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1 (1384 ) * : (6 ) (3 ). LDL HDL. :. 50mg/kg.. HDL LDL. 6/8 40/7 : LDL. HDL :. 84/6/15 : 84/6/1 : : 83/12/1 : Yahoo.com : : - *

2 9 /.(9 8). (ω3) (15) LDL (14) (14) HDL (16) LDL (ω3) (15) (17) HDL (18) LDL.(19) (ω3) HDL LDL 120. : : 50 [Upjohn Michigan (STZ)] 18..(2 1) ( ).(3-5)...(6). 3 (ω6) 6 6.(ω3) 3.(7).(6).(8) ADH TSH (ω3).(9-13).

3 1384 / 1 / (120/6 ± 5) mg/dl (424 ± 20/5) mg/dl (P<0/001). (P< 0/001).(P<0/05) HDL LDL. 1 (P<0/01). mg/dl (89/1±5) mg/dl (132/1 ±10/5).(P<0/01).(P<0/001). (62±2/7) mg/dl STZ.(9) 300mg/dl : (Menhaden, Sigma Co Germany) (Fish-Oil). 1/2ml %10.(8).. : (Cavernous Sinus) ( Kone Specific) HDL. 4 LDL. : Tukey Unpaired T-test Mean±SEM. P<0/05.

4 11 / ***c Glucose (mg/dl) ***a ***b N D D+F D+C Groups :D+F :D :N -1 N D :a :D+C D+C D :c D+F D :b *** : P<0/001 (1 HDL-C(mg/d) LDL-C(mg/dl) (mg/dl) (mg/dl) 38/2±2 36/7±1/34 40/5±4/1 39/4±3/05 65/9±6/5 71/3±7 c 89/3 ±5 b 92/6±3 a 30/1± 1/2 29/8± 0/7 66/4± 7/3 g 65/2± 8/5 131± 12/1 122/4±13/3 132/1±10/5 129/2±8/2 40± 3/46 31/9± 2/12 63/1± 12/9 57/8± 8/07 d 62± 2/7 115/7± 6/5 115/5± 7/6 113/5± 3/1 + 39/5± 2/3 35± 2/15 50± 3/06 58/9± 8/07 93± 2/7 110/7± 7/1 107/5± 8 131/1± 12/7 + P<0/001 :a P<0/01 :b P<0/005 :c P<0/01 :d P<0/005 :g P<0/01 :h

5 1384 / 1 / 12. ( ) - (22). (23). (14 21) HDL LDL (14 21) ( ) 6.(21) VLDL.(24) 6-3. HDL...(P<0/01) (93±2/7) mg/dl 1. HDL LDL mg/dl LDL (P<0/05) (65/2±8/5) HDL.(P<0/01) ). (. (20) (19) (19) ).(21) (6... LDL HDL.

6 13 /. References: : : Stepanovic V, Awad O, Jiao C, et al. Leprdb diabetic mouse bone marrow cells inhibit skin wound vascularization but promote wound healing. Circ Res 2003; 92: Anderson WAD, Thomas MS. Text book of pathology. London: Mosby Co, 1984, Jeffcoate WJ, Hading KG. Diabetic foot ulcers. Lancet 2003;361: Ruthing DJ, Meckling Gill A. Both (n-3) and (n-6) fatty acids stimulates wound healing in the rat intestinal epithelial cell line IEC-6.J. Nurt 1999;129: Luo J. Rizkalla SW, Vidal H, et al. Moderate intake of n-3 fatty acids for months has no detrimental effect on glucose metabolism and could ameliorate the lipid profile in type 2 diabetic man. Diabetes care 1998;21: : : Sweeney B, Puri P, Reen DJ. Polyunsturated fatty acids infiuence neonatal monocyte survival.pediart Surg Int 2001;17: Robertson S, Cameron NE, Cotter MA. The effect of the calcium antagonist nifedipine on peripheral nerve function in streptozotocin diabetic rats. Diabetologica 1992 ;35: Lands WEM. Biochemistry and physiology of n-3 fatty acids. FASEB J 1992;6: Thies F, Nebe-Von-Caron G, Powel JR, et al. Dietary Supplemnatation with eicosapenaenoic acid but not with other long chain n-3 or n-6 polyunsturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 years. Am J Clin Nutr 2001;73: Mori TA, Vandongen R, Masaroi JR, et al. Comparison of diets supplemented with fish oil or olive oil on plasma lipoproteine in insulin dependent diabetics. Metabolism 1991;40: Farmer A, Montori V. Fish oil in people with type2 diabetes mellitus. Cochrane Database Syst Rev 2001;3: Conner WE. Diabetes fish oil and vascular disease. Ann Inter Med 1996; 123: Petersen M, Pedersen H, Major-Pedersen A, et al. Effect of fish oil versus corn oil supplementation on LDL and HDL subclasses in type 2 diabetic patients. Diabetes care 2002; 25: Morgan WA, Raskin P, Rosentock J. A comparis of fish oil or corn oil supplements in hyperlipidemic subjects with NIDDM. Diabetes care 1995; 18: Kasim SE. Dietary marine fish oil and insulin action in zxpe2 diabetes. Ann N Y Acid Sci 1993;14: Giron MD, Sanchez F, Ortelano P, et al. Effect of dietary fatty acids on lipid metabolism in streptozotocin- induced diabetic rats. Metabolism 1999; 48: Jing L. Moderate intake of n-3 fatty acids for 2 months has detrimental effect on glucose metabolism and could ameliorate the lipid profile in type 2 diabetic men. Diabetes Care 1998; 21 : Kusunoki M, Tsutsumi K, Hara T, et al. Ethyl icosapentate (omega-3 fatty acid) causes accumulation lipids in skeletal muscle but suppress

7 1384 / 1 / 14 insulin resistance in OLETF rats. Metobolism 2003; 52: Hankenson KD, Watkins BA, Schoenlein IA, et al. Omega-3 fatty acids enhance ligament fibroblast collagen formation in association with changes in interleukin-6 production. Proc Soc Exp Biol Med 2000; 223: Ingrid T. Effect of n 3 polyunsaturated fatty acids on glucose homesostasis and blood pressure in essential hypertension. Ann Intern Med 1995; 123:

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