1 anorexia nervosa/ eating disorder*.mp "Feeding and Eating Disorders of Childhood"/ (restrict* and eat*).mp "Feeding and Eating Disorders"/ ("eating and feeding disorder" or "eating and feeding disorders").mp. 9 7 appetite disorder*.mp Anorexia/ anorex*.mp or/ stepped care.mp multimodal.mp early respon*.mp ((treatment or treatments) adj5 (change* or intensif* or modif* or choice* or deliver* or evaluation or respons* or adapt*)).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] nonrespon*.mp non respon*.mp failure to respon*.mp poor respon*.mp late respon*.mp or/ and limit 21 to (controlled clinical trial or randomized controlled trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or 24 or and or limit 28 to (yr="2005 -Current" and (danish or english or norwegian or swedish)) 144 Database(s): Embase 1974 to 2016 February 26 Søgt d Search Strategy: # Searches Results

18 1 eating disorder/ or anorexia nervosa/ eating disorder*.mp anorex*.mp ("eating and feeding disorder" or "eating and feeding disorders").mp feeding disorder/ anorexia/ appetite disorder/ appetite disorder*.mp (restrict* and eat*).mp or/ stepped care.ti,ab,kw multimodal.ti,ab,kw early respon*.ti,ab,kw ((treatment or treatments) adj5 (change* or intensif* or modif* or choice* or deliver* or evaluation or respons* or adapt*)).ti,ab,kw nonrespon*.ti,ab,kw non respon*.ti,ab,kw failure to respon*.ti,ab,kw poor respon*.ti,ab,kw late respon*.ti,ab,kw or/ and limit 21 to (randomized controlled trial or controlled clinical trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or 24 or and or limit 28 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 743 Database(s): PsycINFO 1806 to February Week Søgt d Search Strategy: # Searches Results 1 eating disorders/ or anorexia nervosa/ eating disorder*.mp anorex*.mp feeding disorders/ ("eating and feeding disorder" or "eating and feeding disorders").mp appetite disorder*.mp. 37

19 7 (restrict* and eat*).mp or/ stepped care.mp multimodal treatment approach/ multimodal.mp early respon*.mp ((treatment or treatments) adj5 (change* or intensif* or modif* or choice* or deliver* or evaluation or respons* or adapt*)).mp nonrespon*.mp non respon*.mp failure to respon*.mp poor respon*.mp late respon*.mp or/ and (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,id. (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj (blind* or mask*))).ti,ab,id or and limit 24 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 195 CINAHL Søgt d # Query Limiters/Expanders Results S24 S19 AND S23 Limiters - Published Date: ; Language: Danish, English, Norwegian, Swedish S23 S20 OR S21 OR S22 821,794 S22 S21 TX (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) N1 (blind* or mask*))) TX (((random* or control#ed or crossover or cross-over or blind* or mask*) N3 (trial* or study or studies or analy*)) or rct) , ,652 S20 PT Randomized Controlled Trial 30,281 S19 S8 AND S S18 S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR 35,422

20 S17 S17 "late respon*" 70 S16 "poor respon*" 550 S15 "failure to respon*" 157 S14 "non respon*" 886 S13 nonrespon* 1,690 S12 ((treatment or treatments) N5 (change* or intensif* or modif* or choice* or deliver* or evaluation or respons* or adapt*)) 30,467 S11 "early respon*" 248 S10 multimodal 1,988 S9 "stepped care" 215 S8 S7 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 ("eating and feeding disorder" or "eating and feeding disorders") 10,775 2 S6 appetite disorder* 26 S5 (restrict* and eat*) 1,018 S4 (MH "Feeding and Eating Disorders of Childhood") 31 S3 eating disorder* 7,142 S2 anorex* 4,718 S1 (MH "Eating Disorders") OR (MH "Anorexia Nervosa") OR (MH "Anorexia") 7,971 I alt 1164 referencer, heraf 912 unikke. PICO 4 Database(s): Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) 1946 to Present Søgt d Search Strategy: # Searches Results 1 anorexia nervosa/ eating disorder*.mp "Feeding and Eating Disorders of Childhood"/ (restrict* and eat*).mp. 6269

