Psykiatriplan 2013-2016: Høringsvar fra LMU Center for Psykiatrisk Forskning. LMU takker for muligheden for at afgive høringssvar og finder anledning til at fremsætte følgende kommentarer til afsnit 11: Mere kliniknær forskning. Det anføres i psykiatriplanen: Psykiatrien i Region Midtjylland har en lang tradition for at bidrage væsentligt til den psykiatriske forskning både nationalt og internationalt. Regionen har en særlig styrke og tradition i forhold til grundforskningen, og den kliniske forskning er under udbygning Vi hilser det velkomment, at der satses på at styrke klinisk forskning. En opgørelse af phdafhandlinger og disputatser for perioden 1991-2012, der er udført eller igangværende på Center for Psykiatrisk Forskning herunder de tidligere forskningsafdelinger - eller finansieret af den nu nedlagte psykiatriske forskningspulje, viser at 43 ud af 68 afhandlinger har inddraget patienter og derfor kan betegnes som klinisk eller klinisk-translationel forskning, mens rent dyreeksperimentelle og registerstudier kun tegner sig for 25 afhandlinger (se bilag). Der foreligger derfor en væsentlig opgave ved reorganisering af forskningen i at sikre, at denne kliniske og klinisk-translationelle forskning kan videreføres på samme høje niveau som i de foregående to årtier. Vi skønner det vigtigt optimalt at udnytte den forskningsmæssige ekspertise, som en række medarbejdere har opnået gennem deres phd-grad. Ud over, som foreslået i Psykiatriplanen, at muliggøre dette ved kombinationsstillinger, vil vi også foreslå, at der gives mulighed for, at klinisk arbejdende personer kan få tidsbegrænsede frihed af varierende længde til forskning. Det bliver endeligt særdeles vigtigt, under den nye organisationsform, at sikre sammenhængende og stærke forskningsmiljøer, der kan virke tiltrækkende på fremtidige forskningsaktive personer og gøre den samlede forskning international attraktiv og kompetitiv i fondsmæssige sammenhæng. Vi skal afslutningsvist anføre, at der i udkast til psykiatriplanen skal ske justering af terminologien i relation til Center for Psykiatrisk Forskning og Core-funktionen. 29. oktober 2012 På vegne af LMU ved Center for Psykiatrisk Forskning Raben Rosenberg (formand).
Bilag Phd-afhandling og disputatser Center for Psykiatrisk Forskning og Psykiatrisk Forskningspulje 1991-2012 1 1. Henningsen, K 2. The Chronic mild stress model - Investigating behavioral and molecular aspects related to depression 2. Foldager, L. A statistical perspective on gene-environment and gene-gene interactions in association studies of schizophrenia 3. Christiansen, S. L. Chronobiology in the Chronic Mild Stress Animal Model of Depression -Involvement of molecular clock genes in the pathology and etiology of major depressive disorder 4. Nyboe, L. Metabolisk syndrom hos ny-diagnosticerede patienter med skizofreni - prognose og forebyggelse 5. Nava, N. Stress-induced glutamatergic dysfunction in a rat model of behavioral stress 6. Hartmann, T. Brain function in OCD: A fmri-study 7. Hansen, K. Omkring børn af forældre med depression. 8. Gregersen, N. Identifikation og undersøgelse af genetiske risikofaktorer for udvikling af panikangst 9. Devantier, T.A. Sammenhænge mellem depression og kardiovaskulær sygdom hos førstegangsdeprimerede over 50 år. 10. Fischer, C.W Chronic low-grade inflammation as a primer for affective disorders and metabolic syndrome in normal and genetically susceptible rats. 11. Gjerløff, T. PET-hjerneskanningsstudiee af voksne med ADHD: En dobbelt-blind randomiseret undersøgelse af behandling med hhv. atomoxetin, metylfenidat og placebo 12. Renvillard, S.G. Cognitive Function and Depression in Patients with Chronic Hepatitis-C Virus before and after Treatment 13. Hjerrild, S. Cerebral involvement in chronic hepatitis C infection assessed by MRI 1 Kliniske og klinisk/translationelle phd afhandlinger, der har undersøgt patienter, er anført med gult 2 Nr 1-15: Igangværende phd projekter 2
