Søgeprotokol for Nationale Kliniske Retningslinjer

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1 Søgeprotokol for Nationale Kliniske Retningslinjer Projekttitel/aspekt NKR Demens Adfærdsforstyrrelser - Primærlitteratur Fagkonsulent Peter Roos / Annette Wittrup Enggaard /projektleder Søgespecialist Kirsten Birkefoss Senest opdateret Fokuserede spørgsmål PICO 1: Bør der laves en systematisk årsagsanalyse ved BPSD med henblik på individualiseret handleplan? PICO 2: Bør omsorg og behandling organiseres ud fra en personcentreret tilgang for at forebygge BPSD symptomer hos personer med demens? PICO 3: Bør personer med demens tilbydes superviseret konditionstræning for at forebygge BPSD? PICO 4: Bør der anvendes søvnhygiejne til at forebygge BPSD hos personer med demens og søvnforstyrrelser? PICO 5: Bør personer med demens tilbydes reminiscensterapi til behandling af BPSD? PICO 6: Bør nære pårørende til hjemmeboende personer med demens tilbydes psykoedukation for at forebygge BPSD symptomer? PICO 7: Bør personer med demens tilbydes musikterapi til behandling af BPSD? PICO 8: Bør personer med BPSD behandles med medicinske lægemidler mod demens? PICO 9: Bør personer med demens og forværring af BPSD behandles med SSRI præparater? PICO 10: Bør personer med demens og BPSD i form af aggressiv eller psykotisk adfærd behandles med 2. generations antipsykotika? Søgetermer Inklusions- og eksklusionskriterier Se søgestrategierne under de enkelte PICOs/PIROs Sprog: Engelsk, tysk, dansk, norsk og svensk År: Sidste 10 år, ( ) Population: Voksne fra og med 18 år Publikationstyper: RCT 1

2 Informationskilder DATABASE INTERFACE DATO FOR SØGNING Medline OVID EMBASE OVID The Cochrane library Internettet CINAHL EBSCO Pedro (PICO 1,2,3,4,5,6,7) Internettet OTSeeker (PICO 1,2,4,5,6,7) Internettet Note Søgetermer og inklusions- og eksklusionskriterier er tilpasset de enkelte databaser. Dubletter er så vidt muligt frasorteret ved hjælp af RefWorks. De fundne referencer overføres til Covidence (referenceværktøj) Fuldtekster præsenteres i Covidence i pdf-format Søgestrategi for hver enkelt database præsenteres hvis muligt vises det eksplicit hvor mange referencer den enkelte søgestreng genererer 2

3 SØGESTRATEGI Søgning efter systematiske reviews og metaanalyser PICO 1: Bør der laves en systematisk årsagsanalyse ved BPSD med henblik på individualiseret handleplan? Søgt Medline Database(s): Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE and Versions(R) 1946 to March Dementia/ exp Alzheimer Disease/ exp Aphasia, Primary Progressive/ exp Primary Progressive Nonfluent Aphasia/ 95 5 exp Dementia, Vascular/ exp Dementia, Multi-Infarct/ exp Frontotemporal Lobar Degeneration/ exp Frontotemporal Dementia/ exp Lewy Body Disease/ (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw,kf. 11 or/ exp Behavior/ exp Stress, Psychological/ exp Psychomotor Agitation/ exp Emotions/ Hallucinations/ exp Neurobehavioral Manifestations/ (BPSD or behavio* or agitat* or aggressi* or delusion* or hallucinat* or anxiety or anxious* or depressi* or sadness or mood disorder* or sleep disturbances or dysphoria or apath* or (aberrant adj1 (movement* or activit*)) or wandering or disinhibit* or confused or confusion or vocal*).ti,ab,kw,kf. 19 or/

4 20 ((functional or behavio* or psychological or systematic or method* or integrat* or holistic) adj6 (analys* or analyz* or assess* or observation* or map or mapping or evaluat*)).ti,ab,kw,kf. 21 (dementia care mapping or dcm).ti,ab,kw,kf (non-pharmacologic* adj5 (treatment* or therap* or intervention* or plan* or program* or 949 structur* or strateg* or protocol* or support*)).ti,kw,kf. 23 or/ and 19 and limit 24 to (randomized controlled trial or controlled clinical trial) (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,kf. 27 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab ((single or double or triple) adj2 (blind* or mask*)).ti,ab ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab,kw,kf. 30 or/ and or limit 32 to (yr=" " and (danish or english or german or norwegian or swedish)) limit 33 to (systematic reviews or review or letter or guideline or practice guideline) not Embase Database(s): Embase 1974 to 2018 March 20 1 Dementia/ exp Alzheimer Disease/ exp primary progressive aphasia/ exp Primary Progressive Nonfluent Aphasia/ exp frontotemporal dementia/ exp MultiInfarct Dementia/ exp Frontotemporal Lobar Degeneration/ exp pick presenile dementia/ exp diffuse lewy body disease/ mental deterioration/ exp presenile dementia/ exp senile dementia/ exp "mixed depression and dementia"/ 120 4