21 5 "Feeding and Eating Disorders"/ ("eating and feeding disorder" or "eating and feeding disorders").mp. 9 7 appetite disorder*.mp Anorexia/ anorex*.mp or/ core symptom*.mp eating concern*.mp weight concern*.mp shape concern*.mp weight phobia.mp fat phobia.mp (fear and (eating or weight or fat or shape)).mp Body Image/ body image.mp body dissatisfaction.mp body checking.mp drive for thinness.mp compensatory behavio?rs.mp (overvaluation and (eat* or weight* or shape or body)).mp weight gain.mp (weight and (restitu* or recovery)).mp ("self-induced" and vomit*).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] 28 (misuse and (laxatives or diuretics)).mp over-exercis*.mp Fasting/ fasting.mp or/ Anorexia Nervosa/dh, dt, th [Diet Therapy, Drug Therapy, Therapy] "Feeding and Eating Disorders"/dh, dt, th [Diet Therapy, Drug Therapy, Therapy] Anorexia/dh, dt, th [Diet Therapy, Drug Therapy, Therapy] "Feeding and Eating Disorders of Childhood"/dh, dt, th [Diet Therapy, Drug Therapy, Therapy] 37 exp Therapeutics/ treatment.mp intervention.mp therapy.mp or/ and 32 and

22 43 limit 42 to (controlled clinical trial or randomized controlled trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or 45 or and or limit 49 to (yr="2005 -Current" and (danish or english or norwegian or swedish)) 390 Database(s): Embase 1974 to 2016 February 29 Søgt d Search Strategy: # Searches Results 1 eating disorder/ or anorexia nervosa/ eating disorder*.mp anorex*.mp ("eating and feeding disorder" or "eating and feeding disorders").mp feeding disorder/ anorexia/ appetite disorder/ appetite disorder*.mp (restrict* and eat*).mp or/ core symptom*.mp eating concern*.mp weight concern*.mp shape concern*.mp weight phobia.mp fat phobia.mp (fear and (eating or weight or fat or shape)).mp body image/ body image.mp body dissatisfaction.mp body checking.mp drive for thinness.mp compensatory behavio?rs.mp (overvaluation and (eat* or weight* or shape or body)).mp weight gain.ti,ab (weight and (restitu* or recovery)).mp

23 ("self-induced" and vomit*).mp. [mp=title, abstract, heading word, drug trade name, 27 original title, device manufacturer, drug manufacturer, device trade name, keyword] 28 (misuse and (laxatives or diuretics)).mp over-exercis*.mp *diet restriction/ fasting.mp or/ anorexia nervosa/dt, th [Drug Therapy, Therapy] eating disorder/dt, th [Drug Therapy, Therapy] feeding disorder/dt, th [Drug Therapy, Therapy] anorexia/dt, th [Drug Therapy, Therapy] appetite disorder/dt, th [Drug Therapy, Therapy] treatment.ti,ab intervention.ti,ab therapy.ti,ab exp *therapy/ or/ and 32 and limit 43 to (randomized controlled trial or controlled clinical trial) (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw ((single or double or triple) adj2 (blind* or mask*)).ti,ab,kw or 46 or and or limit 50 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 656 Database(s): PsycINFO 1806 to February Week Søgt d Search Strategy: # Searches Results 1 eating disorders/ or anorexia nervosa/ eating disorder*.mp anorex*.mp feeding disorders/ ("eating and feeding disorder" or "eating and feeding disorders").mp appetite disorder*.mp (restrict* and eat*).mp or/