14. Olesen, L.Ø. The neural basis of cognitive deficits in a mouse model of dementia. 15. Austin, S. Metakognitive antagelser og psykopatologi: en undersøgelse i forbindelse med 10 års opfølgningen af OPUS-kohorten 16. Bisgaard, C. 2012. Comparative Proteomics in the Chronic Mild Stress Rat Model of Depression. 17. Severinsen, K. 2011. Ligand Binding to the Serotonin Transporter and its functional aspects. Aarhus Universitet. 18. Wegener, G. 2011. Preclinical Studies of Serotonin and Nitric Oxide in Affective Disorders (disputants). 19. Christensen, T. 2010. Gene Expression profiling study in a rat chronic mild stress model of depression. 20. Jónsson, H. 2010. Group versus individual cognitive behavioural therapy for obsessive compulsive disorder and the role of dysfunctional beliefs in treatment outcome. Department of Psychology, Aarhus Universitet. 21. Kjær, S.L. 2010. Stress during fetal life and acousitc startle response changes in adult rat offspring. Faculty of Health Sciences, Aarhus University. 22. Liebenberg, N. 2010. The inhibition of phosphodiesterase type 5 as a novel target for antidepressant action. 23. Madsen, J.A. 2010. MRI Cerebral Morphometry: Tools for the study of neuro-degenerative diseases. 24. Chen, F. 2009. Neuronal and synaptic plasticity in subregions of rat hippocampus after antidepressant treatment: Ph.D thesis [Århus], Faculty of Health Sciences, University of Aarhus. 25. Dalby, R.B. 2009. MRI-defined cerebral white matter lesions in late-onset major depression: PhD dissertation [Århus], Faculty of Health Sciences, Aarhus University. 26. Hviid, L.B. 2009. Visuospatial navigation and hippocampal function in remitted depressed patients Aahus University, Risskov, Center for Psychiatric Research. 27. Teglbjærg, H.S. 2009. Kunstterapi i psykiatrisk behandling: med særlig fokus på skizofreni Århus, Det Sundhedsvidenskabelige Fakultet, Århus Universitet. 28. Arendt, M. 2008. Comorbidity between cannabis use and psychiatric disorders: PhD thesis [Aarhus], Faculty of Health Sciences, University of Aarhus. 29. Fjorback, A.W. 2008. Regulation and trafficking of the monoamine transporters. University of Aarhus. 30. Kristensen, A.S. 2008. The structure of anxiety symptoms. An investigation of the factor structure of anxiety symptoms in panic disorder and social phobia and the relationship between symptom dimensions and personality. University of Aarhus. 3
31. Lægsgaard, M.M. 2008. Attitudes towards psychiatric genetics among future users and providers of psychiatric genetic testing and counselling: PhD thesis [Århus], Faculty of Health Sciences, University of Aarhus. 32. Bergström, A. 2007. Stress Resilience and antidepressant resistance in the chronic mild stress model of depression. 33. Bonefeld, B. 2007. Molecular Mechanisms in Treatment and Pathology of Depression : Special Focus on the Nitric Oxide system and Metabolism of Inositol Hexakisphosphate. University of Aarhus. 34. Buttenschøn, H.N. 2007. Glutamate decarboxylase 1 as a suspectibility gene for autism, bipolar affective disorder and schizophrenia. 35. Hasselstrøm, J. 2007. Metabolism and therapeutic drug monitoring of quetiapine. Faculty of Health Science, University of Aarhus. 36. Jayatissa, M.N. 2007. Pathophysiology of depression and mechanisms of antidepressant treatments; focus on neurogenesis and gene expression in a chronic mild stress animal model of depression. Faculty of Health Sciences. University of Aarhus. 37. Jacobsen, I.S. 2006. Identification of susceptibility genes for psychiatric diseases based on structural chromosome aberrations. Faculty of Health Sciences. University of Aarhus. 38. Møller, H.K. 2006. Identification and Characterisation of Serotonin Transporter Interacting Proteins. 39. Neubauer, H.A. 2006. Mapping and characterization of an allosteric mechanism on the serotonin transporter. Det sundhedsvidenskabelige Fakultet, Aarhus Universitet. 40. Østergaard Christensen, T. 2006. Kognitive og psykosociale dysfunktioner ved skizofreni Aarhus, Aarhus Universitet, Psykologisk Institut. 41. Bjerrum, M. 2005. Dansk hospitalspsykiatri 1930-1990 med særlig henblik på organisatoriske og administrative forhold Aarhus, Afdeling for Sygeplejevidenskab, Aarhus Universitet. 42. Broeng Ejsing, T. 2005. An experimental study on the pharmacokinetics of psychotropic drugs with focus on the role of the drug transporter P-glycoprotein. 43. Sinning, S. 2005. Characterisation of the ligand binding site of the human serotonin transporter. 44. Teruel, B.M. 2005. Genetic mapping and identification of genes involved in bipolar affective disorder in Cuban families. 45. Videbech, P. 2005. Towards a neurobiology of major depression: structural and functional cerebral abnormalities [S.l.], [Poul Videbech]. 46. Sørensen, M.J. 2004. Depressive symptoms in children and adolescents: a study of psychopathology. Det Sundhedsvidenskabelige fakultet. 4