5 14 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,kw and (2016* or 2017* or 2018*).em or/1-13, exp Behavior/ exp behavior assessment/ restlessness/ exp Emotion/ exp Hallucination/ exp behavior disorder/ exp mental stress/ (BPSD or behavio* or agitat* or aggressi* or delusion* or hallucinat* or anxiety or anxious* or depressi* or sadness or mood disorder* or sleep disturbances or dysphoria or apath* or (aberrant adj1 (movement* or activit*)) or wandering or disinhibit* or confused or confusion or vocal* or mental stress).ti,ab,kw. 25 or/ ((functional or behavio* or psychological or systematic or method* or integrat* or holistic) adj6 (analys* or analyz* or assess* or observation* or map or mapping or evaluat*)).ti,ab,kw. 27 (dementia care mapping or dcm).ti,ab,kw or/ and 25 and limit 29 to (randomized controlled trial or controlled clinical trial) (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw. 32 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab ((single or double or triple) adj2 (blind* or mask*)).ti,ab ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab,kw. 35 or/ and or limit 37 to (yr=" " and (danish or english or german or norwegian or swedish)) limit 38 to ("systematic review" or review or letter or note) not PsycINFO Database(s): PsycINFO 1806 to March Week

6 1 exp Dementia/ exp Neurodegenerative Diseases/ (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,id. 4 or/ exp Behavior problems/ exp Emotional States/ exp Psychological stress/ exp Psychiatric Symptoms/ (BPSD or agitat* or aggressi* or delusion* or hallucinat* or anxiety or anxious* or depressi* or sadness or mood disorder* or sleep disturbances or dysphoria or apath* or (aberrant adj1 (movement* or activit*)) or wandering or disinhibit* or confused or confusion or vocal*).ti,ab,id. 10 or/ exp Behavioral assessment/ exp Behavior analysis/ ((functional or behavio* or psychological or systematic or method* or integrat* or holistic) adj6 (analys* or analyz* or assess* or observation* or map or mapping or evaluat*)).ti,ab,id. 14 (non-pharmacologic* adj5 (treatment* or therap* or intervention* or plan* or program* or 364 structur* or strateg* or protocol*)).ti,id. 15 or/ and 10 and (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,id. 18 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj2 (blind* or mask*))).ti,ab. 19 ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab,id. 20 or/ and limit 21 to (yr=" " and (danish or english or german or norwegian or swedish)) limit 22 to ("0830 systematic review" or "0800 literature review") not

7 Cinahl # Query Limiters/Expanders Results S17 S12 AND S16 Limiters - Published Date: ; Language: Danish, English, German, Norwegian, Swedish 157 S16 S13 OR S14 OR S15 153,918 S15 S14 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) N1 (blind* or mask*)) OR ((patient* or person* or participant* or population) N3 (random* or mask*)) (((random* or cluster-random* or crossover or cross-over or blind* or mask*) N4 (trial* or study or studies or analy*)) or rct) 74, ,680 S13 PT (Randomized Controlled Trial) 43,157 S12 S3 AND S7 AND S11 2,797 S11 S8 OR S9 OR S10 189,742 S10 (dementia care mapping or dcm) 490 S9 ((functional or behavio* or psychological or systematic or method* or integrat* or holistic) N6 (analys* or analyz* or assess* or observation* or map or mapping or evaluat*)) 189,350 S8 (MH "Geriatric Functional Assessment") 4,422 S7 S4 OR S5 OR S6 802,250 S6 S5 S4 (BPSD or behavio* or agitat* or aggressi* or delusion* or hallucinat* or anxiety or anxious* or depressi* or sadness or mood disorder* or sleep disturbances or dysphoria or apath* or (aberrant N1 (movement* or activit*)) or wandering or disinhibit* or confused or confusion or vocal*) (MH ("Behavior+" or "Psychomotor Agitation" or "Hallucinations")) (MH ("Emotions+" or "Stress, Psychological+" or Neurobehavioral Manifestations+)) 339, , ,699 7

8 S3 S1 OR S2 45,465 S2 TI (dementia* or alzheimer* or (Primary N3 Progressi* N3 aphasia) or (Frontotemporal N3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy N2 (body or bodies)) or (Parkinson* N4 dementia) or BPSD or PDD or FTD or DLB) 28,577 S1 (MH "Dementia+") 43,131 PEDRO Abstract and Title: Dementia* AND (functional analy* OR behavioral analy*) Method: Clinical trial Published since: fund OTSeeker Title/Abstract: Dementia* AND Title/Abstract: functional analy* OR behavioral analy* Method: Randomised Controlled Trial fund 8