24 9 core symptom*.mp eating concern*.mp weight concern*.mp shape concern*.mp weight phobia.mp fat phobia.mp (fear and (eating or weight or fat or shape)).mp body image/ or body image disturbances/ body image.mp body dissatisfaction.mp body checking.mp drive for thinness.mp compensatory behavio?rs.mp (overvaluation and (eat* or weight* or shape or body)).mp weight gain.mp (weight and (restitu* or recovery)).mp ("self-induced" and vomit*).mp. [mp=title, abstract, heading word, table of contents, key concepts, original title, tests & measures] 26 (misuse and (laxatives or diuretics)).mp over-exercis*.mp fasting.mp or/ exp treatment/ treatment.mp therapy.mp exp intervention/ intervention.mp or/ and 29 and (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,id. (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj (blind* or mask*))).ti,ab,id or and limit 40 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 182 CINAHL Søgt d

25 # Query Limiters/Expanders Results S45 S40 AND S44 Limiters - Published Date: ; Language: Danish, English, Norwegian, Swedish S44 S41 OR S42 OR S43 822,774 S43 S42 TX (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) N1 (blind* or mask*))) TX (((random* or control#ed or crossover or cross-over or blind* or mask*) N3 (trial* or study or studies or analy*)) or rct) , ,105 S41 PT Randomized Controlled Trial 30,318 S40 S8 AND S30 AND S39 1,119 S39 S31 OR S32 OR S33 OR S34 OR S35 OR S36 OR S37 OR S38 1,295,175 S38 "intervention" 111,634 S37 therapy 667,021 S36 (MH "Therapeutics+") 776,618 S35 "treatment" 388,901 S34 (MH "Feeding and Eating Disorders of Childhood/DH/DT/TH") 7 S33 (MH "Anorexia/DH/DT/TH") 257 S32 (MH "Anorexia Nervosa/DH/DT/TH") 742 S31 (MH "Eating Disorders/DH/DT/TH") 978 S30 S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 28,045 S29 (MH "Fasting") 2,067 S28 (MH "Body Image+") 6,446 S27 fasting 9,034 S26 "over-exercis*" 32 S25 (misuse and (laxatives or diuretics)) 20 S24 ("self-induced" and vomit*) 67 S23 (weight and (restitu* or recovery)) 2,750 S22 "weight gain" 8,592 S21 (overvaluation and (eat* or weight* or shape or body)) 14

26 S20 "compensatory behavio#rs" 64 S19 "drive for thinness" 181 S18 "body checking" 59 S17 "body dissatisfaction" 527 S16 "body image" 5,944 S15 (fear and (eating or weight or fat or shape)) 587 S14 "fat phobia" 19 S13 "weight phobia" 10 S12 "shape concern*" 112 S11 "weight concern*" 233 S10 "eating concern*" 72 S9 "core symptom*" 198 S8 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 10,783 S7 ("eating and feeding disorder" or "eating and feeding disorders") 2 S6 appetite disorder* 26 S5 (restrict* and eat*) 1,018 S4 (MH "Feeding and Eating Disorders of Childhood") 31 S3 eating disorder* 7,147 S2 anorex* 4,722 S1 (MH "Eating Disorders") OR (MH "Anorexia Nervosa") OR (MH "Anorexia") 7,977 I alt 1428 referencer, heraf 940 unikke. PICO 5 Database(s): Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R) 1946 to Present Søgt d Search Strategy: # Searches Results 1 anorexia nervosa/ eating disorder*.mp "Feeding and Eating Disorders of Childhood"/ (restrict* and eat*).mp. 6230

