RANKL(Receptor Activator of NFκB Ligand) RANKL CT MRI 5 RANKL. (Jones DH., Nature. 2006) RANKL RANK-Fc RANKL

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2 1970 CTMRI (Mundy G R., Nat Rev Cancer. 2002) RANKL(Receptor Activator of NFκB Ligand) RANKL RANKL (Jones DH., Nature. 2006) RANKL RANK-Fc RANKL 2 (Lamoureux F, Mol Cancer Ther. 2008, Lamoureux F, Cancer Res. 2007) RANK-Fc RANK-Fc RANKL RANK RANKL IgG Fc RANKL RANKL RANK RANK-Fc 1) RANK-Fc RANKL RANK-Fc

3 RANKL RANK-Fc 24 RANKL RANK-Fc 48 2) RANK-Fc poly-hema RANK-Fc RANKL 4872 MTT Boyden chamber scraping assay invasion assay Impact of hospital volume on postoperative complications and in-hospital mortality after musculoskeletal tumor surgery: analysis of a national administrative database. J Bone Joint Surg Am 95(18): (2013) 2Ogura K, Kawano H(3 ) Incidence and risk factors for pulmonary embolism after primary musculoskeletal tumor surgery. Clin Orthop Relat Res. 471(10): (2013) 3Ogura K, Kawano H(9 ) Neoadjuvant and adjuvant chemotherapy with modified mesna, adriamycin, ifosfamide, and decarbazine (MAID) regimen for adult high-grade non-small round cell soft tissue sarcomas. Int J Clin Oncol 18(1): (2013) 4Saita K, Kawano H. (4 3 )Chest wall deformity found in patientswith primary spontaneous pneumothorax. Asian Cardiovascular & Thoracic Annals. published online 11 July ) RANK-Fc RANKL RANK-Fc 2) RANK-Fc RANK-Fc 233 1Ogura K, Kawano H(5 ) 5Tsuda Y, Kawano H, (7 7 ) Incidence of, and risk factors for, postoperative venous thromboembolism in patients with benign or malignant musculoskeletal tumors. J Orthop Sci Jul;18(4): Yamamoto Y, Kawano H(19 8 ) Vitamin D receptor in osteoblasts is a negative regulator of bone mass control. Endocrinology Mar;154(3): Ogura K, Kawano H. (9 ) Neoadjuvant and adjuvant chemotherapy with modified mesna, adriamycin, ifosfamide, and decarbazine (MAID) regimen for adult high-grade non-small round cell soft tissue sarcomas. Int J Clin Oncol. 2013

4 Feb;18(1): Shoda N, Kadono Y(5 6 ) 8Matsumoto T, Kadono Y (8 6 ) Regulation of bone-resorption and sealing zone formation in osteoclasts occurs through Akt-mediated microtubule stabilization. J Bone Miner Res. 28(5): (2013) Risk factors affecting inhospital mortality after hip fracture: retrospective analysis using the Japanese Diagnosis Proc edure Combination Database. BMJ Open.4;2. (2012) 16Matsumoto T, Kadono Y(6 6 9Ogura K, Kawano H. (6 7 ) Alveolar soft part sarcoma: a single-center 26-patient case series and review of the )Distinguishing the pro-apoptotic and anti-resorptive functions of risedronate in osteoclasts: Role of the Akt pathway and literature. Sarcoma. 2012; 2012: the Erk/Bim axis. Arthritis Rheum 63(12): (2011) 10Ogura K, Kawano H. (5 6 )17Yasui T, Kadono Y(10 2 ) Extraskeletal myxoid chondrosarcoma: a Regulation of RANKL-induced review of 23 patients treated at a single referral center with long-term follow-up. osteoclastogenesis by TGF-β through molecular interaction between Smad3 and Arch Orthop Trauma Surg TRAF6. J Bone Miner Res 26(7): Oct;132(10): (2011) 11Ogura K, Kawano H. (7 ) 5 Bone radiofrequency ablation combined with 1Kawano H, Shinoda Y et al.: Clinical prophylactic internal fixation for metastatic bone tumor of the femur from hepatocellular outcome of surgical treatment for tumor induced osteomalacia with phosphaturic carcinoma. Int J Clin Oncol mesenchymal tumor, mixed connective Aug;17(4): tissue variant International 12Ogura K, Kawano H. (4 ) Society of Limb Salvage 17 th General Recurrent epithelioid hemangioma: Meeting(Bologna, Italy) therapeutic potential of tranilast and 2Shinoda Y, Kawano H, et al.: Prediction indomethacin. J Orthop Sci of pathologic fracture risk in stance and Mar;17(2): Ogura K, Kawano H. (3 ) Periosteal osteoblastoma of the distal femur: a case report and a review of the literature with special emphasison the MR features. Int fall loading configurations for metastases in the proximal femur, using CT-based finite element method International Society of Limb Salvage 17 th General Meeting(Bologna, Italy) Canc Conf J : Shinohara M, Kadono Y(12 5 ) Class IA phosphatidylinositol 3Tsuda Y, Kawano H, et al.: A retrospective analysis of gemcitabine and docetaxel combination on neoadjuvant and adjuvant 3-kinase regulates osteoclastic bone therapy compared with modified mesna, resorption through Akt-mediated vesicle adriamycin, ifosfamide, and dacarbazine transport. J Bone Miner for adult soft tissue non-metastatic Res.27(12): (2012) sarcomas International

5 Society of Limb Salvage 17 th Meeting(Bologna, Italy) General 4Shinoda Y, Kawano H, et al.: Fenestration of lateral cortex at proximal femur had smaller effect on fracture risk.- The analysis by CT-based finite element method th The Connective Tissue Oncology Society Annual Meeting (New York, USA) 5Tsuda Y, Kawano H, et al.: A retrospective analysis of gemcitabine and docetaxel combination on neoadjuvant and adjuvant therapy compared with modified mesna, adriamycin, ifosfamide, and dacarbazine for adult soft tissue non-metastatic sarcomas th The Connective Tissue Oncology Society Annual Meeting (New York, USA)