9 PICO 2: Bør omsorg og behandling organiseres ud fra en personcentreret tilgang for at forebygge BPSD symptomer hos personer med demens? Søgt Medline Database(s): Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE and Versions(R) 1946 to March Dementia/ exp Alzheimer Disease/ exp Aphasia, Primary Progressive/ exp Primary Progressive Nonfluent Aphasia/ 95 5 exp Dementia, Vascular/ exp Dementia, Multi-Infarct/ exp Frontotemporal Lobar Degeneration/ exp Frontotemporal Dementia/ exp Lewy Body Disease/ (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw,kf. 11 or/ exp Patient-Centered Care/ exp Progressive Patient Care/ Holistic Nursing/ Holistic Health/ (personalis* or personaliz* or Person-centred or Person-centered or Person-oriented or Person-focused or Person-based or Person-tailored or Patient-centred or Patient-centered or Patient-oriented or Patient-focused or Patient-based or Patient-tailored or Personallycentred or Personally-centered or Personally-oriented or Personally-focused or Personallybased or Personally-tailor* or Client-centred or Client-centered or Client-oriented or Clientfocused or Client-based or Client-tailored or Individual-centred or Individual-centered or Individual-focused or Individual-oriented or Individual-based or Individual-tailored or individually-centred or individually-centered or Individually-focused or Individually-oriented or Individually-based or Individually-tailored or relationship-centred or relationshipcentered).ti,ab,kw,kf. 17 ((Person* or patient* or client* or individual*) adj3 (centred or center* or orient* or focus* or based or tailor*)).ti,ab,kw,kf. 18 ((Psychosocial or psycho-social or holistic or relation* or integrative or tailor* or Multimodal or multimodal or multi-component or multicomponent or multidisciplinary or multi- 9

10 disciplinary or interdisciplinary or inter-disciplinary or complimentary) adj6 (care or approach or Therap* or Treatment* or Intervention* or program* or plan* or rehabilitation or support* or method* or action* or management)).ti,ab,kw,kf. 19 (Dementia Care Mapping or DCM or VIPS or VPM or Marte Meo).ti,ab,kw or/ and limit 21 to (randomized controlled trial or controlled clinical trial) (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,kf. 24 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab ((single or double or triple) adj2 (blind* or mask*)).ti,ab ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab,kw,kf. 27 or/ and or limit 29 to (yr=" " and (danish or english or german or norwegian or swedish)) limit 30 to (systematic reviews or review or letter or guideline or practice guideline) not Embase Database(s): Embase 1974 to 2018 March 16 1 Dementia/ exp Alzheimer Disease/ exp primary progressive aphasia/ exp Primary Progressive Nonfluent Aphasia/ exp frontotemporal dementia/ exp Multiinfarct Dementia/ exp pick presenile dementia/ exp presenile dementia/ exp senile dementia/ mental deterioration/ exp diffuse lewy body disease/ exp "mixed depression and dementia"/ (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw and (2016* or 2017* or 2018*).em

11 15 or/1-12, exp Patient Preference/ exp Holistic Care/ (personalis* or personaliz* or Person-centred or Person-centered or Person-oriented or Person-focused or Person-based or Person-tailored or Patient-centred or Patient-centered or Patient-oriented or Patient-focused or Patient-based or Patient-tailored or Personallycentred or Personally-centered or Personally-oriented or Personally-focused or Personallybased or Personally-tailor* or Client-centred or Client-centered or Client-oriented or Clientfocused or Client-based or Client-tailored or Individual-centred or Individual-centered or Individual-focused or Individual-oriented or Individual-based or Individual-tailored or individually-centred or individually-centered or Individually-focused or Individually-oriented or Individually-based or Individually-tailored or relationship-centred or relationshipcentered).ti,ab,kw. 19 ((Person* or patient* or client* or individual*) adj3 (centred or center* or orient* or focus* or based or tailor*)).ti,ab,kw. 20 ((Psychosocial or psycho-social or holistic or individualized or relation* or integrative or tailor* or Multi-modal or multimodal or multi-component or multicomponent or multidisciplinary or multi-disciplinary or interdisciplinary or inter-disciplinary or complimentary) adj6 (care or approach or Therap* or Treatment* or Intervention* or program* or plan* or rehabilitation or support* or method* or action* or management)).ti,ab,kw. 21 (Dementia Care Mapping or DCM or VIPS or VPM or Marte Meo).ti,ab,kw or/ and limit 23 to randomized controlled trial (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw. 26 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab ((single or double or triple) adj2 (blind* or mask*)).ti,ab ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab,kw. 29 or/ and or limit 31 to (yr=" " and (danish or english or german or norwegian or swedish)) limit 32 to ("systematic review" or review or letter or note) not

12 PsycINFO Database(s): PsycINFO 1806 to March Week exp Dementia/ exp Neurodegenerative Diseases/ (dementia* or alzheimer* or Primary Progressive aphasia or Frontotemporal Degeneration or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,id. 4 or/ exp Client Centered Therapy/ Holistic Health/ (personalis* or personaliz* or Person-centred or Person-centered or Person-oriented or Person-focused or Person-based or Person-tailored or Patient-centred or Patient-centered or Patient-oriented or Patient-focused or Patient-based or Patient-tailored or Personallycentred or Personally-centered or Personally-oriented or Personally-focused or Personallybased or Personally-tailor* or Client-centred or Client-centered or Client-oriented or Clientfocused or Client-based or Client-tailored or Individual-centred or Individual-centered or Individual-focused or Individual-oriented or Individual-based or Individual-tailored or individually-centred or individually-centered or Individually-focused or Individually-oriented or Individually-based or Individually-tailored or relationship-centred or relationshipcentered).ti,ab,id. 8 ((Person* or patient* or client* or individual*) adj3 (centred or center* or orient* or focus* or based or tailor*)).ti,ab,id. 9 ((Psychosocial or psycho-social or holistic or individualized or relation* or integrative or tailor* or Multi-modal or multimodal or multi-component or multicomponent or multidisciplinary or multi-disciplinary or interdisciplinary or inter-disciplinary or complimentary) adj6 (care or approach or Therap* or Treatment* or Intervention* or program* or plan* or rehabilitation or support* or method* or action* or management)).ti,ab,id. 10 (Dementia Care Mapping or DCM or VIPS or VPM or Marte Meo).ti,ab,id or/ and (((random* or cluster-random* or crossover or cross-over or blind* or mask*) adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,id. 14 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj2 (blind* or mask*))).ti,ab. 15 ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab,id. 16 or/ and limit 17 to (yr=" " and (danish or english or german or norwegian or swedish))