27 5 "Feeding and Eating Disorders"/ ("eating and feeding disorder" or "eating and feeding disorders").mp. 9 7 appetite disorder*.mp Anorexia/ anorex*.mp or/ weight regain.mp Weight Gain/ weight gain.mp (Weight and restitu*).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] 15 (weight adj3 recovery).mp (Bmi and gain).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] 17 (Bmi and restitu*).mp (Bmi and recovery).mp ("body mass index" adj10 gain).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] ("body mass index" and restitu*).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] ("body mass index" and recovery).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] (Bmi adj3 health*).mp (Bmi and ideal).mp (bmi adj5 normal).mp (bmi and target).mp ("body mass index" adj5 health*).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] ("body mass index" and ideal).mp ("body mass index" adj5 normal).mp ("body mass index" and target).mp (weight adj3 health*).mp (weight adj3 ideal).mp "normal weight".mp

28 33 (Weight adj5 target).mp *Body Mass Index/ exp *Body Weight/ or/ minimum weight gain.mp minimum weekly weight gain.mp mwwg.mp enforced weight restoration.mp assigned weight target*.mp treatment contract*.mp external incentive*.mp controlled motivation.mp extrinsic motivation.mp protocol.mp target*.mp mandat*.mp weekly.mp require*.mp focus*.mp or/ and 36 and or 38 or 39 or 40 or 41 or 42 or 43 or 44 or and or (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,sh. (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj (blind* or mask*))).ti,ab,kw,sh exp controlled clinical trial/ or exp randomized controlled trial/ or/ and limit 56 to (controlled clinical trial or randomized controlled trial) or limit 63 to (yr="2005 -Current" and (danish or english or norwegian or swedish)) 140 Database(s): Embase 1974 to 2016 January 27 Søgt d Search Strategy: # Searches Results

29 1 eating disorder/ or anorexia nervosa/ eating disorder*.mp anorex*.mp ("eating and feeding disorder" or "eating and feeding disorders").mp feeding disorder/ anorexia/ appetite disorder/ appetite disorder*.mp (restrict* and eat*).mp or/ weight regain.mp weight gain/ weight gain.mp (Weight and restitu*).mp (weight adj3 recovery).mp (Bmi and gain).mp (Bmi and restitu*).mp (Bmi and recovery).mp ("body mass index" adj10 gain).mp ("body mass index" and restitu*).mp ("body mass index" and recovery).mp (Bmi adj3 health*).mp (Bmi and ideal).mp (bmi adj5 normal).mp (bmi and target).mp ("body mass index" adj5 health*).mp ("body mass index" and ideal).mp ("body mass index" adj5 normal).mp ("body mass index" and target).mp (weight adj3 health*).mp (weight adj3 ideal).mp "normal weight".mp (Weight adj5 target).mp *body mass/ *body weight/ or *weight change/ or/ minimum weight gain.mp minimum weekly weight gain.mp mwwg.mp enforced weight restoration.mp. 0

30 41 assigned weight target*.mp treatment contract*.mp external incentive*.mp controlled motivation.mp extrinsic motivation.mp protocol.mp target*.mp mandat*.mp weekly.mp require*.mp focus*.mp or/ and 36 and or 38 or 39 or 40 or 41 or 42 or 43 or 44 or and or (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,sh. (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj (blind* or mask*))).ti,ab,kw,sh exp controlled clinical trial/ or/ and limit 56 to (randomized controlled trial or controlled clinical trial) or limit 63 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 366 Database(s): PsycINFO 1806 to January Week Søgt d Search Strategy: # Searches Results 1 eating disorders/ or anorexia nervosa/ eating disorder*.mp anorex*.mp feeding disorders/ ("eating and feeding disorder" or "eating and feeding disorders").mp appetite disorder*.mp (restrict* and eat*).mp or/ weight regain.mp. 215