47. Clausen, L. 2003. Udbytte og forandring hos spiseforstyrrede patienter i psykoterapeutisk behandling - en 2 1/2 års opf lgning. : 2 bd. Psykologisk Institut, Aarhus Universitet. 48. Valbak, K. 2003. Suitability for Psychoanalytic Psychotherapy. F llestrykkeriet for Sundhedsvidenskab, Aarhus Universitet. 49. Jensen, B.R. 2002. Cognitive function in major depression and normal subjects : The danish PET/depression project. University of Aarhus, Institute of Psychology, and Psychiatric Hospital, Institute for Basic Psychiatric Research. 50. Bennedsen, B.E. 2001. Pregnancy outcome among women with schizophrenia. Pregnancy complications, delivery complications, and infant death. Afdeling for Psykiatrisk Demografi, Psykiatrisk Hospital i Aarhus. 51. Degn, B. 2001. In search of a susceptibility gene for bipolar affective disorder on chromosome 12q24. 52. Dorph-Petersen, K.A. 2001. Neuronal changes in the dorsal raphe nucleus in depression? University of Aarhus. 53. Egedal Bennedsen, B. 2001. Pregnancy outcome among women with schizophrenia: pregnancy complications, delivery complications, and infant death: PhD thesis Aarhus, Faculty of Health Sciences, University of Aarhus. 54. Hansen, M.S. 2001. Mental Illness in Medical Inpatients. Afdeling for Psykiatrisk Demografi, Psykiatrisk Hospital i Aarhus. 55. Andersen F. Automation methods for the porcine brain. A study of the miniature Göttingen pig. 56. Sørensen, L. 2001. Psychiatric morbidity and the use of psychotropics in Danish nursing homes. Det Sundhedsvidenskabelige fakultet. 57. Day Poulsen, H. 2000. Coercion in psychiatry: the diagnostic pattern, patients' perceived coersion, and validation of the official statistics on involuntary commitments [Aarhus], Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Aarhus University Hospital. 58. Hansen, S. 2000. Substance use disorders among hospitalized patients in Denmark. 59. Wegener, 2000 G. Conventional and experimental antidepressant augmentation. 60. Ewald, H. 1997. Linkage analysis between bipolar affective disorder and autosomal candidate genes and regions [Risskov], Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, University of Aarhus. 61. Nøhr Jensen, P. 1995. Serotonin uptake in blood platelets as a peripheral marker in neuropsychiatry: method optimation and application Århus, University of Aarhus. 5
62. Tehrani, E. 1995. Kontinuitet og patienttilfredshed i psykiatrien: udvikling og afprøvning af metoder til kvalitetsvurdering af psykiatriske behandlingsforløb Risskov, Institut for psykiatrisk grundforskning, Afdeling for psykiatrisk demografi, Psykiatrisk Hospital i Århus. 63. Munk-Jørgensen, P. 1995 Faldende førstegangsindlæggelsesrater for skizofreni i Danmark 1970-91 64. Mortensen PB. 1995.The Epidemiology of Cancer in Schizophrenic Patients.University of Aarhus, 1995 (Disputats). 65. Engberg, M. 1994. Frihedsberøvelse i psykiatrien og aspekter ved den nye psykiatrilovs funktion Risskov, Institut for psykiatrisk grundforskning, Afdeling for psykiatrisk demografi, Psykiatrisk Hospital i Århus. 66. Mors, O. 1994. A descriptive epidemiological study of personality disorders among first ever admitted psychiatric patients in Denmark Risskov, Institute of Basic Psychiatric Research, Department of Psychiatric Demography, Psychiatric Hospital in Aarhus. 67. Søgaard, H.J. 1994. Distriktspsykiatri i Viborg amt, region Nord. 68. Fink, P. 1993. Psykiatrisk og somatisk comorbiditet: befolkningens forbrug af hospitalsindlæggelser Risskov, Institut for psykiatrisk grundforskning, Afdeling for psykiatrisk demokrafi, Psyk. Hospital i Århus (Disputats) Risskov 29. oktober 2012 6