13 19 limit 18 to ("0830 systematic review" or "0800 literature review" or 1200 meta analysis) not Cinahl # Query Limiters/Expanders Results S16 S15 not PT (Systematic Review or Review or Meta Analysis) 82 S15 s9 AND s13 Limiters - Published Date: ; Language: Danish, English, German, Norwegian, Swedish 103 S14 s9 AND s S13 S10 OR S11 OR S12 153,863 S12 S11 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) N1 (blind* or mask*)) OR ((patient* or person* or participant* or population) N3 (random* or mask*)) (((random* or cluster-random* or crossover or cross-over or blind* or mask*) N4 (trial* or study or studies or analy*)) or rct) 74, ,628 S10 PT (Randomized Controlled Trial) 43,157 S9 s3 AND s8 4,371 S8 S4 OR S5 OR S6 OR S7 165,321 S7 S6 ((holistic or relation* or integrative or tailor* or individualised or individualized or Multi-modal or multimodal or multi-component or multicomponent or multidisciplinary or multi-disciplinary or interdisciplinary or inter-disciplinary or complimentary) N6 (care or approach or Therap* or Treatment* or Intervention* or program* or plan* or rehabilitation or support* or method* or action* or management)) ((Person* or patient* or client* or individual*) N3 (centred or center* or orient* or focus* or based or tailor*)) 101,091 65,953 13

14 S5 S4 (personalis* or personaliz* or Person-centred or Personcentered or Person-oriented or Person-focused or Person-based or Person-tailored or Patient-centred or Patient-centered or Patient-oriented or Patient-focused or Patient-based or Patienttailored or Personally-centred or Personally-centered or Personally-oriented or Personally-focused or Personally-based or Personally-tailor* or Client-centred or Client-centered or Clientoriented or Client-focused or Client-based or Client-tailored or Individual-centred or Individual-centered or Individual-focused or Individual-oriented or Individual-based or Individual-tailored or individually-centred or individually-centered or Individuallyfocused or Individually-oriented or Individually-based or Individually-tailored or relationship-centred or relationshipcentered or (Dementia Care Mapping or DCM or VIPS or VPM or Marte Meo)) (MH "Patient Centered Care") OR (MH "Holistic Nursing") OR (MH "Holistic Health") OR (MH "Holistic Care") 34,268 24,340 S3 S1 OR S2 51,521 S2 (dementia* or alzheimer* or (Primary N3 Progressi* N3 aphasia) or (Frontotemporal N3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy N2 (body or bodies)) or (Parkinson* N4 dementia) or BPSD or PDD or FTD or DLB) 50,630 S1 (MH "Dementia+") 43,124 PEDRO Abstract and Title: Dementia* AND (person-centred* or person-centered or patient-centred or patientcentered or tailor* or personaliz*) Method: Clinical trial Published since: fund OTSeeker Title/Abstract: Dementia* AND Title/Abstract: (person-centred* or person-centered or patient-centred or patient-centered or tailor* or personaliz*) Method: Randomized Controlled Trial fund 14

15 PICO 3: Bør personer med demens tilbydes superviseret konditionstræning for at forebygge BPSD? Søgt Medline Database(s): Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE and Versions(R) 1946 to January 31, Dementia/ exp Alzheimer Disease/ exp Aphasia, Primary Progressive/ exp Primary Progressive Nonfluent Aphasia/ 94 5 exp Dementia, Vascular/ exp Dementia, Multi-Infarct/ exp Frontotemporal Lobar Degeneration/ exp Frontotemporal Dementia/ exp Lewy Body Disease/ (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw,kf. 11 or/ exp exercise/ exp exercise therapy/ exp Sports/ exp Physical Exertion/ exp Muscle strength/ exp Exercise Movement Techniques/ exp "Physical Education and Training"/ exp Hydrotherapy/ Weight-Bearing/ Tai Ji/ yoga/ Qigong/ (exercis* adj3 (instruct* or action or plan* or session* or program* or protocol*)).ti,ab,kw,kf. 25 (physical adj3 (activit* or exercise)).ti,ab,kw,kf ((muscl* or resistance or physical or endurance or strength* or balance or aquatic* or trunk) adj3 (train* or strength* or fitness or condition* or rehabilitation)).ti,ab,kw,kf. 15