31 10 weight gain/ weight gain.mp (Weight and restitu*).mp (weight adj5 recovery).mp (Bmi and gain).mp (Bmi and restitu*).mp (Bmi and recovery).mp ("body mass index" adj10 gain).mp ("body mass index" and restitu*).mp ("body mass index" and recovery).mp (Bmi adj5 health*).mp (Bmi and ideal).mp (bmi adj5 normal).mp (bmi and target).mp ("body mass index" adj5 health*).mp ("body mass index" and ideal).mp ("body mass index" adj5 normal).mp ("body mass index" and target).mp (weight adj5 health*).mp (weight adj5 ideal).mp "normal weight".mp (Weight adj5 target).mp *body mass index/ exp *body weight/ or exp *underweight/ or/ minimum weight gain.mp minimum weekly weight gain.mp mwwg.mp enforced weight restoration.mp assigned weight target*.mp treatment contract*.mp external incentive*.mp controlled motivation.mp extrinsic motivation.mp protocol.mp target*.mp mandat*.mp weekly.mp require*.mp focus*.mp

32 50 or/ and 34 and or 36 or 37 or 38 or 39 or 40 or 41 or 42 or and or (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,id,sh,md. (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj (blind* or mask*))).ti,ab,id,sh or and limit 54 to "2000 treatment outcome/clinical trial" or limit 60 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 118 CINAHL Søgt d # Query Limiters/Expanders Results S66 S64 OR S65 Limiters - Published Date: ; Language: Danish, English, Norwegian, Swedish 33 S65 S55 OR S57 Limiters - Publication Type: Clinical Trial, Randomized Controlled Trial S64 S58 AND S63 47 S63 S59 OR S60 OR S61 OR S62 176,445 S62 PT Randomized Controlled Trial 30,144 S61 (MH "Clinical Trials+") 133,010 S60 S59 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) N1 (blind* or mask*))) (((random* or control#ed or crossover or crossover or blind* or mask*) N3 (trial* or study or studies or analy*)) or rct) 21 46, ,102 S58 S55 OR S S57 S10 AND S56 4 S56 S38 OR S39 OR S40 OR S41 OR S42 OR S43 OR S44 OR S45 OR S46 OR S47 111

33 S55 S10 AND S37 AND S S54 S48 OR S49 OR S50 OR S51 OR S52 OR S53 333,637 S53 focus* 128,012 S52 require* 116,760 S51 weekly 10,469 S50 mandat* 13,524 S49 target* 61,644 S48 protocol 41,160 S47 "extrinsic motivation" 58 S46 "controlled motivation" 18 S45 "external incentive*" 16 S44 "treatment contract*" 19 S43 "assigned weight target*" 0 S42 "assigned weight targets" 0 S41 "enforced weight restoration" 0 S40 mwwg 0 S39 "minimum weekly weight gain" 0 S38 "minimum weight gain" 1 S37 S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S31 OR S32 OR S33 OR S34 OR S35 OR S36 21,802 S36 (MM "Body Weight") 3,035 S35 (MM "Body Mass Index") 4,087 S34 (Weight N10 target) 300 S33 "normal weight" 2,018 S32 (weight N10 ideal) 466 S31 (weight N3 health*) 2,105 S30 ("body mass index" and target) 827 S29 ("body mass index" N10 normal) 523 S28 ("body mass index" and ideal) 378 S27 ("body mass index" N5 health*) 693 S26 (bmi and target) 385 S25 (bmi N10 normal) 1,003 S24 (Bmi and ideal) 152 S23 (Bmi N5 health*) 612

34 S22 (Bmi N10 health*) 1,186 S21 ("body mass index" and recovery) 718 S20 ("body mass index" and restitu*) 1 S19 ("body mass index" N10 gain) 263 S18 (Bmi and recovery) 162 S17 (Bmi and restitu*) 0 S16 (Bmi AND gain) 1,044 S15 (weight N10 recovery) 229 S14 (Weight and restitu*) 12 S13 "weight gain" 8,539 S12 "weight regain" 164 S11 (MH "Weight Gain") OR (MH "Thinness") 6,284 S10 S4 OR S9 10,729 S9 S5 OR S6 OR S7 OR S8 1,070 S8 ("eating and feeding disorder" or "eating and feeding disorders") 2 S7 appetite disorder* 26 S6 (restrict* and eat*) 1,015 S5 (MH "Feeding and Eating Disorders of Childhood") 31 S4 S1 OR S2 OR S3 10,100 S3 eating disorder* 7,111 S2 anorex* 4,703 S1 (MH "Eating Disorders") OR (MH "Anorexia Nervosa") OR (MH "Anorexia") 7,945 I alt 657 referencer, heraf 529 unikke. PICO 5 observationelle studier Database(s): Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid Søgt d MEDLINE(R) 1946 to Present Search Strategy: # Searches Results

35 1 anorexia nervosa/ eating disorder*.mp "Feeding and Eating Disorders of Childhood"/ (restrict* and eat*).mp "Feeding and Eating Disorders"/ ("eating and feeding disorder" or "eating and feeding disorders").mp. 9 7 appetite disorder*.mp Anorexia/ anorex*.mp or/ weight regain.mp Weight Gain/ weight gain.mp (Weight and restitu*).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] 15 (weight adj3 recovery).mp (Bmi and gain).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] 17 (Bmi and restitu*).mp (Bmi and recovery).mp ("body mass index" adj10 gain).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] ("body mass index" and restitu*).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] ("body mass index" and recovery).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] (Bmi adj3 health*).mp (Bmi and ideal).mp (bmi adj5 normal).mp (bmi and target).mp ("body mass index" adj5 health*).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] ("body mass index" and ideal).mp ("body mass index" adj5 normal).mp ("body mass index" and target).mp. 2962

36 30 (weight adj3 health*).mp (weight adj3 ideal).mp "normal weight".mp (Weight adj5 target).mp *Body Mass Index/ exp *Body Weight/ or/ minimum weight gain.mp minimum weekly weight gain.mp mwwg.mp enforced weight restoration.mp assigned weight target*.mp treatment contract*.mp external incentive*.mp controlled motivation.mp extrinsic motivation.mp protocol.mp target*.mp mandat*.mp weekly.mp require*.mp focus*.mp or/ and 36 and or 38 or 39 or 40 or 41 or 42 or 43 or 44 or and or limit 56 to (comparative study or evaluation studies or multicenter study or observational study or twin study or validation studies) 58 exp Epidemiologic studies/ ((Epidemiologic or cohort* or perspective or prospective or longitud* or follow-up or follow up or followup or retro-spective or retrospective or case-control* or case control* or observational or cross-section* or cross section* or multi-cent* or multicent* or evaluation or comparative or intervention or provoca* or validation) adj3 (study or studies or trial* or analys*)).ti,ab,kw or and or limit 62 to (yr="2005 -Current" and (danish or english or norwegian or swedish)) 299 Database(s): Embase 1974 to 2016 February 04 Søgt d Search Strategy:

37 # Searches Results 1 eating disorder/ or anorexia nervosa/ eating disorder*.mp anorex*.mp ("eating and feeding disorder" or "eating and feeding disorders").mp feeding disorder/ anorexia/ appetite disorder/ appetite disorder*.mp (restrict* and eat*).mp or/ weight regain.mp weight gain/ weight gain.mp (Weight and restitu*).mp (weight adj3 recovery).mp (Bmi and gain).mp (Bmi and restitu*).mp (Bmi and recovery).mp ("body mass index" adj10 gain).mp ("body mass index" and restitu*).mp ("body mass index" and recovery).mp (Bmi adj3 health*).mp (Bmi and ideal).mp (bmi adj5 normal).mp (bmi and target).mp ("body mass index" adj5 health*).mp ("body mass index" and ideal).mp ("body mass index" adj5 normal).mp ("body mass index" and target).mp (weight adj3 health*).mp (weight adj3 ideal).mp "normal weight".mp (Weight adj5 target).mp *body mass/ *body weight/ or *weight change/ or/ minimum weight gain.mp minimum weekly weight gain.mp mwwg.mp enforced weight restoration.mp assigned weight target*.mp. 0