16 27 (aerobic* or anaerobic* or movement therapy or watergym* or water gym* or aquagym or gym* or hydrotherap* or pilates or spinning).ti,ab,kw,kf. 28 (running or skiing or nordic walking or Jog* or zumba or Swim* or Bicycl* or cycling or walk* or rowing or pacing or paced or titreted or soccer or ball game* or (play* adj2 ball) or (weight* adj3 (lift* or train* or exercis*)) or (warm water adj4 (exercis* or train* or rehab))).ti,ab,kw,kf. 29 (yoga or tai ji or tai chi or qigong or qi-gong).ti,ab,kw or/ and limit 31 to (randomized controlled trial or controlled clinical trial) (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,kf. 34 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab ((single or double or triple) adj2 (blind* or mask*)).ti,ab ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab. 37 or/ and or limit 39 to (yr=" " and (danish or english or german or norwegian or swedish)) limit 40 to (systematic reviews or letter or guideline or practice guideline) not Embase Database(s): Embase 1974 to 2018 February 01 1 Dementia/ exp Alzheimer Disease/ exp primary progressive aphasia/ exp Primary Progressive Nonfluent Aphasia/ exp frontotemporal dementia/ exp pick presenile dementia/ exp presenile dementia/ exp senile dementia/ exp multiinfarct dementia/ mental deterioration/ exp diffuse lewy body disease/ exp "mixed depression and dementia"/

17 13 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw,kf and (2016* or 2017*).em or/1-12, exp exercise/ exp exercise therapy/ exp Sport/ exp Physical Exertion/ exp Muscle strength/ exp Exercise Movement Techniques/ exp "Physical Education and Training"/ exp Hydrotherapy/ Weight-Bearing/ Tai Chi/ yoga/ Qigong/ (exercis* adj3 (instruct* or action or plan* or session* or program* or protocol*)).ti,ab,kw,kf. 29 (physical adj3 (activit* or exercise)).ti,ab,kw,kf ((muscl* or resistance or physical or endurance or strength* or balance or aquatic* or trunk) adj3 (train* or strength* or fitness or condition* or rehabilitation)).ti,ab,kw,kf. 31 (aerobic* or anaerobic* or movement therapy or watergym* or water gym* or aquagym or gym* or hydrotherap* or pilates or spinning).ti,ab,kw,kf. 32 (running or skiing or nordic walking or Jog* or zumba or Swim* or Bicycl* or cycling or walk* or rowing or pacing or paced or titreted or soccer or ball game* or (play* adj2 ball) or (weight* adj3 (lift* or train* or exercis*)) or (warm water adj4 (exercis* or train* or rehab))).ti,ab,kw,kf. 33 (yoga or tai ji or tai chi or qigong or qi-gong).ti,ab,kw or/ and limit 35 to (randomized controlled trial or controlled clinical trial) (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,kf. 38 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab ((single or double or triple) adj2 (blind* or mask*)).ti,ab ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab. 41 or/ and or limit 43 to (yr=" " and (danish or english or german or norwegian or swedish))

18 45 limit 40 to ("systematic review" or letter or note) not Cinahl # Query Limiters/Expanders Results S16 s9 AND s14 Limiters - Published Date: ; Language: Danish, English, German, Norwegian, Swedish 115 S15 s9 AND s S14 S10 OR S11 OR S12 OR S13 160,241 S13 S12 S11 ((patient* or person* or participant* or population) N3 (random* or blind* or mask*)) (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) N1 (blind* or mask*)) (((random* or cluster-random* or control#ed or crossover or cross-over or blind* or mask*) N3 (trial* or study or studies or analy*)) or rct) 29,902 53, ,241 S10 PT Randomized Controlled Trial 42,405 S9 s3 AND s8 2,191 S8 S4 OR S5 OR S6 OR S7 199,984 S7 S6 (running or Skate* or skating or skiing or nordic walking or Jog* or zumba or Swim* or Bicycl* or cycling or walk* or powerwalk* or rowing or pacing or paced or titreted or soccer or ball game* or (play* N2 ball) or (weight* N3 (lift* or train* or exercis*))) (aerobic* or anaerobic* or movement therapy or watergym* or water gym* or aquagym or gym* or hydrotherap* or (warm water N4 (exercis* or train* or rehab)) or pilates or spinning or yoga or tai ji or tai chi or qigong or qi-gong) 69,671 22,870 18

19 S5 S4 ((exercis* N3 (instruct* or plan* or session* or program* or protocol*)) or (physical N3 (activit* or exercise)) or ((muscl* or resistance or physical or endurance or strength* or balance or aquatic* or trunk) N3 (train* or fit* or performance or condition* or rehabilitation))) MH ("Exercise+" OR "Exercise therapy+" OR "Sports+" OR "Physical Exertion+" OR "Muscle strength+" OR "Exercise Movement Techniques+" OR "Physical Education and Training+" OR "Hydrotherapy+" OR "Weight-Bearing" OR "Ta ji+" OR "Yoga+") 83, ,385 S3 S1 OR S2 51,045 S2 (dementia* or alzheimer* or (Primary N3 Progressi* N3 aphasia) or (Frontotemporal N3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy N2 (body or bodies)) or (Parkinson* N4 dementia) or BPSD or PDD or FTD or DLB) 50,160 S1 (MH "Dementia+") 42,604 Pedro Abstract and Title: Dementia* Therapy: Fitness training OR Strength training Method: Clinical trial Published since: fund 19

20 PICO 4: Bør der anvendes søvnhygiejne til at forebygge BPSD hos personer med demens og søvnforstyrrelser? Søgt Medline Database(s): Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE and Versions(R) 1946 to March Dementia/ exp Alzheimer Disease/ exp Aphasia, Primary Progressive/ exp Primary Progressive Nonfluent Aphasia/ 95 5 exp Dementia, Vascular/ exp Dementia, Multi-Infarct/ exp Frontotemporal Lobar Degeneration/ exp Frontotemporal Dementia/ exp Lewy Body Disease/ (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw,kf. 11 or/ Sleep/ exp Sleep deprivation/ exp Sleep Latency/ exp Sleep Wake Disorders/ exp Sleep Apnea Syndromes/ Wakefulness/ (sleep* or Insomnia* or dyssomnia* or somnambul* or wakeful* or somnolence).ti,ab,kw,kf ((Sleep* or circadian or biological clock) adj6 (disturb* or deprivation or disorder* or difficult* or disorder* or dysfunction* or disrupt* or abrupt* or reduc* or latency or problem* or apnea)).ti,ab,kw,kf. 20 or/ exp Sleep hygiene/ ((sleep* or circadian or biological clock or rest or nap or bed) adj10 (hygiene or pattern* or regulation or cycle* or syndrome or quality or treatment* or therap* or intervention* or plan* or program* or structur* or strateg* or protocol* or guid* or advic* or advis* or support* or diary or diaries)).ti,ab,kw,kf. 20

21 23 (bed*1 or bedroom* or bedding* or bedclothes or warming-pan* or linen or bedsheet* or warm* or pillow* or reclining or reclined or light*).ti,ab,kw,kf (actigraphy or music).ti,ab,kw or/ and 20 and limit 26 to (randomized controlled trial or controlled clinical trial) (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,kf (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab ((single or double or triple) adj2 (blind* or mask*)).ti,ab ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab,kw,kf or/ and or limit 34 to (yr=" " and (danish or english or german or norwegian or swedish)) limit 35 to (systematic reviews or letter or guideline or practice guideline) not Embase Database(s): Embase 1974 to 2018 March 21 1 Dementia/ exp Alzheimer Disease/ exp primary progressive aphasia/ exp Primary Progressive Nonfluent Aphasia/ exp frontotemporal dementia/ exp Multiinfarct Dementia/ exp Frontotemporal Lobar Degeneration/ exp pick presenile dementia/ exp diffuse lewy body disease/ mental deterioration/ exp presenile dementia/ exp senile dementia/ exp "mixed depression and dementia"/ (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw. 21

22 15 or/ Sleep/ exp Sleep deprivation/ exp Sleep Disorder/ exp sleep disordered breathing/ exp Wakefulness/ (sleep* or Insomnia* or dyssomnia* or somnambul* or wakeful* or somnolence).ti,ab,kw ((Sleep* or circadian or biological clock) adj6 (disturb* or deprivation or disorder* or difficult* or disorder* or dysfunction* or disrupt* or abrupt* or reduc* or latency or problem* or apnea)).ti,ab,kw or/ exp Sleep Hygiene/ ((sleep* or circadian or biological clock or rest or nap or bed) adj10 (hygiene* or pattern* or regulation or cycle* or syndrome or quality or treatment* or therap* or intervention* or plan* or program* or structur* or strateg* or protocol* or guid* or advic* or advis* or support* or routine* or diary or diaries)).ti,ab,kw. 26 (bed*1 or bedroom* or bedding* or bedclothes or warming-pan* or linen or bedsheet* or warm* or pillow* or (((reclining or reclined) adj3 wheelchair*) or bed*) or coffee or coffein* or tea or teine or music or actigraphy or light*).ti,ab,kw or/ and 23 and limit 28 to (randomized controlled trial or controlled clinical trial) (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab ((single or double or triple) adj2 (blind* or mask*)).ti,ab ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab,kw or/ and or limit 36 to (yr=" " and (danish or english or german or norwegian or swedish)) limit 37 to ("systematic review" or review or letter or note) not

23 PsycINFO Database(s): PsycINFO 1806 to March Week exp Dementia/ exp Neurodegenerative Diseases/ (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,id or/ Sleep/ napping/ exp Sleep deprivation/ exp Sleep Disorders/ exp Sleep Apnea/ Sleep Wake Cycle/ Wakefulness/ (sleep* or Insomnia* or dyssomnia* or somnambul* or wakeful* or somnolence).ti,ab,id ((Sleep* or circadian or biological clock) adj6 (disturb* or deprivation or disorder* or difficult* or disorder* or dysfunction* or disrupt* or abrupt* or reduc* or latency or problem* or apnea)).ti,ab,id or/ exp Sleep treatment/ exp Sleep Apnea/ exp Actigraphy/ ((sleep* or circadian or biological clock or rest or nap or bed) adj10 (hygiene or pattern* or regulation or cycle* or syndrome or quality or treatment* or therap* or intervention* or plan* or program* or structur* or strateg* or protocol* or guid* or advic* or advis* or support* or routine* or diary or diaries)).ti,ab,id. 19 (bed*1 or bedroom* or bedding* or bedclothes or warming-pan* or linen or bedsheet* or warm* or pillow* or (((reclining or reclined) adj3 wheelchair*) or bed*) or coffee or coffein* or tea or teine or music or actigraphy or light*).ti,ab,id. 20 or/ and 14 and (((random* or cluster-random* or crossover or cross-over or blind* or mask*) adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,id. 23 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj (blind* or mask*))).ti,ab. 24 ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab,id. 25 or/ and

24 27 limit 26 to (yr=" " and (danish or english or german or norwegian or swedish)) limit 27 to ("0830 systematic review" or "0800 literature review" or 1200 meta analysis) not Cinahl # Query Limiters/Expanders Results S17 S12 AND S16 Limiters - Published Date: ; Language: Danish, English, German, Norwegian, Swedish 21 S16 S13 OR S14 OR S15 161,809 S15 S14 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) N1 (blind* or mask*)) OR ((patient* or person* or participant* or population) N3 (random* or mask*)) (((random* or cluster-random* or control#ed or crossover or cross-over or blind* or mask*) N3 (trial* or study or studies or analy*)) or rct) 74, ,376 S13 PT Randomized Controlled Trial 43,321 S12 S3 AND S7 AND S S11 S8 OR S9 OR S10 99,398 S10 S9 (bed* or warming-pan* or linen or warm* or pillow* or (((reclining or reclined) N3 wheelchair*) or bed*) or coffee or coffein* or tea or teine or actigraphy or music or light*) ((sleep* or circadian or biological clock or rest or nap or bed) N10 (hygiene or pattern* or regulation or cycle* or syndrome or quality or treatment* or therap* or intervention* or plan* or program* or structur* or strateg* or protocol* or guid* or advic* or advis* or support* or routine* or diary or diaries)) 83,770 20,467 S8 (MH "Sleep hygiene+") 71 S7 S4 OR S5 OR S6 38,331 24

25 S6 S5 S4 ((Sleep* or circadian or biological clock) N6 (disturb* or deprivation or disorder* or difficult* or disorder* or dysfunction* or disrupt* or abrupt* or reduc* or latency or problem* or apnea)) (sleep* or Insomnia* or dyssomnia* or somnambul* or wakeful* or somnolence) (MH "Sleep") or (MH "Sleep disorders+") or (MH "Sleep deprivation+") 20,765 37,274 25,576 S3 S1 OR S2 51,584 S2 (dementia* or alzheimer* or (Primary N3 Progressi* N3 aphasia) or (Frontotemporal N3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy N2 (body or bodies)) or (Parkinson* N4 dementia) or BPSD or PDD or FTD or DLB) 50,693 S1 (MH "Dementia+") 43,200 PEDRO Abstract and Title: Dementia* AND sleep* Method: Clinical trial Published since: fund OTSeeker Title/Abstract: Dementia* AND Title/Abstract: Sleep* Method: Randomised Controlled Trial 4 fund 25

26 PICO 5: Bør personer med demens tilbydes reminiscensterapi til behandling af BPSD? Søgt Medline Database(s): Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE and Versions(R) 1946 to January 31, Dementia/ exp Alzheimer Disease/ exp Aphasia, Primary Progressive/ exp Primary Progressive Nonfluent Aphasia/ 94 5 exp Dementia, Vascular/ exp Dementia, Multi-Infarct/ exp Frontotemporal Lobar Degeneration/ exp Frontotemporal Dementia/ exp Lewy Body Disease/ (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw,kf. 11 or/ Mental Recall/ exp Memory/ ((reminisce* or memory or memories or memoriz* or recall* or recognition or recollect* or rememb* or souvenir* or keepsake* or ((bring* or brought) adj2 mind) or commemorate*) adj6 (stimulat* or care or approach or Therap* or Treat* or Intervention* or program* or plan* or rehabilitation or method* or activit* or exercise* or training)).ti,ab,kw,kf. 15 or/ and limit 16 to (randomized controlled trial or controlled clinical trial) (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,kf. 19 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw,kf ((single or double or triple) adj2 (blind* or mask*)).ti,ab ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab or/ and or limit 24 to (yr=" " and (danish or english or german or norwegian or swedish))

27 Embase Database(s): Embase 1974 to 2018 February 05 1 Dementia/ exp Alzheimer Disease/ exp primary progressive aphasia/ exp Primary Progressive Nonfluent Aphasia/ exp frontotemporal dementia/ exp pick presenile dementia/ exp presenile dementia/ exp senile dementia/ exp multiinfarct dementia/ mental deterioration/ exp diffuse lewy body disease/ exp "mixed depression and dementia"/ (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw,kf and (2016* or 2017* or 2018*).em or/1-12, exp memory/ ((reminisce* or memory or memories or memoriz* or recall* or recognition or recollect* or rememb* or souvenir* or keepsake* or ((bring* or brought) adj2 mind) or commemorate*) adj6 (stimulat* or care or approach or Therap* or Treat* or Intervention* or program* or plan* or rehabilitation or method* or activit* or exercise* or training)).ti,ab,kw,kf. 18 or/ and limit 19 to (randomized controlled trial or controlled clinical trial) (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,kf. 22 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw,kf ((single or double or triple) adj2 (blind* or mask*)).ti,ab ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab or/ and or limit 27 to (yr=" " and (danish or english or german or norwegian or swedish))

28 29 limit 28 to ("systematic review" or letter or note) not PsycINFO Database(s): PsycINFO 1806 to January Week exp Dementia/ exp Neurodegenerative Diseases/ (dementia* or alzheimer* or Primary Progressive aphasia or Frontotemporal Degeneration or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,id. 4 or/ exp Memory/ ((reminisce* or memory or memories or memoriz* or recall* or recognition or recollect* or rememb* or souvenir* or keepsake* or ((bring* or brought) adj2 mind) or commemorate*) adj6 (stimulat* or care or approach or Therap* or Treat* or Intervention* or program* or plan* or rehabilitation or method* or activit* or exercise* or training)).ti,ab,id. 7 or/ and (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or studies or analy*)) or rct).ti,ab,id. 10 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,id ((single or double or triple) adj2 (blind* or mask*)).ti,ab ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab or/ and limit 14 to (yr=" " and (danish or english or german or norwegian or swedish)) 93 Cinahl # Query Limiters/Expanders Results S13 s7 AND s11 Limiters - Published Date: ; Language: Danish, English, German, 46 28

29 Norwegian, Swedish S12 s7 AND s S11 S8 OR S9 OR S10 163,301 S10 S9 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) N1 (blind* or mask*)) OR ((patient* or person* or participant* or population) N3 (random* or blind* or mask*))) (((random* or cluster-random* or control#ed or crossover or cross-over or blind* or mask*) N5 (trial* or study or studies or analy*)) or rct) 74, ,053 S8 PT (Randomized Controlled Trial OR Controlled Clinical Trial) 42,405 S7 s3 AND s6 2,944 S6 S4 OR S5 25,296 S5 S4 ((reminisce* or memory or memories or memoriz* or recall* or recognition or recollect* or rememb* or souvenir* or keepsake* or ((bring* or brought) N2 mind) or commemorate*) N6 (stimulat* or care or approach or Therap* or Treat* or Intervention* or program* or plan* or rehabilitation or method* or activit* or exercise* or training)) (MH "Memory+") OR (MH "Memory Training (Iowa NIC)") OR (MH "Reminiscence Therapy") OR (MH "Reminiscence Therapy (Iowa NIC)") OR (MH "Life History Review") 11,720 15,911 S3 S1 OR S2 51,063 S2 (dementia* or alzheimer* or (Primary N3 Progressi* N3 aphasia) or (Frontotemporal N3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy N2 (body or bodies)) or (Parkinson* N4 dementia) or BPSD or PDD or FTD or DLB) 50,178 S1 (MH "Dementia+") 42,606 29

30 PEDRO Abstract and Title: Dementia* AND (Reminiscence therapy OR Memory therapy) Method: Clinical trial Published since: fund OT Seeker Title/Abstract: Dementia* AND Title/Abstract: Memory OR Reminiscence Method: Clinical trial fund 30

31 PICO 6: Bør nære pårørende til hjemmeboende personer med demens tilbydes psykoedukation for at forebygge BPSD symptomer? Søgt Medline Database(s): Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE and Versions(R) 1946 to January 31, Dementia/ exp Alzheimer Disease/ exp Aphasia, Primary Progressive/ exp Primary Progressive Nonfluent Aphasia/ 94 5 exp Dementia, Vascular/ exp Dementia, Multi-Infarct/ exp Frontotemporal Lobar Degeneration/ exp Frontotemporal Dementia/ exp Lewy Body Disease/ (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw,kf. 11 or/ exp Family/ exp Caregivers/ (Caregiver* or care giver* or carer* or Famil* or Couple* or Marital or spouse* or spousal or wife or wives or husband* or partner* or cohabitant* or "next of kin").ti,kw,kf. 15 or/ exp Patient Education as Topic/ exp Health Education/ (psycho-educat* or psychoeducat* or educat* or teach* or learn* or skill* or knowledg* or lesson* or instruct* or information or structur* or action or plan* or coping or session* or program* or strateg* or protocol* or interview* or Councel* or counsel* or Course* or Coach* or guid* or advic* or advis* or consultat* or mentor* or support*).ti,ab,kw,kf. 19 (Telephone or phone* or sms or video* orinternet* or internet-based or web-based or web based or computer* or computer-based or computer-assisted or PC or PC-based or pc-assisted or smartphone* or ipad* or tablet* or * or communicat* or telecommunication*).ti,ab,kw,kf. 20 or/ and 15 and

32 22 limit 21 to (randomized controlled trial or controlled clinical trial) (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,kf. 24 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab ((single or double or triple) adj2 (blind* or mask*)).ti,ab ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab,kw,kf. 27 or/ and or limit 29 to (yr=" " and (danish or english or german or norwegian or swedish)) limit 30 to (systematic reviews or letter or guideline or practice guideline) not Embase Database(s): Embase 1974 to 2018 February 05 1 Dementia/ exp Alzheimer Disease/ exp primary progressive aphasia/ exp Primary Progressive Nonfluent Aphasia/ exp frontotemporal dementia/ exp pick presenile dementia/ exp presenile dementia/ exp senile dementia/ exp multiinfarct dementia/ mental deterioration/ exp diffuse lewy body disease/ exp "mixed depression and dementia"/ (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,kw,kf and (2016* or 2017* or 2018*).em or/1-12, exp family centered care/ exp family coping/ exp family counseling/ exp caregiver support/ or/